All Outputs (58)

Triptolide induces pro-apoptotic effects against medulloblastoma subtypes (2025)
Presentation / Conference Contribution

Introduction
Medulloblastoma is a common cause of cancer in children, accounting for 20-25% of all paediatric brain tumours worldwide (de Medeiros et al., 2019). Whilst current treatments are effective, they are associated with substantial off-targe... Read More about Triptolide induces pro-apoptotic effects against medulloblastoma subtypes.

You don't know what you don't know; using high school outreach to improve awareness of bioscience-based careers and higher education (2025)
Journal Article

When considering the diversity of students in higher education, an important but frequently overlooked characteristic is socioeconomic background. It is well known that those from socially disadvantaged backgrounds are less likely to progress to high... Read More about You don't know what you don't know; using high school outreach to improve awareness of bioscience-based careers and higher education.

Triptonide induces pro-apoptotic effectsagainst medulloblastoma subtypes (2025)
Presentation / Conference Contribution

Introduction
Medulloblastoma is a major cause of paediatric braintumours worldwide. Whilst effective, current treatmentsare often associated with lifelong off-target effectsresulting in lower quality of life and early mortality inpaediatric patients... Read More about Triptonide induces pro-apoptotic effectsagainst medulloblastoma subtypes.

Celastrol induces pro-apoptotic and anti-migratory effects against medulloblastoma subtypes (2025)
Presentation / Conference Contribution

Introduction
Medulloblastoma accounts for 20-25% of all paediatric brain tumours diagnosed worldwide (de Medeiros et al., 2019). Current treatment regimens are effective. However, most options lead to long-term off-target effects. Therefore, the con... Read More about Celastrol induces pro-apoptotic and anti-migratory effects against medulloblastoma subtypes.

Do plasma cytokine levels correlate to cardiac function in coronary artery disease? (2024)
Presentation / Conference Contribution

Coronary artery disease (CAD) affects over 20 million people worldwide and is the leading cause of morbidity and mortality.1 In CAD, atherosclerosis narrows the coronary arteries leading to myocardial ischemia thence decreased systolic and diastolic... Read More about Do plasma cytokine levels correlate to cardiac function in coronary artery disease?.

The Role Of Interleukin-1β In Coronary Artery Disease (2024)
Thesis
Pearson, L. The Role Of Interleukin-1β In Coronary Artery Disease. (Thesis). University of Salford

Coronary artery disease (CAD) is a leading cause of mortality worldwide, with an estimated 17.8 million CAD-associated deaths each year. A prominent pathogenic factor in CAD is inflammation, which is associated with elevated levels of the cytokine in... Read More about The Role Of Interleukin-1β In Coronary Artery Disease.

Brief response to Terrar (2024)
Journal Article
Eisner, D. A., Greensmith, D. J., & Trafford, A. W. (2024). Brief response to Terrar. Journal of Physiology, https://doi.org/10.1113/JP288008

Calcium flux balance in the heart: how many of the important questions are really unanswered? (2024)
Journal Article
Eisner, D. A., Greensmith, D. J., & Trafford, A. W. (2024). Calcium flux balance in the heart: how many of the important questions are really unanswered?. Journal of Physiology, https://doi.org/10.1113/jp287849

The Journal of Physiology recently published an Opinion article which criticised our interpretation of work carried out over several years relating to calcium flux balance in cardiac myocytes (Terrar, 2024). Here,
we reply and show the importance o... Read More about Calcium flux balance in the heart: how many of the important questions are really unanswered?.

The Role of Tumour Necrosis Factor-α in Coronary Artery Disease (2024)
Thesis

Coronary artery disease (CAD) is a chronic inflammatory condition associated with high rates
of mortality worldwide. Pro-inflammatory cytokines such as tumour necrosis factor (TNFα)
play a key role in CAD pathogenesis, though the degree to which TN... Read More about The Role of Tumour Necrosis Factor-α in Coronary Artery Disease.

Calcium signaling in endothelial and vascular smooth muscle cells: sex differences and the influence of estrogens and androgens (2024)
Journal Article
Asunción-Alvarez, D., Palacios, J., Ybañez-Julca, R. O., Rodriguez-Silva, C. N., Nwokocha, C., Cifuentes, F., & Greensmith, D. J. (2024). Calcium signaling in endothelial and vascular smooth muscle cells: sex differences and the influence of estrogens and androgens. American journal of physiology. Heart and circulatory physiology, 326(4), H950-H970. https://doi.org/10.1152/ajpheart.00600.2023

Calcium signaling in vascular endothelial cells (ECs) and smooth muscle cells (VSMCs) is essential for the regulation of vascular tone. However, the changes to intracellular Ca2+ concentrations are often influenced by sex differences. Furthermore, a... Read More about Calcium signaling in endothelial and vascular smooth muscle cells: sex differences and the influence of estrogens and androgens.

