All Outputs (1436)

Exploring potential inhibitors of the HGF-Met signalling pathway as a prospective treatment for paediatric medulloblastoma (2021)
Thesis
Hoyles, N. Exploring potential inhibitors of the HGF-Met signalling pathway as a prospective treatment for paediatric medulloblastoma. (Dissertation). University of Salford

Understanding the function of the HGF-Met signalling axis could present opportunities for new therapeutic treatments for cancer patients. The brain tumour Medulloblastoma is the leading cause of cancer-related death in children and infants meaning re... Read More about Exploring potential inhibitors of the HGF-Met signalling pathway as a prospective treatment for paediatric medulloblastoma.

High-temperature corrosion protection of gas turbine blades with micro-coatings and nano-coatings : simulation and experiments (2021)
Thesis
Kadir, A. (2021). High-temperature corrosion protection of gas turbine blades with micro-coatings and nano-coatings : simulation and experiments. (Thesis). University of Salford

Material degradation at high temperature is a serious problem in gas turbines in aircraft. In these systems, the expansion blades experience high temperatures ranging from 850 Celsius to in excess of 1000 Celsius. High temperature corrosion is very s... Read More about High-temperature corrosion protection of gas turbine blades with micro-coatings and nano-coatings : simulation and experiments.

Developing an assessment framework to enhance community resilience to pluvial floods in the UAE (2021)
Thesis
Al nuaimi, M. (2021). Developing an assessment framework to enhance community resilience to pluvial floods in the UAE. (Thesis). University of Salford

Over the last two decades, the increase in natural disasters has affected communities around the world through significant loss of life and negative environmental and economic impacts. Although communities cannot always prevent these disasters, they... Read More about Developing an assessment framework to enhance community resilience to pluvial floods in the UAE.

Developing a contextualised framework for culture-led urban sustainable development through creative hub concept (a case study of Iranian free zone) (2021)
Thesis
(a case study of Iranian free zone). (Thesis). University of Salford

Regenerating cities and adapting them to contemporary life circumstances is essential for improving cities' economic, social, and cultural situations. In order to regenerate cities, we, therefore, need to pay more attention to the cultural aspects of... Read More about Developing a contextualised framework for culture-led urban sustainable development through creative hub concept (a case study of Iranian free zone).

Synthesis and Evaluation of Benzoyl containing compounds as potential anti-cancer agents (2021)
Thesis
Ahmed, S. M. Synthesis and Evaluation of Benzoyl containing compounds as potential anti-cancer agents. (Thesis). University of Salford

Seen as one of the major causes of death worldwide, Cancer requires the development of effective treatments to combat the disease. However, pharmaceutical companies are faced by the challenge of finding and developing a suitable compound that can ove... Read More about Synthesis and Evaluation of Benzoyl containing compounds as potential anti-cancer agents.

Exploring the influence of adipokines on neuronal function in Alzheimer’s disease (2021)
Thesis
Tomar, N. Exploring the influence of adipokines on neuronal function in Alzheimer’s disease. (Thesis). University of Salford

Alzheimer’s disease (AD) is one of the major causes of dementia. Alzheimer’s disease is an irreversible, slow neurodegenerative disease leading to memory and language impairment and amyloid-β plaques and intraneuronal neurofibrillary tangles are the... Read More about Exploring the influence of adipokines on neuronal function in Alzheimer’s disease.

Establishing a structure-activity-relationship for small molecule non-sugar glycomimetics (2021)
Thesis
Dobiecki-Davies, J. Establishing a structure-activity-relationship for small molecule non-sugar glycomimetics. (Dissertation). University of Salford

DAOY Medullablastoma cells are highly invasive, mobile and can cause severe neurological and physical illness in patients affected by this cancer. Previous work by Wilkinson & Co-workers (2017) showed that some small-molecule non-sugar glycomimetic d... Read More about Establishing a structure-activity-relationship for small molecule non-sugar glycomimetics.

Numerical study of nanofluid-based direct absorber solar collector systems with metallic/carbon nanoparticles, multiple geometries and multi-mode heat transfer (2021)
Thesis
Kuharat, S. Numerical study of nanofluid-based direct absorber solar collector systems with metallic/carbon nanoparticles, multiple geometries and multi-mode heat transfer. (Thesis). University of Salford

Nanofluids are complex colloidal suspensions comprising nanoparticles (metallic or carbon based or both) suspended in a base fluid (e.g. water). The resulting suspension provides demonstrably greater thermal performance than base fluids on their own... Read More about Numerical study of nanofluid-based direct absorber solar collector systems with metallic/carbon nanoparticles, multiple geometries and multi-mode heat transfer.

Developing a strategic framework to enhance readiness of UAE law enforcement agencies to effectively respond to road traffic emergencies (2021)
Thesis
Alzaabi, E. Developing a strategic framework to enhance readiness of UAE law enforcement agencies to effectively respond to road traffic emergencies. (Thesis). University of Salford

The high number of road traffic accidents and increasing prevalence of road traffic crises around the world has brought to the fore the need for a higher level of crisis preparedness and response. In the UAE, crisis response times are significantly b... Read More about Developing a strategic framework to enhance readiness of UAE law enforcement agencies to effectively respond to road traffic emergencies.

Application of the Round-Trip theory to electro-dynamic sources of vibration (2021)
Thesis
Evans, J. Application of the Round-Trip theory to electro-dynamic sources of vibration. (Dissertation). University of Salford

The Round-Trip Identity, developed by Moorhouse & Elliott at The University of Salford allows the reconstruction of mechanical frequency response functions at remote locations on a test structure, without the need to physically measure at that locati... Read More about Application of the Round-Trip theory to electro-dynamic sources of vibration.

