Synthesis and evaluation of double bond substituted combretastatins
(2005)
Journal Article
Hadfield, J., Gaukroger, K., Hirst, N., Weston, A., Lawrence, N., & McGown, A. (2005). Synthesis and evaluation of double bond substituted combretastatins. European Journal of Medicinal Chemistry, 40(6), 529-541. https://doi.org/10.1016/j.ejmech.2004.12.008
A series of combretastatins substituted with epoxides, amides and small alkyl groups has been synthesised and evaluated for cytotoxicity and their ability to inhibit the assembly of tubulin. The methyl and ethyl substituted phenols 36, 44 have shown... Read More about Synthesis and evaluation of double bond substituted combretastatins.