Main genetic entities associated with tooth agenesis.

Cammarata-Scalisi, Francisco; Willoughby, Colin E; El-Feghaly, Jinia R; Tadich, Antonio Cárdenas; Castillo, Maykol Araya; Alkhatib, Shadi; Elsherif, Marwa Abd Elsalam; El-Ghandour, Rabab K; Coletta, Riccardo; Morabito, Antonino; Callea, Michele

Abstract

Tooth agenesis refers to the absence of one or more of the deciduous or permanent teeth. Tooth agenesis results from a series of disrupted reciprocal ectodermal mesenchymal interactions taking place during the early stages of tooth development. A narrative literature review was performed to describe the main genetic syndromes associated with tooth agenesis. The etiology of congenital tooth agenesis is multifactorial and include genetic, epigenetic, and environmental influences. Syndromes associated with chromosomal alterations, ectodermal dysplasia, Axenfeld-Rieger syndrome, oral-facial cleft syndromes, and syndromes with cancer predisposition are among the main entities presenting with tooth agenesis. Tooth agenesis disorders can affect the masticatory function and cause disfigurement leading to physiological and psychological complications. Early recognition of these entities is crucial to guide the management of the patient and to provide families with the appropriate genetic counseling.

• Journal Article Type: Article
• Acceptance Date: Sep 14, 2024
• Online Publication Date: Dec 11, 2024
• Publication Date: Dec 11, 2024
• Deposit Date: Jan 16, 2025
• Journal: Clinical oral investigations
• Print ISSN: 1432-6981
• Electronic ISSN: 1436-3771
• Publisher: Springer Verlag
• Peer Reviewed: Peer Reviewed
• Volume: 29
• Article Number: 9
• DOI: https://doi.org/10.1007/s00784-024-05941-7
• Keywords: Oral-facial cleft syndrome, Ectodermal Dysplasia - genetics, Ectodermal dysplasia, Anodontia - genetics, Etiology, Tooth agenesis, Chromosomal alterations, Humans