Boswellia carterii oleoresin extracts induce caspase-mediated apoptosis and G 1 cell cycle arrest in human leukaemia subtypes (2023)
Journal Article
Jones, M. A., Borun, A., & Greensmith, D. J. (2023). Boswellia carterii oleoresin extracts induce caspase-mediated apoptosis and G 1 cell cycle arrest in human leukaemia subtypes. Frontiers in Pharmacology, 14, 1282239. https://doi.org/10.3389/fphar.2023.1282239

Background: Leukemias are a common cancer in adults and children. While existing treatments are effective, they are associated with severe side-effects compounded by the emergence of drug resistance. This necessitates the need to develop new drugs an... Read More about Boswellia carterii oleoresin extracts induce caspase-mediated apoptosis and G 1 cell cycle arrest in human leukaemia subtypes.

The role of interleukin-10 in coronary artery disease (2023)
Thesis

Coronary artery disease (CAD) is a leading cause of mortality and morbidity worldwide, accounting for 66,000 deaths annually in the UK. Atherosclerosis is the underlying pathophysiological mechanism which drives CAD progression, producing an inflamma... Read More about The role of interleukin-10 in coronary artery disease.

The effects of doxorubicin on calcium handling and contractility in sheep ventricular myocytes; role of oxidative stress (2023)
Presentation / Conference Contribution

Anthracyclines such as doxorubicin (DOX) are effective chemotherapeutics and contribute to improved cancer survival rates in children and adults. However, anthracyclines exhibit acute and chronic cardiotoxicity which can produce heart failure in canc... Read More about The effects of doxorubicin on calcium handling and contractility in sheep ventricular myocytes; role of oxidative stress.

The effects of anthracyclines on calcium handling and contractility in sheep ventricular myocytes; role of oxidative stress (2023)
Thesis

Anthracyclines such as doxorubicin (DOX) and daunorubicin (DAUN) are effective chemotherapeutics and contribute to improved cancer survival rates in children and adults. However, anthracyclines exhibit acute and chronic cardiotoxicity which can produ... Read More about The effects of anthracyclines on calcium handling and contractility in sheep ventricular myocytes; role of oxidative stress.

The effects of Senecio nutans hydroalcoholic extract on cardiac function (2023)
Presentation / Conference
Jones, M. (2023, May). The effects of Senecio nutans hydroalcoholic extract on cardiac function. Presented at Greater Manchester Physiology Symposium 2023, University of Salford

Enhancing employability through building graduate capital: a multi-faceted approach (2023)
Report
capital: a multi-faceted approach

The University of Salford is home to a diverse community of learners, a high proportion of whom are
from underprivileged socioeconomic backgrounds and/or underrepresented communities and many
are commuters. A significant proportion of the cohort ga... Read More about Enhancing employability through building graduate capital: a multi-faceted approach.

Characterisation of inflammatory mediators in ischaemic heart disease (2022)
Thesis
Borun, A. Characterisation of inflammatory mediators in ischaemic heart disease. (Dissertation). University of Salford

Coronary artery disease (CAD) is one of the most common causes of death in general population. In the UK it accounts for 64000 deaths annually and there are currently 2.3 million people living with CAD. Persistent inflammation of myocardium is believ... Read More about Characterisation of inflammatory mediators in ischaemic heart disease.

The role of serum biomarkers and oxidative stress in Ischemic Heart Disease (2022)
Thesis
Riley, C. The role of serum biomarkers and oxidative stress in Ischemic Heart Disease. (Dissertation). University of Salford

Ischemic heart disease also referred to as coronary artery disease (CAD) is a leading cause of death worldwide. The primary pathological mechanism underlying CAD is atherosclerosis, an inflammatory process associated with an accumulation of lipids an... Read More about The role of serum biomarkers and oxidative stress in Ischemic Heart Disease.

A hydroalcoholic extract of Senecio nutans SCh. Bip (Asteraceae); its effects on cardiac function and chemical characterization (2022)
Journal Article

Ethnopharmacology relevance
The plant Senecio nutans SCh. Bip. is used by Andean communities to treat altitude sickness. Recent evidence suggests it may produce vasodilation and negative cardiac inotropy, though the cellular mechanisms have not been... Read More about A hydroalcoholic extract of Senecio nutans SCh. Bip (Asteraceae); its effects on cardiac function and chemical characterization.

The effects of anthracyclines on calcium handling and contractility in sheep ventricular myocytes (2022)
Presentation / Conference Contribution