All Outputs (4)

Analysis of the Role of Immune System and Microenvironment in Leukaemia (2025)
Thesis

The immune system and microenvironment have been implicated in chemotherapy resistance
in acute lymphoblastic leukaemia (ALL). Despite the development of different therapies, the
detailed mechanism underlying chemotherapy resistance is not well und... Read More about Analysis of the Role of Immune System and Microenvironment in Leukaemia.

Investigation of P53 and TTC5 function in lung cancer (2024)
Thesis

Lung cancer represents 11.6% of the total cases with patients destined for a poor outcome due to late-stage detection, therefore it is important to find new approaches to detect and treat this disease. Current evidence suggests a role of p53 gene and... Read More about Investigation of P53 and TTC5 function in lung cancer.

Targeting Transcriptional CDKs in Medulloblastoma (2024)
Thesis

Medulloblastoma (MB) is the most common malignant tumour of the brain in children. Current treatments include surgery, radiotherapy and chemotherapy. Although the five-year survival rate is over 70%, the treatment is exceptionally aggressive, leaving... Read More about Targeting Transcriptional CDKs in Medulloblastoma.

Evaluation of Novel Diketones as Anti-cancer Agents (2024)
Thesis

Recent studies indicated high levels of cytotoxicity of dibenzoylmethane (DBM) and its derivatives on some mammalian cancer cells. On the other hand, p53 tumour suppressor is a DNA damage inducible transcription factor mutated in over half of human c... Read More about Evaluation of Novel Diketones as Anti-cancer Agents.