All Outputs (25)

Assessment of the molecular basis of the proallergenic effects of cigarette smoke (2000)
Journal Article
Smyth, L., Machado, D., Upton, A., Good, S., Aufderheide, M., & Helm, B. (2000). Assessment of the molecular basis of the proallergenic effects of cigarette smoke. Environmental Science and Technology, 34(7), 1370-1374. https://doi.org/10.1021/es9909576

Epidemiological studies indicate a link between smoking and increased risk of immunoglobulin E-mediated allergies and asthma. The molecular basis underlying cigarette smoke related respiratory disorders are ill defined, but it is known that mast cell... Read More about Assessment of the molecular basis of the proallergenic effects of cigarette smoke.

Protein and cell engineering of components of the human receptor/effector system : applications for therapy and diagnosis (1998)
Journal Article

Adaptive immune responses characterised by the synthesis of antibodies of the immunoglobulin E (IgE) isotype play an important role in type I hypersensitivity disorders and parasitic infestations, diseases which have an significant socio-economic imp... Read More about Protein and cell engineering of components of the human receptor/effector system : applications for therapy and diagnosis.

Fcgamma RIIa polymorphism in systemic lupus erythematosus (1997)
Journal Article
Smyth, L., Snowden, N., Carthy, D., Papasteriades, C., Hajeer, A., & Ollier, W. (1997). Fcgamma RIIa polymorphism in systemic lupus erythematosus. Annals of the Rheumatic Diseases, 56(12), 744-746. https://doi.org/10.1136/ard.56.12.744

OBJECTIVES Polymorphism of the phagocyte IgG receptor FcγRIIa may modulate immune complex mediated inflammation, particularly when immune complexes contain IgG2. Previous studies suggest that this polymorphism may be an important risk factor for lupu... Read More about Fcgamma RIIa polymorphism in systemic lupus erythematosus.

Validation of shellfish isolates (glycosaminoglycans, GAGs) for development as a novel anti-tumour therapy for children : GAG action on lymphocytes/T-regulatory cells
Thesis
Jones, C. Validation of shellfish isolates (glycosaminoglycans, GAGs) for development as a novel anti-tumour therapy for children : GAG action on lymphocytes/T-regulatory cells. (Thesis). University of Salford

Introduction: Leukaemia is cancer of white blood cells (WBCs) mainly affecting children. Defective WBCs are prominent in blood and cannot provide immune protection. Although chemotherapy treatments are effective, they have many adverse effects which... Read More about Validation of shellfish isolates (glycosaminoglycans, GAGs) for development as a novel anti-tumour therapy for children : GAG action on lymphocytes/T-regulatory cells.

Molecular pathways controlling DNA damage response
Thesis
Alhebshi, H. (in press). Molecular pathways controlling DNA damage response. (Thesis). University of Salford

P53 is inactivated in around 50 % of human neoplasms and more than 26,000 somatic mutations of the p53 have reported in human cancers. P53 network is activated after cells are exposed to the DNA damage and depending on diverse conditions and type of... Read More about Molecular pathways controlling DNA damage response.