All Outputs (4)

The Theranostic Role of Small Extracellular Vesicle Mediated microRNA in Medulloblastoma (2024)
Thesis
Amusan, O. (2024). The Theranostic Role of Small Extracellular Vesicle Mediated microRNA in Medulloblastoma. (Thesis). University of Salford

Small extracellular vesicles (sEVs) cargo can potentially alter response to chemotherapy, indicating specific cargo as a potential theranostic biomarker. In this study, we explored miRNAs mediated sEVs for chemotherapy associated biomarkers. We took... Read More about The Theranostic Role of Small Extracellular Vesicle Mediated microRNA in Medulloblastoma.

Targeting c-met in sonic hedgehog medulloblastomas (2022)
Thesis
Morlando, S. Targeting c-met in sonic hedgehog medulloblastomas. (Thesis). University of Salford

Medulloblastoma (MB), a cerebellar tumour primarily diagnosed in children, is the most common malignant brain tumour consisting of four molecular subgroups: Wingless (WNT), Sonic Hedgehog (SHH), Group 3 and Group 4. Although the 70-75% of MB patients... Read More about Targeting c-met in sonic hedgehog medulloblastomas.

Exploring potential inhibitors of the HGF-Met signalling pathway as a prospective treatment for paediatric medulloblastoma (2021)
Thesis
Hoyles, N. Exploring potential inhibitors of the HGF-Met signalling pathway as a prospective treatment for paediatric medulloblastoma. (Dissertation). University of Salford

Understanding the function of the HGF-Met signalling axis could present opportunities for new therapeutic treatments for cancer patients. The brain tumour Medulloblastoma is the leading cause of cancer-related death in children and infants meaning re... Read More about Exploring potential inhibitors of the HGF-Met signalling pathway as a prospective treatment for paediatric medulloblastoma.

Mechanisms of medulloblastoma vulnerability and new targeted therapies (2020)
Thesis
Buzzetti, M. Mechanisms of medulloblastoma vulnerability and new targeted therapies. (Thesis). University of Salford

Medulloblastoma (MB) is the most common malignant paediatric brain tumour accounting for about 20% of all childhood brain cancers. Over the last decade, a consensus has been reached over the existence of 4 main molecular subtypes, known as WNT-activa... Read More about Mechanisms of medulloblastoma vulnerability and new targeted therapies.