All Outputs (4)

β3-adrenoceptor stimulation of perivascular adipocytes leads to increased fat cell-derived nitric oxide and vascular relaxation in small arteries (2018)
Journal Article
Bussey, C., Withers, S., Saxton, S., Bodagh, N., Aldous, R., & Heagerty, A. (2018). β3-adrenoceptor stimulation of perivascular adipocytes leads to increased fat cell-derived nitric oxide and vascular relaxation in small arteries. British Journal of Pharmacology, 175(18), 2685-3698. https://doi.org/10.1111/bph.14433

BACKGROUND AND PURPOSE In response to norepinephrine healthy perivascular adipose tissue (PVAT) exerts an anticontractile effect on adjacent small arterial tissue. Organ bath solution transfer experiments have demonstrated the release of PVAT-deriv... Read More about β3-adrenoceptor stimulation of perivascular adipocytes leads to increased fat cell-derived nitric oxide and vascular relaxation in small arteries.

Modulation of vascular reactivity by perivascular adipose tissue (PVAT) (2018)
Journal Article
Agabiti Rosei, C., Paini, A., De Ciuceis, C., Withers, S., Greenstein, A., Heagerty, A., & Rizzoni, D. (2018). Modulation of vascular reactivity by perivascular adipose tissue (PVAT). Current Hypertension Reports, 20(44), https://doi.org/10.1007/s11906-018-0835-5

Purpose of Review: In this review we discuss the role of perivascular adipose tissue (PVAT) in the modulation of vascular contractility and arterial pressure, focusing on the role of the renin-angiotensin-aldosterone system and oxidative stress/infla... Read More about Modulation of vascular reactivity by perivascular adipose tissue (PVAT).

Personalizing hypertension treatment? (2018)
Journal Article
Withers, S., Saxton, S., & Heagerty, A. (2018). Personalizing hypertension treatment?. Hypertension, 71(6), 1028-1029. https://doi.org/10.1161/HYPERTENSIONAHA.118.11107

Editorial.

Role of sympathetic nerves and adipocyte catecholamine uptake in the vasorelaxant function of perivascular adipose tissue. (2018)
Journal Article
Saxton, S., Ryding, K., Aldous, R., Withers, S., Ohanian, J., & Heagerty, A. (2018). Role of sympathetic nerves and adipocyte catecholamine uptake in the vasorelaxant function of perivascular adipose tissue. Arteriosclerosis, Thrombosis, and Vascular Biology, 38(4), 880-891. https://doi.org/10.1161/ATVBAHA.118.310777

Objective: Healthy perivascular adipose tissue (PVAT) exerts an anticontractile effect on resistance arteries which is vital in regulating arterial tone. Activation of β3 -adrenoceptors by sympathetic nerve-derived NA (noradrenaline) may be implicate... Read More about Role of sympathetic nerves and adipocyte catecholamine uptake in the vasorelaxant function of perivascular adipose tissue..