Synthesis of furano-epothilone D

Schinzer, D; Bourguet, E; Ducki, S

Abstract

The total synthesis of furano-epothilone D by a convergent route is reported. The key fragments are available on a large scale to provide sufficient material for biological evaluation. The approach involves a palladium-catalyzed coupling that generates a highly functionalized aldehyde which is connected in a stereoselective aldol reaction to yield the framework of furano-epothilone D. Finally, a macrolactonization provides furano-epothilone D.

Citation

Schinzer, D., Bourguet, E., & Ducki, S. (2004). Synthesis of furano-epothilone D. Chemistry - A European Journal, 10(13), 3217-3224. https://doi.org/10.1002/chem.200400125

• Journal Article Type: Article
• Publication Date: Jul 5, 2004
• Deposit Date: Aug 7, 2007
• Journal: Chemistry - A European Journal
• Print ISSN: 0947-6539
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 10
• Issue: 13
• Pages: 3217-3224
• DOI: https://doi.org/10.1002/chem.200400125
• Keywords: Aldol reactions, antitumor agents, epothilone analogues, macrolides, natural products
• Publisher URL: http://dx.doi.org/10.1002/chem.200400125