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Synthesis of a simplified analogue of eleutherobin via a Claisen rearrangement and ring closing metathesis strategy

Chiang, GCH; Ayscough, A; Bond, AD; Pain, G; Ducki, S; Holmes, AB

Authors

GCH Chiang

A Ayscough

AD Bond

G Pain

S Ducki

AB Holmes



Abstract

The enantioselective synthesis of a simplified eleutherobin analogue by ring closing metathesis (RCM) of the 2,9-divinyl-substituted tetrahydro-oxonin is described; the analogue and an advanced intermediate revealed microtubule stabilising properties in the micromolar range.

Citation

Chiang, G., Ayscough, A., Bond, A., Pain, G., Ducki, S., & Holmes, A. (2005). Synthesis of a simplified analogue of eleutherobin via a Claisen rearrangement and ring closing metathesis strategy. Chemical Communications, 1860-1862. https://doi.org/10.1039/b413426e

Journal Article Type Article
Publication Date Feb 11, 2005
Deposit Date Aug 7, 2007
Journal Chemical Communications
Print ISSN 1359-7345
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Issue 14
Pages 1860-1862
DOI https://doi.org/10.1039/b413426e
Publisher URL http://dx.doi.org/10.1039/b413426e


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