All Outputs (2)

Asymmetric alkylation of diarylmethane derivatives. Improved results using methoxyethoxy substituent (2004)
Journal Article
Wilkinson, J., Rossington, S., Leonard, J., & Hussain, N. (2004). Asymmetric alkylation of diarylmethane derivatives. Improved results using methoxyethoxy substituent. Tetrahedron Letters, 45(28), 5481-5483. https://doi.org/10.1016/j.tetlet.2004.05.058

Alkylation of 2-methoxyethoxyphenyl phenyl methane using sec-BuLi and (−)-sparteine has been carried out in excellent yields and up to 94% ee. The best results were obtained in allylation reactions but methylation, ethylation, benzylation and trimeth... Read More about Asymmetric alkylation of diarylmethane derivatives. Improved results using methoxyethoxy substituent.

Asymmetric alkylation of diphenylmethane derivatives using (-)-sparteine (2004)
Journal Article
Wilkinson, J., Rossington, S., Leonard, J., & Hussain, N. (2004). Asymmetric alkylation of diphenylmethane derivatives using (-)-sparteine. Tetrahedron Letters, 45(6), 1191-1193. https://doi.org/10.1016/j.tetlet.2003.11.138

Alkylation of 2-oxygenated diphenylmethane derivatives using sec-butyllithium and (−)-sparteine gave enantiomeric excesses of up to 60% with allyl bromide but alkylations with methyl electrophiles were poorly selective. When compounds with a free hyd... Read More about Asymmetric alkylation of diphenylmethane derivatives using (-)-sparteine.