All Outputs (3)

Synthesis and evaluation of novel kinase inhibitors as anti-cancer agents (2012)
Thesis

Disruption of protein kinase signalling pathways is often associated with cancer. The
RhoA/ROCK kinase pathway has been shown to be constitutively expressed in many cancers
and has also been shown to be involved in metastasis and apoptosis. ROCK is... Read More about Synthesis and evaluation of novel kinase inhibitors as anti-cancer agents.

Mechanistic studies on aziridinylbenzoquinones and CCNU [l-(2-chloroethyl)- 3-cyclohexyl-l-nitrosourea] in cultured tumour cells (2007)
Thesis

This work is concerned with the action of two different anticancer drugs which can
alkylate DNA in tumour cells.
The first alkylating agent studied was CCNU [(l-(2-chloroethyl)-3-cyclohexyl-lnitrosourea,
Lomustine]. This is a well established clin... Read More about Mechanistic studies on aziridinylbenzoquinones and CCNU [l-(2-chloroethyl)- 3-cyclohexyl-l-nitrosourea] in cultured tumour cells.

Anti-tumour properties of novel diaziridinylquinones (2001)
Thesis
Di Francesco, A. Anti-tumour properties of novel diaziridinylquinones. (Thesis). Salford : University of Salford

This work is concerned with the synthesis and potential anti-tumour properties of novel
Diaziridinylquinones. These types of compounds are usually activated by bioreduction
to form cytotoxic species, which alkylate DNA and block cells in the G 2 /M... Read More about Anti-tumour properties of novel diaziridinylquinones.