Proinflammatory cytokines as mediators of phenotypic change in bacteria implicated in ventilator-associated pneumonia (2021)
Thesis
Tompsett, A. Proinflammatory cytokines as mediators of phenotypic change in bacteria implicated in ventilator-associated pneumonia. (Thesis). University of Salford

Ventilator-associated pneumonia (VAP) is a common hospital-acquired infection in intensive care. VAP is associated with increased hospital stay, healthcare costs, and high mortality. VAP is difficult to diagnose and manage appropriately, leading to w... Read More about Proinflammatory cytokines as mediators of phenotypic change in bacteria implicated in ventilator-associated pneumonia.

An investigation into Toxoplasma gondii infection and the expression of Arginase-1 and iNOS in human lung tissue (2021)
Thesis
Soothill, H. An investigation into Toxoplasma gondii infection and the expression of Arginase-1 and iNOS in human lung tissue. (Dissertation). University of Salford

This study aimed to investigate the relationship between Toxoplasma gondii infection and the expression of the immune modulating proteins Arginase-1 and iNOS in human lung biopsy samples. Previously, a 100% toxoplasmosis infection rate was found in 7... Read More about An investigation into Toxoplasma gondii infection and the expression of Arginase-1 and iNOS in human lung tissue.

A study of the polarimetric characteristics of planar chiral mesoscopic structures (2021)
Thesis
Alzahrani, H. (2021). A study of the polarimetric characteristics of planar chiral mesoscopic structures. (Thesis). University of Salford

It has been shown previously that chiral materials can rotate the direction of incident polarized light. This work focuses on a new way of investigating the polarized response of chiral metamaterial structures and nanoparticles. In the theoretical pa... Read More about A study of the polarimetric characteristics of planar chiral mesoscopic structures.

Establishing a protocol to measure tetrodotoxin (TTX) levels in small bodied newts (genus Lissotriton) in western Europe (2021)
Thesis
Wagstaff, R. Establishing a protocol to measure tetrodotoxin (TTX) levels in small bodied newts (genus Lissotriton) in western Europe. (Dissertation). University of Salford

Tetrodotoxin (TTX) is a defence toxin most commonly found in marine organisms, and amphibians are the only land vertebrates (tetrapods) which are known to produce TTX. However, the origin of TTX in amphibians remains largely unknown, and our knowledg... Read More about Establishing a protocol to measure tetrodotoxin (TTX) levels in small bodied newts (genus Lissotriton) in western Europe.

Semi-active control for independently rotating wheelset in railway vehicles with MR dampers (2021)
Thesis
Zaeim, A. Semi-active control for independently rotating wheelset in railway vehicles with MR dampers. (Thesis). University of Salford

This thesis presents details of an investigation of a controller for MR damper in the implementation of semi-active control, for primary suspensions of the independently rotating railway vehicles. This research focuses on using MR damper and it add... Read More about Semi-active control for independently rotating wheelset in railway vehicles with MR dampers.

Investigating Interleukin – 8 and TGF Beta as early biomarkers predicting poor clinical outcome in major trauma (2021)
Thesis
Abbood, L. Investigating Interleukin – 8 and TGF Beta as early biomarkers predicting poor clinical outcome in major trauma. (Dissertation). University of Salford

Trauma is a leading cause of death and disability. Globally, traumatic injury is the main cause of death under the age of 45. Recent studies from the UK report a demographic change in major trauma. The most common mechanism of traumatic injury is fal... Read More about Investigating Interleukin – 8 and TGF Beta as early biomarkers predicting poor clinical outcome in major trauma.

Comparing fine-scale temporal environmental DNA (eDNA) sampling to camera trapping for detecting mammalian carnivores (2021)
Thesis
Bolton, P. Comparing fine-scale temporal environmental DNA (eDNA) sampling to camera trapping for detecting mammalian carnivores. (Dissertation). University of Salford

Anthropogenic pressures have caused global species declines, making accurate biodiversity monitoring essential in providing data to help avert extinctions. One-fifth of mammalian species globally are classed as under threat which means a rapid, relia... Read More about Comparing fine-scale temporal environmental DNA (eDNA) sampling to camera trapping for detecting mammalian carnivores.

Building the resilience of Iranian hospitals to earthquake & flood disasters (2021)
Thesis
Salamati Nia, S. Building the resilience of Iranian hospitals to earthquake & flood disasters. (Thesis). University of Salford

For the last four decades, Iran has been experiencing an unprecedented series of disasters and has given rise to increased attention by policymakers to the country's arrangements for disaster management. A disaster event can be a severe disruption to... Read More about Building the resilience of Iranian hospitals to earthquake & flood disasters.

A framework to enhance the adoption of building information modelling amongst Sri Lankan quantity surveying organisations to increase the accuracy of pre-tender cost estimates (2021)
Thesis
Rathnayake, A. A framework to enhance the adoption of building information modelling amongst Sri Lankan quantity surveying organisations to increase the accuracy of pre-tender cost estimates. (Thesis). University of Salford

For decades, construction projects around the globe have been suffered to complete on budget due to ongoing cost overruns. Accordingly, both developed and developing countries have reported a number of construction projects that have resulted in incr... Read More about A framework to enhance the adoption of building information modelling amongst Sri Lankan quantity surveying organisations to increase the accuracy of pre-tender cost estimates.

An emergency preparedness framework for Sand and Dust Storms (SDSs) in Kuwait (2021)
Thesis
Dust Storms (SDSs) in Kuwait. (Thesis). University of Salford

Background The current literature suggests that there is a lack of preparedness framework for Sand and Dust Storms (SDSs) globally and regionally and the existing disaster response strategies are not fit for purpose. Evidence suggests that research... Read More about An emergency preparedness framework for Sand and Dust Storms (SDSs) in Kuwait.