Prof Geoff Hide G.Hide@salford.ac.uk
Professor
Prof Geoff Hide G.Hide@salford.ac.uk
Professor
EK Morley
JM Hughes
O Gerwash
MS Elmahaishi
KH Elmahaishi
D Thomasson
EA Wright
RH Williams
RG Murphy
JE Smith
Toxoplasma gondii is a highly ubiquitous and prevalent parasite. Despite the cat being the only definitive host, it is found in almost all geographical areas and warm blooded animals. Three routes of transmission are recognised: ingestion of oocysts shed by the cat, carnivory and congenital transmission. In natural populations, it is difficult to establish the relative importance of these routes. This paper reviews recent work in our laboratory which suggests that congenital transmission may be much more important than previously thought. Using PCR detection of the parasite, studies in sheep show that congenital transmission may occur in as many as 66% of pregnancies. Furthermore, in families of sheep on the same farm, exposed to the same sources of oocysts, significant divergent prevalences of Toxoplasma infection and abortion are found between different families. The data suggest that breeding from infected ewes increases the risk of subsequent abortion and infection in lambs. Congenital transmission rates in a natural population of mice were found to be 75%. Interestingly, congenital transmission rates in humans were measured at 19.8%. The results presented in these studies differ from those of other published studies and suggest that vertical transmission may be much more important than previously thought.
Journal Article Type | Article |
---|---|
Publication Date | Jan 1, 2009 |
Deposit Date | Oct 11, 2010 |
Publicly Available Date | Apr 5, 2016 |
Journal | Parasitology |
Print ISSN | 0031-1820 |
Electronic ISSN | 1469-8161 |
Publisher | Cambridge University Press (CUP) |
Peer Reviewed | Peer Reviewed |
Volume | 136 |
Issue | 14 |
Pages | 1877-85 |
DOI | https://doi.org/10.1017/S0031182009990941 |
Keywords | Toxoplasma gondii; vertical transmission; epidemiology; PCR; sheep; humans; mice |
Publisher URL | http://dx.doi.org/10.1017/S0031182009990941 |
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High frequency detection of Toxoplasma gondii DNA in human neonatal tissue from Libya
(2016)
Journal Article
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