D Schinzer
Synthesis of furano-epothilone D
Schinzer, D; Bourguet, E; Ducki, S
Authors
E Bourguet
S Ducki
Abstract
The total synthesis of furano-epothilone D by a convergent route is reported. The key fragments are available on a large scale to provide sufficient material for biological evaluation. The approach involves a palladium-catalyzed coupling that generates a highly functionalized aldehyde which is connected in a stereoselective aldol reaction to yield the framework of furano-epothilone D. Finally, a macrolactonization provides furano-epothilone D.
Citation
Schinzer, D., Bourguet, E., & Ducki, S. (2004). Synthesis of furano-epothilone D. Chemistry - A European Journal, 10(13), 3217-3224. https://doi.org/10.1002/chem.200400125
| Journal Article Type | Article |
|---|---|
| Publication Date | Jul 5, 2004 |
| Deposit Date | Aug 7, 2007 |
| Journal | Chemistry - A European Journal |
| Print ISSN | 0947-6539 |
| Publisher | Wiley |
| Peer Reviewed | Peer Reviewed |
| Volume | 10 |
| Issue | 13 |
| Pages | 3217-3224 |
| DOI | https://doi.org/10.1002/chem.200400125 |
| Keywords | Aldol reactions, antitumor agents, epothilone analogues, macrolides, natural products |
| Publisher URL | http://dx.doi.org/10.1002/chem.200400125 |