All Outputs (18)

Lab Equipment Identifier: An Interactive Card Game (2024)
Other
Jones, M., Yahya, F., Abdalreza, D., Matthews, H., & Rafiq, R. (2024). Lab Equipment Identifier: An Interactive Card Game

This interactive card game is designed to introduce key laboratory equipment to students of all ages as a preparative activity for being exposed to real implements within practical sessions. This game aligns with numerous subject areas with laborator... Read More about Lab Equipment Identifier: An Interactive Card Game.

Health and Safety Hazard Hunter: A Hazard Symbol Card Game (2024)
Other
Rafiq, R., Matthews, H., Abedalreza, D., Yahya, F., & Jones, M. (2024). Health and Safety Hazard Hunter: A Hazard Symbol Card Game

This interactive card game is designed to teach students about key Health and Safety symbols that they will come across during their studies in Biomedicine, Medicine and/or Chemical Sciences. We also introduce key examples of compounds associated wit... Read More about Health and Safety Hazard Hunter: A Hazard Symbol Card Game.

PPE Lab Gear Up: A Personal Protective Equipment Puzzle Game (2024)
Other
Matthews, H., Rafiq, R., Abedalreza, D., Yahya, F., & Jones, M. (2024). PPE Lab Gear Up: A Personal Protective Equipment Puzzle Game

This interactive scenario-based puzzle game is designed to support students in learning the appropriate personal protective equipment to use within a laboratory environment, with scenarios designed to align with common areas of laboratory science. Th... Read More about PPE Lab Gear Up: A Personal Protective Equipment Puzzle Game.

Tambjamines as Fast-Acting Multistage Antimalarials (2024)
Journal Article

Well-tolerated and novel antimalarials that can combat multiple stages of the parasite life cycle are desirable but challenging to discover and develop. Herein, we report results for natural product-inspired novel tambjamine antimalarials. We show th... Read More about Tambjamines as Fast-Acting Multistage Antimalarials.

Dynamics of DNA Replication during Male Gametogenesis in the Malaria Parasite Plasmodium Falciparum (2022)
Journal Article

Malaria parasites undergo a single phase of sexual reproduction in their complex lifecycle. It involves specialised, sexually committed cells called gametocytes, which develop rapidly into mature gametes and mate upon entering the mosquito midgut. Ga... Read More about Dynamics of DNA Replication during Male Gametogenesis in the Malaria Parasite Plasmodium Falciparum.

Bulk‐up synchronization of successive larval cohorts of Anopheles gambiae and Anopheles coluzzii through temperature reduction at early larval stages: effect on emergence rate, body size and mating success (2021)
Journal Article

Background
Malaria persists as a huge medical and economic burden. Although the number of cases and death rates have reduced in recent years, novel interventions are a necessity if such gains are to be maintained. Alternative methods to target mosqu... Read More about Bulk‐up synchronization of successive larval cohorts of Anopheles gambiae and Anopheles coluzzii through temperature reduction at early larval stages: effect on emergence rate, body size and mating success.

Lead optimisation of dehydroemetine for repositioned use in malaria (2020)
Journal Article

Drug repositioning offers an effective alternative to de novo drug design to tackle the urgent need for novel anti-malarial treatments. The anti-amoebic compound, emetine dihydrochloride, has been identified as a potent in-vitro inhibitor of the mult... Read More about Lead optimisation of dehydroemetine for repositioned use in malaria.

Unexpected encounter of the parasitic kind (2019)
Journal Article

Both parasitology and stem cell research are important disciplines in their own right. Parasites are a real threat to human health causing a broad spectrum of diseases and significant annual rates morbidity and mortality globally. Stem cell research,... Read More about Unexpected encounter of the parasitic kind.

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis (2019)
Journal Article

Malaria and cryptosporidiosis, caused by apicomplexan parasites,
remain major drivers of global child mortality. New drugs for the
treatment of malaria and cryptosporidiosis, in particular, are of high
priority; however, there are few chemically v... Read More about Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.

