Unravelling the moulting degradome: new opportunities for chemotherapy?

Craig, H; Isaac, RE; Brooks, DR

Abstract

Replacement of the nematode cuticle with a newly synthesized cuticle (a process known as moulting) occurs four times during larval development. Therefore, the key components of this essential developmental process represent attractive targets for new chemotherapeutic strategies. Recent advances in understanding the molecular genetics of nematode moulting should stimulate and facilitate development of novel drugs that target the essential molecules of the moulting cycle. In particular, we argue that further understanding of the moulting degradome and its key peptidase members offers an important opportunity for the development of novel antinematode agents.

Citation

Craig, H., Isaac, R., & Brooks, D. (2007). Unravelling the moulting degradome: new opportunities for chemotherapy?. Trends in Parasitology, 23(6), 248-253. https://doi.org/10.1016/j.pt.2007.04.003

• Journal Article Type: Article
• Publication Date: Jun 1, 2007
• Deposit Date: Sep 10, 2010
• Journal: Trends in Parasitology
• Print ISSN: 1471-4922
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 23
• Issue: 6
• Pages: 248-253
• DOI: https://doi.org/10.1016/j.pt.2007.04.003
• Publisher URL: http://dx.doi.org/10.1016/j.pt.2007.04.003
• Additional Information: Funders : Biotechnology and Biosciences Sciences Research Council (BBSRC)