Pulmonary elimination rate of inhaled 99m Tc-sestamibi radioaerosol is delayed in healthy cigarette smokers

Ruparelia, P; Cheow, HK; Evans, JW; Banney, L; Shankar, S; Szczepura, K; Swift, AE; Ballinger, JR; Hartman, NG; Chilvers, ER; Peters, AM

Abstract

Aim - To explore inhaled technetium-99m-labelled hexakis-methoxy-isobutyl isonitrile (99mTc-sestamibi) for quantifying pulmonary P-glycoprotein(P-gp) expression.
Methods - The elimination rate from the lungs of 99mTc-sestamibi was recorded scintigraphically for 30min following inhalation as an aerosol in healthy smokers, nonsmokers and patients with lung disease.
Results - 99m Tc-sestamibi elimination rates [%min-1 (SD; P vs. healthy nonsmokers)] were: healthy nonsmokers, 0.43 (0.083); healthy smokers,0.19 (0.056; P < 0.001); chronic obstructive pulmonary disease patients, 0.26 (0.077; P < 0.001). Elimination rates in three patients with interstitial lung disease were not accelerated.
Cconclusion - Cigarette smoke upregulates lung P-gp. 99mTc-sestamibi elimination in normal smokers could be used to test new P-gp modulators. The findings also have implications for inhaled drug delivery.

• Journal Article Type: Article
• Publication Date: Apr 1, 2008
• Deposit Date: May 16, 2011
• Journal: British Journal of Clinical Pharmacology
• Print ISSN: 0306-5251
• Electronic ISSN: 1365-2125
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 65
• Issue: 4
• Pages: 611-614
• DOI: https://doi.org/10.1111/j.1365-2125.2008.03099.x
• Keywords: 99m Tc-sestamibi, aerosol, chronic obstructive pulmonary disease, lungs, P-glycoprotein, smoking
• Publisher URL: http://dx.doi.org/10.1111/j.1365-2125.2008.03099.x