A high throughput screen for next-generation leads targeting malaria parasite transmission (2018)
Journal Article

Spread of parasite resistance to artemisinin threatens current frontline antimalarial therapies, highlighting the need for new drugs with alternative modes of action. Since only 0.2–1% of asexual parasites differentiate into sexual, transmission-comp... Read More about A high throughput screen for next-generation leads targeting malaria parasite transmission.

Checks and balances? DNA replication and the cell cycle in Plasmodium (2018)
Journal Article

It is over 100 years since the life-cycle of the malaria parasite Plasmodium was discovered, yet its intricacies remain incompletely understood - a knowledge gap that may prove crucial for our efforts to control the disease. Phenotypic screens have p... Read More about Checks and balances? DNA replication and the cell cycle in Plasmodium.

A high-throughput in vitro translation screen towards discovery of novel antimalarial protein translation inhibitors (2018)
Preprint / Working Paper

Drugs that target protein synthesis are well-validated for use as antimicrobials, yet specific high throughput (HTP) methods to screen for those targeting malaria are lacking. Here, we have developed a cell free in vitro translation (IVT) assay for t... Read More about A high-throughput in vitro translation screen towards discovery of novel antimalarial protein translation inhibitors.

Investigating antimalarial drug interactions of emetine dihydrochloride hydrate using CalcuSyn-based interactivity calculations (2017)
Journal Article

The widespread introduction of artemisinin-based combination therapy has contributed to
recent reductions in malaria mortality. Combination therapies have a range of advantages,
including synergism, toxicity reduction, and delaying the onset of res... Read More about Investigating antimalarial drug interactions of emetine dihydrochloride hydrate using CalcuSyn-based interactivity calculations.

“Omics”-Informed drug and biomarker discovery : opportunities, challenges and future perspectives (2016)
Journal Article

The pharmaceutical industry faces unsustainable program failure despite significant increases in investment. Dwindling discovery pipelines, rapidly expanding R&D budgets and increasing regulatory control, predict significant gaps in the future drug m... Read More about “Omics”-Informed drug and biomarker discovery : opportunities, challenges and future perspectives.

Variation in apoptosis mechanisms employed by malaria parasites: the roles of inducers, dose dependence and parasite stages (2012)
Journal Article

Plasmodium berghei ookinetes exhibit an apoptotic phenotype when developing within the mosquito midgut lumen or when cultured in vitro. Markers of apoptosis increase when they are exposed to nitric oxide or reactive oxygen species but high concentrat... Read More about Variation in apoptosis mechanisms employed by malaria parasites: the roles of inducers, dose dependence and parasite stages.

Elizabethkingia anophelis sp. nov., isolated from the midgut of the mosquito Anopheles gambiae (2011)
Journal Article

The taxonomic position, growth characteristics and antibiotic resistance properties of a slightly yellow-pigmented bacterial strain, designated R26T, isolated from the midgut of the mosquito Anopheles gambiae, were studied. The isolate produced rod-s... Read More about Elizabethkingia anophelis sp. nov., isolated from the midgut of the mosquito Anopheles gambiae.

Naturally Occurring Triggers that Induce Apoptosis-Like Programmed Cell Death in Plasmodium berghei Ookinetes (2010)
Journal Article

Several protozoan parasites have been shown to undergo a form of programmed cell death that exhibits morphological features associated with metazoan apoptosis. These include the rodent malaria parasite, Plasmodium berghei. Malaria zygotes develop in... Read More about Naturally Occurring Triggers that Induce Apoptosis-Like Programmed Cell Death in Plasmodium berghei Ookinetes.

Drug repositioning as a route to anti-malarial drug discovery: preliminary investigation of the in vitro anti-malarial efficacy of emetine dihydrochloride hydrate
Journal Article

Background

Drug repurposing or repositioning refers to the usage of existing drugs in diseases other than those it was originally used for. For diseases like malaria, where there is an urgent need for active drug candidates, the strategy offers a... Read More about Drug repositioning as a route to anti-malarial drug discovery: preliminary investigation of the in vitro anti-malarial efficacy of emetine dihydrochloride hydrate.