Effect of O6-methylguanine on the stability of G-quadruplex DNA

Mekmaysy, C; Petraccome, L; Garbett, N; Ragazzon, PA; Gray, R; Trent, J; Chaires, J

Abstract

The effects of substitution of O6-methylguanine on the structure and stability of a human telomere quadruplex was studied by circular dichroism, thermal denaturation, analytical ultracentrifugation, and molecular dynamics simulations. The results show that, while quadruplex structures can form containing the modified base, they are much less stable than the normal unmodified structure. The extent of destabilization is critically dependent on the exact position of the modified base within the quadruplex structure

Citation

Mekmaysy, C., Petraccome, L., Garbett, N., Ragazzon, P., Gray, R., Trent, J., & Chaires, J. (2008). Effect of O6-methylguanine on the stability of G-quadruplex DNA. Abstracts of papers / American Chemical Society, 130(21), 6710-6711. https://doi.org/10.1021/ja801976h

• Journal Article Type: Article
• Publication Date: Jan 5, 2008
• Deposit Date: Jan 16, 2015
• Journal: Journal of the American Chemical Society
• Print ISSN: 0002-7863
• Electronic ISSN: 1520-5126
• Peer Reviewed: Peer Reviewed
• Volume: 130
• Issue: 21
• Pages: 6710-6711
• DOI: https://doi.org/10.1021/ja801976h
• Publisher URL: http://dx.doi.org/10.1021/ja801976h
• Related Public URLs: http://pubs.acs.org/journal/jacsat/about.html
• Additional Information: Funders : National Cancel Institute (NCI); Grant Number: Grant CA35635