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Echinococcus granulosus cyst fluid enhances epithelial - mesenchymal transition (2018)
Journal Article
Mohammed, A., Allen, J., & Rogan, M. (2018). Echinococcus granulosus cyst fluid enhances epithelial - mesenchymal transition. Parasite Immunology, 40(6), e12533. https://doi.org/10.1111/pim.12533

Aims Cystic Echinococcosis is characterised by fluid filled hydatid cysts in the liver and lungs. The cysts are surrounded by a host fibrous layer (the pericyst) which acts to isolate the parasite from surrounding tissues. Previous studies in liver... Read More about Echinococcus granulosus cyst fluid enhances epithelial - mesenchymal transition.

Does hydatid cyst fluid from Echinococcus granulosus cysts have any effect on cells involved in fibrosis in cystic echinococcosis? (2016)
Journal Article
Mohammed, A., Allen, J., & Rogan, M. (2016). Does hydatid cyst fluid from Echinococcus granulosus cysts have any effect on cells involved in fibrosis in cystic echinococcosis?. Journal of Parasitology and Bacteriology, 7(5), https://doi.org/10.4172/2155-9597.C1.023

Cystic echinococcosis is characterized by the presence of slow growing hydatid cysts, usually in the liver or lungs. Survival of the parasite is based on an interaction of the host immune system and a range of parasite immune-evasive strategies. Fibr... Read More about Does hydatid cyst fluid from Echinococcus granulosus cysts have any effect on cells involved in fibrosis in cystic echinococcosis?.

The differential hormonal milieu of morning versus evening, may have an impact on muscle hypertrophic potential (2016)
Journal Article
Burley, S., Whittingham-Dowd, J., Allen, J., Grosset, J., & Onambele-Pearson, G. (2016). The differential hormonal milieu of morning versus evening, may have an impact on muscle hypertrophic potential. PLoS ONE, 11(9), e0161500. https://doi.org/10.1371/journal.pone.0161500

Substantial gains in muscle strength and hypertrophy are clearly associated with the routine performance of resistance training. What is less evident is the optimal timing of the resistance training stimulus to elicit these significant functional and... Read More about The differential hormonal milieu of morning versus evening, may have an impact on muscle hypertrophic potential.

PPAR <gamma> as a molecular target of EPA anti-inflammatory activity during TNF-<alpha>-impaired skeletal muscle cell differentiation (2012)
Journal Article
Magee, P., Pearson, S., Whittingham-Dowd, J., & Allen, J. (2012). PPAR as a molecular target of EPA anti-inflammatory activity during TNF--impaired skeletal muscle cell differentiation. Journal of Nutritional Biochemistry, 23(11), 1440-1448. https://doi.org/10.1016/j.jnutbio.2011.09.005

Activated skeletal muscle satellite cells facilitate muscle repair or growth through proliferation, differentiation and fusion into new or existing myotubes. Elevated levels of the proinflammatory cytokine tumor necrosis factor-α (TNF-α) impair this... Read More about PPAR <gamma> as a molecular target of EPA anti-inflammatory activity during TNF-<alpha>-impaired skeletal muscle cell differentiation.

PPARγ as a molecular target of EPA anti-inflammatory activity during TNF-α-impaired skeletal muscle cell differentiation (2012)
Journal Article
Magee, P., Pearson, S., Whittingham-Dowd, J., & Allen, J. (2012). PPARγ as a molecular target of EPA anti-inflammatory activity during TNF-α-impaired skeletal muscle cell differentiation. Journal of Nutritional Biochemistry, 23(11), 1440-1448. https://doi.org/10.1016/j.jnutbio.2011.09.005

Activated skeletal muscle satellite cells facilitate muscle repair or growth through proliferation, differentiation and fusion into new or existing myotubes. Elevated levels of the proinflammatory cytokine tumor necrosis factor-α (TNF-α) impair this... Read More about PPARγ as a molecular target of EPA anti-inflammatory activity during TNF-α-impaired skeletal muscle cell differentiation.

A role for peroxisome proliferator-activated receptors in the immunopathology of schistosomiasis? (2012)
Journal Article
Anthony, B., Allen, J., Li, Y., & McManus, D. (2012). A role for peroxisome proliferator-activated receptors in the immunopathology of schistosomiasis?. PPAR Research, 2012, 128068. https://doi.org/10.1155/2012/128068

Peroxisome proliferator-activated receptors (PPARs) have been demonstrated to have a role in immune regulation. In general, they are anti-inflammatory and promote Th2 type responses, and they are associated with the alternative activation of macropha... Read More about A role for peroxisome proliferator-activated receptors in the immunopathology of schistosomiasis?.

