Associations between prenatal alcohol exposure and early education outcomes: a matched controls study using the born in Bradford dataset

McCarthy, Robyn; A. Cook, Penny; Pink, Joshua; H. Eddy, Lucy

Abstract

Prenatal alcohol exposure (PAE) is associated with cognitive, behavioural, and developmental impairments throughout the lifespan of affected individuals, but there is limited evidence on how early this impact can be identified through routinely collected childhood data. This paper explores the relationship between PAE and the Early Years Foundation Stage Profile (EYFSP), a statutory teacher-based summative assessment of early development in relation to learning goals. This analysis uses the Born in Bradford dataset, a UK based cohort (n = 13,959; full dataset), which collected self-reported PAE from 11,905 mothers, with 19.8% reporting drinking alcohol at some point during pregnancy. Coarsened exact matching was conducted to examine relationships between patterns of PAE and children achieving a ‘Good Level of Development’ on the EYFSP, a binary variable assessed at 4–5 years of age, controlling for known confounders, including deprivation, mother’s education, exposure to other teratogenic substances, and child’s age at assessment. Additionally, we examined EYFSP sub-scores to identify specific developmental deficits associated with PAE.

The key finding is a statistically significant association between PAE at a level of consuming 5 or more units of alcohol (equivalent to 50 ml or 40 g of pure alcohol) at least once per week from the 4th month of pregnancy onwards and lower EYFSP scores when accounting for established confounding variables. These findings highlight that the detrimental impact of alcohol during pregnancy can be identified using statutory educational assessments. This has implications internationally for prevention work, policy, and commissioning of support services for people impacted by PAE.

• Journal Article Type: Article
• Acceptance Date: Oct 30, 2024
• Online Publication Date: Nov 29, 2024
• Publication Date: Nov 29, 2024
• Deposit Date: Dec 2, 2024
• Publicly Available Date: Dec 3, 2024
• Journal: Journal of Developmental Origins of Health and Disease
• Print ISSN: 2040-1744
• Electronic ISSN: 2040-1752
• Publisher: Cambridge University Press (CUP)
• Peer Reviewed: Peer Reviewed
• Volume: 15
• Article Number: e29
• DOI: https://doi.org/10.1017/S2040174424000369
• Keywords: Child, Fetal Alcohol Spectrum Disorders - epidemiology - etiology - prevention & control, school Education, Pregnancy, Child Development - drug effects, PAE, Child, Preschool, Case-Control Studies, Male, pregnancy, Alcohol Drinking - adverse effects - epidemiology, Female, Humans, Adult, Alcohol, Prenatal Exposure Delayed Effects - epidemiology, United Kingdom - epidemiology, FASD