All Outputs (25)

The effects of tumor necrosis factor-alpha on systolic and diastolic function in rat ventricular myocytes (2013)
Journal Article
Greensmith, D., & Nirmalan, M. (2013). The effects of tumor necrosis factor-alpha on systolic and diastolic function in rat ventricular myocytes. Physiological Reports, 1(4), e00093. https://doi.org/10.1002/phy2.93

The proinflammatory cytokine tumor necrosis factor-alpha (TNF-α) is associated with myocardial dysfunction observed in sepsis and septic shock. There are two fundamental components to this dysfunction. (1) systolic dysfunction; and (2) diastolic dysf... Read More about The effects of tumor necrosis factor-alpha on systolic and diastolic function in rat ventricular myocytes.

Diastolic spontaneous calcium release from the sarcoplasmic reticulum increases beat-to-beat variability of repolarization in canine ventricular myocytes after β-adrenergic stimulation (2013)
Journal Article
Johnson, D., Heijman, J., Bode, E., Greensmith, D., van der Linde, H., Abi-Gerges, N., …Volders, P. (2013). Diastolic spontaneous calcium release from the sarcoplasmic reticulum increases beat-to-beat variability of repolarization in canine ventricular myocytes after β-adrenergic stimulation. Circulation Research, 112(2), 246-56. https://doi.org/10.1161/CIRCRESAHA.112.275735

RATIONALE Spontaneous Ca(2+) release (SCR) from the sarcoplasmic reticulum can cause delayed afterdepolarizations and triggered activity, contributing to arrhythmogenesis during β-adrenergic stimulation. Excessive beat-to-beat variability of repol... Read More about Diastolic spontaneous calcium release from the sarcoplasmic reticulum increases beat-to-beat variability of repolarization in canine ventricular myocytes after β-adrenergic stimulation.

Age-related divergent remodeling of the cardiac extracellular matrix in heart failure: collagen accumulation in the young and loss in the aged (2012)
Journal Article
Horn, M., Graham, H., Richards, M., Clarke, J., Greensmith, D., Briston, S., …Trafford, A. (2012). Age-related divergent remodeling of the cardiac extracellular matrix in heart failure: collagen accumulation in the young and loss in the aged. Journal of Molecular and Cellular Cardiology, 53(1), 82-90. https://doi.org/10.1016/j.yjmcc.2012.03.011

The incidence of heart failure (HF) increases with age. This study sought to determine whether aging exacerbates structural and functional remodeling of the myocardium in HF. HF was induced in young (~18 months) and aged sheep (>8 years) by right ven... Read More about Age-related divergent remodeling of the cardiac extracellular matrix in heart failure: collagen accumulation in the young and loss in the aged.

Impaired β-adrenergic responsiveness accentuates dysfunctional excitation-contraction coupling in an ovine model of tachypacing-induced heart failure (2011)
Journal Article
Briston, S., Caldwell, J., Horn, M., Clarke, J., Richards, M., Greensmith, D., …Trafford, A. (2011). Impaired β-adrenergic responsiveness accentuates dysfunctional excitation-contraction coupling in an ovine model of tachypacing-induced heart failure. Journal of Physiology, 589(Pt 6), 1367-82. https://doi.org/10.1113/jphysiol.2010.203984

Reduced inotropic responsiveness is characteristic of heart failure (HF). This study determined the cellular Ca2+ homeostatic and molecular mechanisms causing the blunted β-adrenergic (β-AR) response in HF.We induced HF by tachypacing in sheep; intra... Read More about Impaired β-adrenergic responsiveness accentuates dysfunctional excitation-contraction coupling in an ovine model of tachypacing-induced heart failure.

The effects of hydrogen peroxide on intracellular calcium handling and contractility in the rat ventricular myocyte (2010)
Journal Article
Greensmith, D., Eisner, D., & Nirmalan, M. (2010). The effects of hydrogen peroxide on intracellular calcium handling and contractility in the rat ventricular myocyte. Cell Calcium, 48(6), 341-51. https://doi.org/10.1016/j.ceca.2010.10.007

Elevations in reactive oxygen species are implicated in many disease states and cause systolic and diastolic myocardial dysfunction. To understand the underlying cellular dysfunction, we characterised the effects of H₂O₂ on [Ca(2+)](i) handling and c... Read More about The effects of hydrogen peroxide on intracellular calcium handling and contractility in the rat ventricular myocyte.