GCH Chiang
Synthesis of a simplified analogue of eleutherobin via a Claisen rearrangement and ring closing metathesis strategy
Chiang, GCH; Ayscough, A; Bond, AD; Pain, G; Ducki, S; Holmes, AB
Authors
A Ayscough
AD Bond
G Pain
S Ducki
AB Holmes
Abstract
The enantioselective synthesis of a simplified eleutherobin analogue by ring closing metathesis (RCM) of the 2,9-divinyl-substituted tetrahydro-oxonin is described; the analogue and an advanced intermediate revealed microtubule stabilising properties in the micromolar range.
Citation
Chiang, G., Ayscough, A., Bond, A., Pain, G., Ducki, S., & Holmes, A. (2005). Synthesis of a simplified analogue of eleutherobin via a Claisen rearrangement and ring closing metathesis strategy. Chemical Communications, 1860-1862. https://doi.org/10.1039/b413426e
Journal Article Type | Article |
---|---|
Publication Date | Feb 11, 2005 |
Deposit Date | Aug 7, 2007 |
Journal | Chemical Communications |
Print ISSN | 1359-7345 |
Publisher | Royal Society of Chemistry |
Peer Reviewed | Peer Reviewed |
Issue | 14 |
Pages | 1860-1862 |
DOI | https://doi.org/10.1039/b413426e |
Publisher URL | http://dx.doi.org/10.1039/b413426e |
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