MYC is a major determinant of mitotic cell fate

Topham, C; Tighe, A; Ly, P; Bennett, A; Sloss, O; Nelson, L; Ridgway, RA; Huels, D; Littler, S; Schandl, C; Sun, Y; Bechi, B; Procter, DJ; Sansom, OJ; Cleveland, DW; Taylor, SS

doi:10.1016/j.ccell.2015.06.001

Taxol and other antimitotic agents are frontline chemotherapy agents but the mechanisms responsible for patient benefit remain unclear. Following a genome-wide siRNA screen, we identified the oncogenic transcription factor Myc as a taxol sensitizer.... Read More about MYC is a major determinant of mitotic cell fate.

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