All Outputs (4)

Interleukin-33 rescues perivascular adipose tissue anticontractile function in obesity (2020)
Journal Article
Saxton, S., Whitley, A., Potter, R., Withers, S., Grencis, R., & Heagerty, A. (2020). Interleukin-33 rescues perivascular adipose tissue anticontractile function in obesity. American journal of physiology. Heart and circulatory physiology, 319(6), H1387-H1397. https://doi.org/10.1152/ajpheart.00491.2020

Perivascular adipose tissue (PVAT) depots are metabolically active and play a major vasodilator role in healthy lean individuals. In obesity, they become inflamed and eosinophil-depleted and the anticontractile function is lost with the development o... Read More about Interleukin-33 rescues perivascular adipose tissue anticontractile function in obesity.

Perivascular adipose tissue - an immune cell metropolis (2020)
Journal Article
Saxton, S., Heagerty, A., & Withers, S. (2020). Perivascular adipose tissue - an immune cell metropolis. Experimental Physiology, 105(9), 1440-1443. https://doi.org/10.1113/EP087872

What is the topic of this review? The review discusses how eosinophils can contribute to the function of perivascular adipose tissue and explores the mechanisms involved. What advances does it highlight? Understanding the communication between the ce... Read More about Perivascular adipose tissue - an immune cell metropolis.

MiRNAs as novel adipokines : obesity-related circulating MiRNAs influence chemosensitivity in cancer patients (2020)
Journal Article
Withers, S., Dewhurst, T., Hammond, C., & Topham, C. (2020). MiRNAs as novel adipokines : obesity-related circulating MiRNAs influence chemosensitivity in cancer patients. Non-Coding RNA, 6(1), e5. https://doi.org/10.3390/ncrna6010005

Adipose tissue is an endocrine organ, capable of regulating distant physiological processes in other tissues via the release of adipokines into the bloodstream. Recently, circulating adipose-derived microRNAs (miRNAs) have been proposed as a novel cl... Read More about MiRNAs as novel adipokines : obesity-related circulating MiRNAs influence chemosensitivity in cancer patients.

Mechanisms of medulloblastoma vulnerability and new targeted therapies (2020)
Thesis
Buzzetti, M. Mechanisms of medulloblastoma vulnerability and new targeted therapies. (Thesis). University of Salford

Medulloblastoma (MB) is the most common malignant paediatric brain tumour accounting for about 20% of all childhood brain cancers. Over the last decade, a consensus has been reached over the existence of 4 main molecular subtypes, known as WNT-activa... Read More about Mechanisms of medulloblastoma vulnerability and new targeted therapies.