Inflammatory bowel disease and trichuris muris

Bhardwaj, E; Else, K; Warhurst, G; Rogan, MT

Abstract

Inflammatory bowel disease (IBD) is a group of idiopathic chronic relapsing inflammatory
conditions of the gastrointestinal tract. The precise etiology of IBD is unknown,
although it is clearly multifactorial resulting from interplay of genetic, environmental
and immunological factors. Epidemiological studies show that the incidence of IBD
and other autoimmune disorders is low in the developing countries and more in the
developed countries. Evidence suggests that therapeutic administration of helminth
can reduce the symptoms of IBD in both animal models and man. However, one study
show the rat tapeworm Hymenolepis diminuta infection results in significant exacerbation
of oxazolone induced colitis in mice (Hunter et al., 2007). The mechanisms by
which helminths interact with the gut immune system in IBD-susceptible hosts, particularly
their effect on the onset and progression of colitis are poorly understood. To
address this we have investigated the interaction between Trichuris muris and the
mdr1a (-/-) mouse model, which lacks the epithelial barrier protein, p-glycoprotein and
slowly develops a spontaneous colitis in the presence of a normal gut flora.

Citation

Bhardwaj, E., Else, K., Warhurst, G., & Rogan, M. Inflammatory bowel disease and trichuris muris. Poster presented at Crohns and Colitis Foundations National Clinical and Research Conference on Advances in Inflammatory Bowel Diseases, Hollywood, Florida

• Presentation Conference Type: Poster
• Conference Name: Crohns and Colitis Foundations National Clinical and Research Conference on Advances in Inflammatory Bowel Diseases
• Conference Location: Hollywood, Florida
• End Date: Dec 7, 2008
• Publication Date: Jan 1, 2008
• Deposit Date: Dec 20, 2011
• Publicly Available Date: Apr 5, 2016
• Additional Information: Event Type : Conference