Genetic association and stress mediated down-regulation in trabecular meshwork implicates MPP7 as a novel candidate gene in primary open angle glaucoma

Vishal, M; Sharma, A; Kaurani, L; Alfano, G; Mookerjee, S; Narta, K; Agrawal, J; Bhattacharya, I; Roychoudhury, S; Ray, J; Waseem, NH; Bhattacharya, SS; Basu, A; Sen, A; Ray, K; Mukhopadhyay, A

doi:10.1186/s12920-016-0177-6

All Outputs (3)

Human brain harbors single nucleotide somatic variations in functionally relevant genes possibly mediated by oxidative stress (2016)
Journal Article
Sharma, A., Ansan, A., Kumari, R., Pandey, R., Rehman, R., Mehani, B., …Mukhopadhyay, A. (2017). Human brain harbors single nucleotide somatic variations in functionally relevant genes possibly mediated by oxidative stress. F1000Research, 5, 2520. https://doi.org/10.12688/f1000research.9495.3

Somatic variation in DNA can cause cells to deviate from the preordained genomic path in both disease and healthy conditions. Here, using exome sequencing of paired tissue samples, we show that the normal human brain harbors somatic single base va... Read More about Human brain harbors single nucleotide somatic variations in functionally relevant genes possibly mediated by oxidative stress.

TBK1 duplication is found in normal tension and not in high tension glaucoma patients of Indian origin (2016)
Journal Article
Kaurani, L., Vishal, M., Ray, J., Sen, A., Ray, K., & Mukhopadhyay, A. (2016). TBK1 duplication is found in normal tension and not in high tension glaucoma patients of Indian origin. Journal of Genetics, 95(2), 459-461. https://doi.org/10.1007/s12041-016-0637-y

Genetic association and stress mediated down-regulation in trabecular meshwork implicates MPP7 as a novel candidate gene in primary open angle glaucoma (2016)
Journal Article
Vishal, M., Sharma, A., Kaurani, L., Alfano, G., Mookerjee, S., Narta, K., …Mukhopadhyay, A. (2016). Genetic association and stress mediated down-regulation in trabecular meshwork implicates MPP7 as a novel candidate gene in primary open angle glaucoma. BMC Medical Genomics, 9(15), https://doi.org/10.1186/s12920-016-0177-6

Background: Glaucoma is the largest cause of irreversible blindness affecting more than 60 million people globally. The disease is defined as a gradual loss of peripheral vision due to death of Retinal Ganglion Cells (RGC). The RGC death is largely... Read More about Genetic association and stress mediated down-regulation in trabecular meshwork implicates MPP7 as a novel candidate gene in primary open angle glaucoma.