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The porin and the permeating antibiotic: A selective diffusion barrier in gram-negative bacteria

Pages, J; James, C; Winterhalter, M

Authors

J Pages

M Winterhalter



Abstract

Gram-negative bacteria are responsible for a large proportion of antibiotic resistant bacterial diseases. These bacteria have a complex cell envelope that comprises an outer membrane and an inner membrane that delimit the periplasm. The outer membrane contains various protein channels, called porins, which are involved in the influx of various compounds, including several classes of antibiotics. Bacterial adaptation to reduce influx through porins is an increasing problem worldwide that contributes, together with efflux systems, to the emergence and dissemination of antibiotic resistance. An exciting challenge is to decipher the genetic and molecular basis of membrane impermeability as a bacterial resistance mechanism. This Review outlines the bacterial response towards antibiotic stress on altered membrane permeability and discusses recent advances in molecular approaches that are improving our knowledge of the physico-chemical parameters that govern the translocation of antibiotics through porin channels

Citation

Pages, J., James, C., & Winterhalter, M. (2008). The porin and the permeating antibiotic: A selective diffusion barrier in gram-negative bacteria. Nature Reviews Microbiology, 6, 893-903. https://doi.org/10.1038/nrmicro1994

Journal Article Type Article
Publication Date Jan 1, 2008
Deposit Date May 31, 2013
Publicly Available Date May 31, 2013
Journal Nature Reviews in Microbiology
Print ISSN 1740-1526
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 6
Pages 893-903
DOI https://doi.org/10.1038/nrmicro1994
Publisher URL http://dx.doi.org/10.1038/nrmicro1994
Related Public URLs http://www.nature.com/nrmicro/index.html

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