What is the relevance of FoxP3 in the tumor microenvironment and cancer outcomes?

Meyiah, Abdo; Elkord, Eyad

Abstract

Forkhead box P3 (FoxP3) transcription factor plays critical roles in controlling immune responses and cancer progression in different cancers. FoxP3 expression within the tumor microenvironment (TME) may influence clinical outcomes negatively or positively, and it could play dual roles in cancer, either by promoting or inhibiting tumor development and progression. Some studies reported that high levels of FoxP3 could be associated with tumor progression and worse prognosis, while others reported contradictory results. In this special report, we present a brief account on the role and function of FoxP3 in the TME, and its contribution to the clinical outcomes of cancer patients. Importantly, we give insights on the potential factors that could contribute to different clinical outcomes in cancer patients. Different studies showed that FoxP3 expression can be associated with bad prognoses in cancer patients. However, FoxP3 could have opposing roles by enhancing cancer progression or regression. Location and expression of FoxP3 in T cells or tumor cells can have different impacts on cancer prognoses. Different factors should be considered to establish FoxP3 as a more robust prognostic biomarker and a potential therapeutic target for enhancing anti-tumor immunity and improving clinical outcomes of cancer patients.

Citation

Meyiah, A., & Elkord, E. (in press). What is the relevance of FoxP3 in the tumor microenvironment and cancer outcomes?. Expert Review of Clinical Immunology, 1-7. https://doi.org/10.1080/1744666X.2024.2334258

• Journal Article Type: Article
• Acceptance Date: Mar 20, 2024
• Online Publication Date: Mar 25, 2024
• Deposit Date: Apr 8, 2024
• Publicly Available Date: Mar 26, 2025
• Journal: Expert review of clinical immunology
• Print ISSN: 1744-666X
• Publisher: Taylor and Francis
• Peer Reviewed: Peer Reviewed
• Pages: 1-7
• DOI: https://doi.org/10.1080/1744666X.2024.2334258
• Keywords: cancer, Tregs, FoxP3, T regulatory cells, prognosis, tumor microenvironment (TME)