Genotyping of Toxoplasma gondii isolates from cats in different geographic regions of China.

ZW, Chen; JM, Gao; XX, Huo; L, Wang; L, Yu; F, Halm-Lai; YH, Xu; WJ, Song; G, Hide; JL, Shen; ZR, Lun

Abstract

Fourteen isolates of Toxoplamsa gondii were isolated from cats from 4 different geographic provinces (Anhui, Hubei, Shanxi and Guangdong) in China and their genetic diversity with 8 nuclear loci SAG2, SAG3, BTUB, GRA6, L358, PK1, c22-8, c29-2, and an apicoplast locus Apico, was analysed by restriction fragment length polymorphisms (RFLPs). Two genotypes from these 14 isolates were identified but none of them belongs to the typical genetic types (types I, II and III). It is unexpected that such high similarity was observed in these 14 isolates although their original regions are significantly distant. Our results strongly indicate that the three traditional clonal lineages of types I, II and III of this parasite may not be preponderant in China. In addition, our results show that the genotypes of T. gondii in China may be highly clonal with atypical genotypes and higher virulence.

• Journal Article Type: Article
• Online Publication Date: Jun 24, 2011
• Publication Date: 2011-12
• Deposit Date: Apr 9, 2024
• Print ISSN: 0304-4017
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 183
• Issue: 1-2
• Pages: 166-170
• DOI: https://doi.org/10.1016/j.vetpar.2011.06.013
• PMID: 21757292