All Outputs (6)

Identification of constrained sequence elements across 239 primate genomes. (2023)
Journal Article
Kuderna, L. F., Ulirsch, J. C., Rashid, S., Ameen, M., Sundaram, L., Hickey, G., …Farh, K. K. (2023). Identification of constrained sequence elements across 239 primate genomes. Nature, 36, https://doi.org/10.1038/s41586-023-06798-8

Noncoding DNA is central to our understanding of human gene regulation and complex diseases , and measuring the evolutionary sequence constraint can establish the functional relevance of putative regulatory elements in the human genome . Identifying... Read More about Identification of constrained sequence elements across 239 primate genomes..

Complex Evolutionary History With Extensive Ancestral Gene Flow in an African Primate Radiation (2023)
Journal Article
Jensen, A., Swift, F., de Vries, D., Beck, R. M. D., Kuderna, L. F. K., Knauf, S., …Guschanski, K. (2023). Complex Evolutionary History With Extensive Ancestral Gene Flow in an African Primate Radiation. Molecular Biology and Evolution, 40(12), https://doi.org/10.1093/molbev/msad247

Understanding the drivers of speciation is fundamental in evolutionary biology, and recent studies highlight hybridization as an important evolutionary force. Using whole-genome sequencing data from 22 species of guenons (tribe Cercopithecini), one o... Read More about Complex Evolutionary History With Extensive Ancestral Gene Flow in an African Primate Radiation.

Complex evolutionary history with extensive ancestral gene flow in an African primate radiation (2023)
Journal Article
Jensen, A., Swift, F., de Vries, D., Beck, R., Kuderna, L. F. K., Knauf, S., …Guschanski, K. (in press). Complex evolutionary history with extensive ancestral gene flow in an African primate radiation. Molecular Biology and Evolution, 40(12), https://doi.org/10.1093/molbev/msad247

Understanding the drivers of speciation is fundamental in evolutionary biology, and recent studies highlight hybridization as an important evolutionary force. Using whole-genome sequencing data from 22 species of guenons (tribe Cercopithecini), one o... Read More about Complex evolutionary history with extensive ancestral gene flow in an African primate radiation.

The landscape of tolerated genetic variation in humans and primates. (2023)
Journal Article
Gao, H., Hamp, T., Ede, J., Schraiber, J. G., McRae, J., Singer-Berk, M., …Jolly, C. J. (2023). The landscape of tolerated genetic variation in humans and primates. Science, 380(6648), https://doi.org/10.1126/science.abn8197

Personalized genome sequencing has revealed millions of genetic differences between individuals, but our understanding of their clinical relevance remains largely incomplete. To systematically decipher the effects of human genetic variants, we obtain... Read More about The landscape of tolerated genetic variation in humans and primates..

A global catalog of whole-genome diversity from 233 primate species. (2023)
Journal Article
Kuderna, L. F. K., Gao, H., Janiak, M. C., Kuhlwilm, M., Orkin, J. D., Bataillon, T., …Jolly, C. J. (2023). A global catalog of whole-genome diversity from 233 primate species. Science, 380(6648), 906-913. https://doi.org/10.1126/science.abn7829

The rich diversity of morphology and behavior displayed across primate species provides an informative context in which to study the impact of genomic diversity on fundamental biological processes. Analysis of that diversity provides insight into lon... Read More about A global catalog of whole-genome diversity from 233 primate species..

Twenty-five well-justified fossil calibrations for primate divergences (2023)
Journal Article
de Vries, D., & Beck, R. M. D. (2023). Twenty-five well-justified fossil calibrations for primate divergences. #Journal not on list, 26(1), https://doi.org/10.26879/1249

Phylogenies with estimates of divergence times are essential for investigating many evolutionary questions. In principle, “tip-dating” is arguably the most appropriate approach, with fossil and extant taxa analysed together in a single analysis, and... Read More about Twenty-five well-justified fossil calibrations for primate divergences.