All Outputs (29)

Hook, line and infection : a guide to culturing parasites, establishing infections and assessing immune responses in the three-spined stickleback (2017)
Journal Article
Stewart, A., Jackson, J., Barber, I., Eizaguirre, C., Paterson, R., van West, P., …Cable, J. (2017). Hook, line and infection : a guide to culturing parasites, establishing infections and assessing immune responses in the three-spined stickleback. Advances in Parasitology, 98, 39-109. https://doi.org/10.1016/bs.apar.2017.07.001

The three-spined stickleback (Gasterosteus aculeatus) is a model organism with an extremely well-characterized ecology, evolutionary history, behavioural repertoire and parasitology that is coupled with published genomic data. These small temperate z... Read More about Hook, line and infection : a guide to culturing parasites, establishing infections and assessing immune responses in the three-spined stickleback.

Half the story : thermal effects on within-host infectious disease progression in a warming climate (2017)
Journal Article
Stewart, A., Hablutzel, P., Brown, M., Watson, H., Parker-Norman, S., Tober, A., …Jackson, J. (2018). Half the story : thermal effects on within-host infectious disease progression in a warming climate. Global Change Biology, 24(1), 371-386. https://doi.org/10.1111/gcb.13842

Immune defence is temperature-dependent in cold-blooded vertebrates (CBVs) and thus directly impacted by global warming. We asked whether immunity and within-host infectious disease progression are altered in CBVs under realistic climate warming in a... Read More about Half the story : thermal effects on within-host infectious disease progression in a warming climate.

An endemic hantavirus in field voles in northern England (2017)
Journal Article
Thomason, A., Begon, M., Bradley, J., Paterson, S., & Jackson, J. (2017). An endemic hantavirus in field voles in northern England. Emerging Infectious Diseases, 23(6), https://doi.org/10.3201/eid2306.161607

We report a PCR survey of hantavirus infection in the extensive field vole (Microtus agrestis) populations occurring in the Kielder Forest, northern England. A Tatenale virus-like lineage was frequently detected (~ 15% prevalence) in liver tissue. Su... Read More about An endemic hantavirus in field voles in northern England.

Changing expression of vertebrate immunity genes in an anthropogenic environment: a controlled experiment (2016)
Journal Article
experiment. BMC Evolutionary Biology, 16(175), https://doi.org/10.1186/s12862-016-0751-8

Background: The effect of anthropogenic environments on the function of the vertebrate immune system is a problem of general importance. For example, it relates to the increasing rates of immunologically-based disease in modern human populations and... Read More about Changing expression of vertebrate immunity genes in an anthropogenic environment: a controlled experiment.

Seasonal immunoregulation in a naturally occurring vertebrate (2016)
Journal Article
vertebrate. BMC Genomics, 17(369), https://doi.org/10.1186/s12864-016-2701-7

Background: Fishes show seasonal patterns of immunity, but such phenomena are imperfectly understood in vertebrates generally, even in humans and mice. As these seasonal patterns may link to infectious disease risk and individual condition, the nat... Read More about Seasonal immunoregulation in a naturally occurring vertebrate.

Immunology in wild nonmodel rodents : an ecological context for studies of health and disease (2015)
Journal Article
Jackson, J. (2015). Immunology in wild nonmodel rodents : an ecological context for studies of health and disease. Parasite Immunology, 37(5), 220-232. https://doi.org/10.1111/pim.12180

Transcriptomic methods are set to revolutionize the study of the immune system in naturally occurring nonmodel organisms. With this in mind, the present article focuses on ways in which the use of ‘nonmodel’ rodents (not the familiar laboratory spe... Read More about Immunology in wild nonmodel rodents : an ecological context for studies of health and disease.

An Immunological Marker of Tolerance to Infection in Wild Rodents (2014)
Journal Article
Jackson, J., Hall, A., Friberg, I., Ralli, C., Lowe, A., Zawadzka, M., …Begon, M. (2014). An Immunological Marker of Tolerance to Infection in Wild Rodents. PLoS Biology, https://doi.org/10.1371/journal.pbio.1001901

Hosts are likely to respond to parasitic infections by a combination of resistance (expulsion of pathogens) and tolerance(active mitigation of pathology). Of these strategies, the basis of tolerance in animal hosts is relatively poorly understood,wit... Read More about An Immunological Marker of Tolerance to Infection in Wild Rodents.

An immunological marker of tolerance to infection in wild rodents (2014)
Journal Article
Jackson, J., Hall, A., Friberg, I., Ralli, C., Lowe, A., Zawadzka, M., …Begon, M. (2014). An immunological marker of tolerance to infection in wild rodents. PLoS Biology, 12(7), e1001901. https://doi.org/10.1371/journal.pbio.1001901

Hosts are likely to respond to parasitic infections by a combination of resistance (expulsion of pathogens) and tolerance (active mitigation of pathology). Of these strategies, the basis of tolerance in animal hosts is relatively poorly understood, w... Read More about An immunological marker of tolerance to infection in wild rodents.

Host-parasite biology in the real world : the field voles of Kielder (2014)
Journal Article
Turner, A., Beldomenico, P., Bown, K., Burthe, S., Jackson, J., Lambin, X., & Begon, M. (2014). Host-parasite biology in the real world : the field voles of Kielder. Parasitology, 141(8), 997-1017. https://doi.org/10.1017/S0031182014000171

Research on the interactions between the field voles (Microtus agrestis) of Kielder Forest and their natural parasites dates back to the 1930s. These early studies were primarily concerned with understanding how parasites shape the characteristic cyc... Read More about Host-parasite biology in the real world : the field voles of Kielder.