All Outputs (15)

Examining Effective Patient-Provider Communication in Antenatal Settings across England: An In-Depth Analysis of Woman’s Experiences (2024)
Working Paper
Andrzejczak, M., Jones, G. E., & Nye, G. A. Examining Effective Patient-Provider Communication in Antenatal Settings across England: An In-Depth Analysis of Woman’s Experiences

Pregnancy requires appropriate guidance and support from healthcare professionals. Understanding women’s experiences of effective patient-provider communication through antenatal care is critical, as evidence suggests, inadequate communication could... Read More about Examining Effective Patient-Provider Communication in Antenatal Settings across England: An In-Depth Analysis of Woman’s Experiences.

EVALUATING THE IMPACT OF COVID-19 ON THE PREGNANCY AND POSTNATAL PERIOD FOR UK WOMEN (2024)
Working Paper
Nye, G. A., Deb, G. A., & Dunne, S. EVALUATING THE IMPACT OF COVID-19 ON THE PREGNANCY AND POSTNATAL PERIOD FOR UK WOMEN

INTRODUCTION: Pregnancy is a crucial period which ultimately directly impacts two individuals health and wellbeing. Within the UK, a standardised pattern of care is established with collaborations across disciplines to the benefit of women and babies... Read More about EVALUATING THE IMPACT OF COVID-19 ON THE PREGNANCY AND POSTNATAL PERIOD FOR UK WOMEN.

Age‐related changes in microRNAs expression in cruciate ligaments of wild‐stock house mice (2022)
Journal Article
Kharaz, Y. A., Goljanek‐Whysall, K., Nye, G., Hurst, J. L., McArdle, A., & Comerford, E. J. (2022). Age‐related changes in microRNAs expression in cruciate ligaments of wild‐stock house mice. Physiological Reports, 10(16), https://doi.org/10.14814/phy2.15426

Cruciate ligaments (CL) of the knee joint are injured following trauma or aging. MicroRNAs (miRs) are potential therapeutic targets in musculoskeletal disorders, but there is little known about the role of miRs and their expression ligaments during a... Read More about Age‐related changes in microRNAs expression in cruciate ligaments of wild‐stock house mice.

A massively multi-scale approach to characterizing tissue architecture by synchrotron micro-CT applied to the human placenta (2021)
Journal Article

Multi-scale structural assessment of biological soft tissue is challenging but essential to gain insight into structure–function relationships of tissue/organ. Using the human placenta as an example, this study brings together sophisticated sample pr... Read More about A massively multi-scale approach to characterizing tissue architecture by synchrotron micro-CT applied to the human placenta.

Eukarion-134 Attenuates Endoplasmic Reticulum Stress-Induced Mitochondrial Dysfunction in Human Skeletal Muscle Cells (2020)
Journal Article
Thoma, A., Lyon, M., Al-Shanti, N., Nye, G. A., Cooper, R. G., & Lightfoot, A. P. (2020). Eukarion-134 Attenuates Endoplasmic Reticulum Stress-Induced Mitochondrial Dysfunction in Human Skeletal Muscle Cells. Antioxidants, 9(8), Article 710. https://doi.org/10.3390/antiox9080710

Maladaptive endoplasmic reticulum (ER) stress is associated with modified reactive oxygen species (ROS) generation and mitochondrial abnormalities; and is postulated as a potential mechanism involved in muscle weakness in myositis, an acquired autoim... Read More about Eukarion-134 Attenuates Endoplasmic Reticulum Stress-Induced Mitochondrial Dysfunction in Human Skeletal Muscle Cells.

Quantifying the impact of tissue metabolism on solute transport in feto-placental microvascular networks (2019)
Journal Article
Erlich, A., Nye, G. A., Brownbill, P., Jensen, O. E., & Chernyavsky, I. L. (2019). Quantifying the impact of tissue metabolism on solute transport in feto-placental microvascular networks. Interface Focus, 9(5), Article 20190021. https://doi.org/10.1098/rsfs.2019.0021

The primary exchange units in the human placenta are terminal villi, in which fetal capillary networks are surrounded by a thin layer of villous tissue, separating fetal from maternal blood. To understand how the complex spatial structure of villi in... Read More about Quantifying the impact of tissue metabolism on solute transport in feto-placental microvascular networks.

Placenta Imaging Workshop 2018 report: Multiscale and multimodal approaches (2018)
Presentation / Conference Contribution

The Centre for Medical Image Computing (CMIC) at University College London (UCL) hosted a two-day workshop on placenta imaging on April 12th and 13th 2018. The workshop consisted of 10 invited talks, 3 contributed talks, a poster session, a public in... Read More about Placenta Imaging Workshop 2018 report: Multiscale and multimodal approaches.

