Pulmonary elimination rate of inhaled 99m Tc-sestamibi radioaerosol is delayed in healthy cigarette smokers

Ruparelia, P; Cheow, HK; Evans, JW; Banney, L; Shankar, S; Szczepura, K; Swift, AE; Ballinger, JR; Hartman, NG; Chilvers, ER; Peters, AM

Abstract

Aim - To explore inhaled technetium-99m-labelled hexakis-methoxy-isobutyl isonitrile (99mTc-sestamibi) for quantifying pulmonary P-glycoprotein(P-gp) expression.
Methods - The elimination rate from the lungs of 99mTc-sestamibi was recorded scintigraphically for 30min following inhalation as an aerosol in healthy smokers, nonsmokers and patients with lung disease.
Results - 99m Tc-sestamibi elimination rates [%min-1 (SD; P vs. healthy nonsmokers)] were: healthy nonsmokers, 0.43 (0.083); healthy smokers,0.19 (0.056; P < 0.001); chronic obstructive pulmonary disease patients, 0.26 (0.077; P < 0.001). Elimination rates in three patients with interstitial lung disease were not accelerated.
Cconclusion - Cigarette smoke upregulates lung P-gp. 99mTc-sestamibi elimination in normal smokers could be used to test new P-gp modulators. The findings also have implications for inhaled drug delivery.

Citation

Ruparelia, P., Cheow, H., Evans, J., Banney, L., Shankar, S., Szczepura, K., …Peters, A. (2008). Pulmonary elimination rate of inhaled 99m Tc-sestamibi radioaerosol is delayed in healthy cigarette smokers. British Journal of Clinical Pharmacology, 65(4), 611-614. https://doi.org/10.1111/j.1365-2125.2008.03099.x

• Journal Article Type: Article
• Publication Date: Apr 1, 2008
• Deposit Date: May 16, 2011
• Journal: British Journal of Clinical Pharmacology
• Print ISSN: 0306-5251
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 65
• Issue: 4
• Pages: 611-614
• DOI: https://doi.org/10.1111/j.1365-2125.2008.03099.x
• Keywords: 99m Tc-sestamibi, aerosol, chronic obstructive pulmonary disease, lungs, P-glycoprotein, smoking
• Publisher URL: http://dx.doi.org/10.1111/j.1365-2125.2008.03099.x