All Outputs (5)

A candidate tolerance gene identified in a natural population of field voles (Microtus agrestis) (2017)
Journal Article
Wanelik, K., Begon, M., Birtles, R., Bradley, J., Friberg, I., Jackson, J., …Paterson, S. (2017). A candidate tolerance gene identified in a natural population of field voles (Microtus agrestis). Molecular Ecology, 27(4), 1044-1052. https://doi.org/10.1111/mec.14476

The animal immune response has hitherto been viewed primarily in the context of resistance only. However, individuals, can also employ a tolerance strategy to maintain good health in the face of on-going infection. To shed light on the genetic and ph... Read More about A candidate tolerance gene identified in a natural population of field voles (Microtus agrestis).

From the animal house to the field : are there consistent individual differences in immunological profile in wild populations of field voles (Microtus agrestis)? (2017)
Journal Article
Arriero, E., Wanelik, K., Birtles, R., Bradley, J., Jackson, J., Paterson, S., & Begon, M. (2017). From the animal house to the field : are there consistent individual differences in immunological profile in wild populations of field voles (Microtus agrestis)?. PLoS ONE, 12(8), e0183450. https://doi.org/10.1371/journal.pone.0183450

Inbred mouse strains, living in simple laboratory environments far removed from nature, have been shown to vary consistently in their immune response. However, wildlife populations are typically outbreeding and face a multiplicity of challenges, para... Read More about From the animal house to the field : are there consistent individual differences in immunological profile in wild populations of field voles (Microtus agrestis)?.

Hook, line and infection : a guide to culturing parasites, establishing infections and assessing immune responses in the three-spined stickleback (2017)
Journal Article
Stewart, A., Jackson, J., Barber, I., Eizaguirre, C., Paterson, R., van West, P., …Cable, J. (2017). Hook, line and infection : a guide to culturing parasites, establishing infections and assessing immune responses in the three-spined stickleback. Advances in Parasitology, 98, 39-109. https://doi.org/10.1016/bs.apar.2017.07.001

The three-spined stickleback (Gasterosteus aculeatus) is a model organism with an extremely well-characterized ecology, evolutionary history, behavioural repertoire and parasitology that is coupled with published genomic data. These small temperate z... Read More about Hook, line and infection : a guide to culturing parasites, establishing infections and assessing immune responses in the three-spined stickleback.

Half the story : thermal effects on within-host infectious disease progression in a warming climate (2017)
Journal Article
Stewart, A., Hablutzel, P., Brown, M., Watson, H., Parker-Norman, S., Tober, A., …Jackson, J. (2018). Half the story : thermal effects on within-host infectious disease progression in a warming climate. Global Change Biology, 24(1), 371-386. https://doi.org/10.1111/gcb.13842

Immune defence is temperature-dependent in cold-blooded vertebrates (CBVs) and thus directly impacted by global warming. We asked whether immunity and within-host infectious disease progression are altered in CBVs under realistic climate warming in a... Read More about Half the story : thermal effects on within-host infectious disease progression in a warming climate.

An endemic hantavirus in field voles in northern England (2017)
Journal Article
Thomason, A., Begon, M., Bradley, J., Paterson, S., & Jackson, J. (2017). An endemic hantavirus in field voles in northern England. Emerging Infectious Diseases, 23(6), https://doi.org/10.3201/eid2306.161607

We report a PCR survey of hantavirus infection in the extensive field vole (Microtus agrestis) populations occurring in the Kielder Forest, northern England. A Tatenale virus-like lineage was frequently detected (~ 15% prevalence) in liver tissue. Su... Read More about An endemic hantavirus in field voles in northern England.