Human placental oxygenation in late gestation: experimental and theoretical approaches (2018)
Journal Article

The placenta is crucial for life. It is an ephemeral but complex organ acting as the barrier interface between maternal and fetal circulations, providing exchange of gases, nutrients, hormones, waste products and immunoglobulins. Many gaps exist in o... Read More about Human placental oxygenation in late gestation: experimental and theoretical approaches.

Comparison of Whole Body SOD1 Knockout with Muscle-Specific SOD1 Knockout Mice Reveals a Role for Nerve Redox Signaling in Regulation of Degenerative Pathways in Skeletal Muscle (2018)
Journal Article

Aims: Lack of Cu,Zn-superoxide dismutase (CuZnSOD) in homozygous knockout mice (Sod1−/−) leads to accelerated age-related muscle loss and weakness, but specific deletion of CuZnSOD in skeletal muscle (mSod1KO mice) or neurons (nSod1KO mice) resulted... Read More about Comparison of Whole Body SOD1 Knockout with Muscle-Specific SOD1 Knockout Mice Reveals a Role for Nerve Redox Signaling in Regulation of Degenerative Pathways in Skeletal Muscle.

IFPA meeting 2017 workshop report: Clinical placentology, 3D structure-based modeling of placental function, placental bed, and treating placental dysfunction (2017)
Presentation / Conference Contribution

Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialized topics. At IFPA meeting 2017 there were four themed workshops, all of which are summarized in this report. These workshops discussed new knowledge... Read More about IFPA meeting 2017 workshop report: Clinical placentology, 3D structure-based modeling of placental function, placental bed, and treating placental dysfunction.

Muscling in on mitochondrial sexual dimorphism; role of mitochondrial dimorphism in skeletal muscle health and disease (2017)
Journal Article
Nye, G., Sakellariou, G., Degens, H., & Lightfoot, A. (2017). Muscling in on mitochondrial sexual dimorphism; role of mitochondrial dimorphism in skeletal muscle health and disease. Clinical Science, 131(15), 1919-1922. https://doi.org/10.1042/cs20160940

Mitochondria are no longer solely regarded as the cellular powerhouse; instead, they are now implicated in mediating a wide-range of cellular processes, in the context of health and disease. A recent article in Clinical Science, Ventura-Clapier et al... Read More about Muscling in on mitochondrial sexual dimorphism; role of mitochondrial dimorphism in skeletal muscle health and disease.

Mitochondrial ROS regulate oxidative damage and mitophagy but not age-related muscle fiber atrophy (2016)
Journal Article

Age-related loss of skeletal muscle mass and function is a major contributor to morbidity and has a profound effect on the quality of life of older people. The potential role of age-dependent mitochondrial dysfunction and cumulative oxidative stress... Read More about Mitochondrial ROS regulate oxidative damage and mitophagy but not age-related muscle fiber atrophy.

Long‐term administration of the mitochondria‐targeted antioxidant mitoquinone mesylate fails to attenuate age‐related oxidative damage or rescue the loss of muscle mass and function associated with aging of skeletal muscle (2016)
Journal Article

Age-related skeletal muscle dysfunction is the underlying cause of morbidity that affects up to half the population aged 80 and over. Considerable evidence indicates that oxidative damage and mitochondrial dysfunction contribute to the sarcopenic phe... Read More about Long‐term administration of the mitochondria‐targeted antioxidant mitoquinone mesylate fails to attenuate age‐related oxidative damage or rescue the loss of muscle mass and function associated with aging of skeletal muscle.

SS-31 attenuates TNF-α induced cytokine release from C2C12 myotubes (2015)
Journal Article
Lightfoot, A. P., Sakellariou, G. K., Nye, G. A., McArdle, F., Jackson, M. J., Griffiths, R. D., & McArdle, A. (2015). SS-31 attenuates TNF-α induced cytokine release from C2C12 myotubes. Redox Biology, 6, 253-259. https://doi.org/10.1016/j.redox.2015.08.007

TNF-α is a key inflammatory mediator and is proposed to induce transcriptional responses via the mitochondrial generation of Reactive Oxygen Species (ROS). The aim of this study was to determine the effect of TNF-α on the production of myokines by sk... Read More about SS-31 attenuates TNF-α induced cytokine release from C2C12 myotubes.

Mechanisms of skeletal muscle ageing; avenues for therapeutic intervention (2014)
Journal Article
Lightfoot, A. P., McCormick, R., Nye, G. A., & McArdle, A. (2014). Mechanisms of skeletal muscle ageing; avenues for therapeutic intervention. Current Opinion in Pharmacology, 16, 116-121. https://doi.org/10.1016/j.coph.2014.05.005

Age-related loss of muscle mass and function, termed sarcopenia, is a catastrophic process, which impacts severely on quality of life of older people. The mechanisms underlying sarcopenia are unclear and the development of optimal therapeutic interve... Read More about Mechanisms of skeletal muscle ageing; avenues for therapeutic intervention.