Schistosoma mansoni: egg-induced downregulation of hepatic stellate cell activation and fibrogenesis (2010)
Journal Article
Anthony, B., Mathieson, W., de Castro-Borges, W., & Allen, J. (2010). Schistosoma mansoni: egg-induced downregulation of hepatic stellate cell activation and fibrogenesis. Experimental Parasitology, 124(4), 409-420. https://doi.org/10.1016/j.exppara.2009.12.009

Eggs of Schistosoma mansoni trapped in human liver can lead to fibrosis. Since liver fibrosis requires activation of hepatic stellate cells (HSC) from a quiescent to a myofibroblastic phenotype, we investigated the effects of S. mansoni eggs on this... Read More about Schistosoma mansoni: egg-induced downregulation of hepatic stellate cell activation and fibrogenesis.

Hepatic stellate cells and parasite-induced liver fibrosis (2010)
Journal Article
Anthony, B., Allen, J., Li, Y., & McManus, D. (2010). Hepatic stellate cells and parasite-induced liver fibrosis. Parasites and Vectors, 3(1), 60. https://doi.org/10.1186/1756-3305-3-60

ABSTRACT: Fibrogenesis is a common feature of many diseases where there is severe insult to the liver. The hepatic stellate cell trans-differentiation into a myofibroblast has been identified as an important event in liver fibrogenesis and has been w... Read More about Hepatic stellate cells and parasite-induced liver fibrosis.

The omega-3 fatty acid, eicosapentaenoic acid (EPA), prevents the damaging effects of tumour necrosis factor (TNF)-alpha during murine skeletal muscle cell differentiation (2008)
Journal Article
Magee, P., Pearson, S., & Allen, J. (2008). The omega-3 fatty acid, eicosapentaenoic acid (EPA), prevents the damaging effects of tumour necrosis factor (TNF)-alpha during murine skeletal muscle cell differentiation. Lipids in Health and Disease, 7(1), 24. https://doi.org/10.1186/1476-511X-7-24

Background: Eicosapentaenoic acid (EPA) is a -3 polyunsaturated fatty acid with antiinflammatory and anti-cachetic properties that may have potential benefits with regards to skeletal muscle atrophy conditions where inflammation is present. It is al... Read More about The omega-3 fatty acid, eicosapentaenoic acid (EPA), prevents the damaging effects of tumour necrosis factor (TNF)-alpha during murine skeletal muscle cell differentiation.

TGF-beta 1 induces human alveolar epithelial to mesenchymal cell transition (EMT) (2005)
Journal Article
Kasai, H., Allen, J., Mason, R., Kamimura, T., & Zhang, Z. (2005). TGF-beta 1 induces human alveolar epithelial to mesenchymal cell transition (EMT). Respiratory Research, 6(56), https://doi.org/10.1186/1465-9921-6-56

Background: Fibroblastic foci are characteristic features in lung parenchyma of patients with idiopathic pulmonary fibrosis (IPF). They comprise aggregates of mesenchymal cells which underlie sites of unresolved epithelial injury and are associated w... Read More about TGF-beta 1 induces human alveolar epithelial to mesenchymal cell transition (EMT).

Growth factors in idiopathic pulmonary fibrosis: relative roles (2002)
Journal Article
Allen, J., & Spiteri, M. (2002). Growth factors in idiopathic pulmonary fibrosis: relative roles. Respiratory Research, 3(1), 13-22. https://doi.org/10.1186/rr162

Treatment of idiopathic pulmonary fibrosis patients has evolved very slowly; the fundamental approach of corticosteroids alone or in combination with other immunosuppressive agents has had little impact on long-term survival. The continued use of cor... Read More about Growth factors in idiopathic pulmonary fibrosis: relative roles.

Differential mRNA expression of insulin-like growth factor-1 splice variants in idiopathic pulmonary fibrosis and pulmonary sarcoidosis patients (2001)
Journal Article
Bloor, C., Knight, R., Kedia, R., Spiteri, M., & Allen, J. (2001). Differential mRNA expression of insulin-like growth factor-1 splice variants in idiopathic pulmonary fibrosis and pulmonary sarcoidosis patients. American Journal of Respiratory and Critical Care Medicine, 164(2), 265-272

Insulin-like growth factor-1 (IGF-1) is a highly mitogenic polypeptide detectable in human lung. Using competitive reverse transcriptase/polymerase chain reaction (RT-PCR), expression of four IGF-1 transcripts was examined in bronchoalveolar lavage c... Read More about Differential mRNA expression of insulin-like growth factor-1 splice variants in idiopathic pulmonary fibrosis and pulmonary sarcoidosis patients.