The effect of antibiotic treatment on bacteriophage production by a cystic fibrosis epidemic strain of Pseudomonas aeruginosa

Fothergill, J; Mowat, E; Walshaw, M; Ledson, M; James, C; Winstanley, C

Abstract

Phage production in response to antibiotics varied among four isolates of a Pseudomonas aeruginosa
cystic fibrosis (CF) epidemic strain. Whereas ciprofloxacin induced higher levels of phage production,
other CF-relevant antibiotics led to reduced production. We detected free phages directly in CF patient
sputum samples by both plaque (40% positive) and PCR (76% positive) assays. Our observations suggest
that the choice of antibiotics could influence the number of free phages within the CF lung environment

Citation

Fothergill, J., Mowat, E., Walshaw, M., Ledson, M., James, C., & Winstanley, C. (2011). The effect of antibiotic treatment on bacteriophage production by a cystic fibrosis epidemic strain of Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy, 55(1), 426-428. https://doi.org/10.1128/AAC.01257-10

• Journal Article Type: Article
• Publication Date: Jan 1, 2011
• Deposit Date: Mar 21, 2013
• Publicly Available Date: Apr 5, 2016
• Journal: Antimicrobial Agents in Chemotherapy
• Print ISSN: 0066-4804
• Publisher: American Society for Microbiology
• Peer Reviewed: Peer Reviewed
• Volume: 55
• Issue: 1
• Pages: 426-428
• DOI: https://doi.org/10.1128/AAC.01257-10
• Publisher URL: http://dx.doi.org/10.1128/AAC.01257-10
• Related Public URLs: http://aac.asm.org/