All Outputs (2)

A novel role for small molecule glycomimetics in the protection against lipid-induced endothelial dysfunction : Involvement of Akt/eNOS and Nrf2/ARE signaling (2016)
Journal Article
Mahmoud, A., Wilkinson, F., Jones, A., Wilkinson, J., Romero, M., Duarte, J., & Alexander, M. (2017). A novel role for small molecule glycomimetics in the protection against lipid-induced endothelial dysfunction : Involvement of Akt/eNOS and Nrf2/ARE signaling. BBA - General Subjects, 1861(1.A), 3311-3322. https://doi.org/10.1016/j.bbagen.2016.08.013

Background: Glycomimetics are a diverse array of saccharide-inspired compounds, designed to mimic the bioactive functions of glycosaminoglycans. Therefore, glycomimetics represent a unique source of novel therapies to target aberrant signaling and... Read More about A novel role for small molecule glycomimetics in the protection against lipid-induced endothelial dysfunction : Involvement of Akt/eNOS and Nrf2/ARE signaling.

Expanding the scope of the Babler-Daubin oxidation : 1,3-oxidative transposition of secondary allylic alcohols (2016)
Journal Article
Killoran, P., Rossington, S., Wilkinson, J., & Hadfield, J. (2016). Expanding the scope of the Babler-Daubin oxidation : 1,3-oxidative transposition of secondary allylic alcohols. Tetrahedron Letters, 57(35), 3954-3957. https://doi.org/10.1016/j.tetlet.2016.07.076

We report the catalytic chromium-mediated oxidation of secondary allylic alcohols to give α,β-unsaturated aldehydes with exclusive (E)-stereoselectivity. This facile procedure employs catalytic PCC (5 mol%) and periodic acid (H5IO6) as a co-oxidant.... Read More about Expanding the scope of the Babler-Daubin oxidation : 1,3-oxidative transposition of secondary allylic alcohols.