All Outputs (2)

Somatic CALR Mutations in myeloproliferative neoplasms with nonmutated JAK2 (2013)
Journal Article
Nangalia, J., Massie, C., Baxter, E., Nice, F., Gundem, G., Wedge, D., …Aziz, A. E. A. (2013). Somatic CALR Mutations in myeloproliferative neoplasms with nonmutated JAK2. New England Journal of Medicine, 369(25), 2391-2405. https://doi.org/10.1056/NEJMoa1312542

BACKGROUND: Somatic mutations in the Janus kinase 2 gene (JAK2) occur in many myeloproliferative neoplasms, but the molecular pathogenesis of myeloproliferative neoplasms with nonmutated JAK2 is obscure, and the diagnosis of these neoplasms remains... Read More about Somatic CALR Mutations in myeloproliferative neoplasms with nonmutated JAK2.

Cooperativity of imprinted genes inactivated by acquired chromosome 20q deletions (2013)
Journal Article
Aziz, A., Baxter, E., Edwards, C., Cheong, C., Ito, M., Bench, A., …Green, A. (2013). Cooperativity of imprinted genes inactivated by acquired chromosome 20q deletions. Journal of Clinical Investigation, 123(5), 2169-2182. https://doi.org/10.1172/JCI66113

Large regions of recurrent genomic loss are common in cancers; however, with a few well-characterized exceptions, how they contribute to tumor pathogenesis remains largely obscure. Here we identified primate-restricted imprinting of a gene cluster on... Read More about Cooperativity of imprinted genes inactivated by acquired chromosome 20q deletions.