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All Outputs (789)

Novel cyanocombretastatins as potent tubulin polymerisation inhibitors (2012)
Journal Article
Jalily, P., Hirst, N., Hadfield, J., & Rossington, S. (2012). Novel cyanocombretastatins as potent tubulin polymerisation inhibitors. Bioorganic and Medicinal Chemistry Letters, 22(21), 6731-6734. https://doi.org/10.1016/j.bmcl.2012.08.089

A series of novel cyanocombretastatins bearing a 3,4,5-trimethoxyphenyl moiety combined with a variety of substituted phenyl rings, were synthesised and their antitumour activity was evaluated. The Z-cyanocombretastatins were synthesised in a one-ste... Read More about Novel cyanocombretastatins as potent tubulin polymerisation inhibitors.

A midwives guide to Turner syndrome (2012)
Journal Article
Hollins-Martin, C., & Smythe, A. (2012). A midwives guide to Turner syndrome. British Journal of Midwifery, 20(9), 540-543

Turner syndrome (TS) is a cross-cultural genetic disorder that affects around 1 in 2500 women and is predominately associated with short stature and infertility. Classic TS occurs when one sex chromosome is missing (written as 45,X). In mosaic TS the... Read More about A midwives guide to Turner syndrome.

In cardiac ventricular myocytes correction of severe leak from the sarcoplasmic reticulum increases the amplitude and the rate of decay of the systolic calcium transient (2012)
Presentation / Conference Contribution

INTRODUCTION: In cardiac muscle the amplitude and duration of the systolic calcium (Ca) transient and thence contraction are modulated by the release and re-uptake of Ca from the sarcoplasmic reticulum (SR). In heart failure there is a decrease in bo... Read More about In cardiac ventricular myocytes correction of severe leak from the sarcoplasmic reticulum increases the amplitude and the rate of decay of the systolic calcium transient.

Modulation of ryanodine receptor open probability has no maintained effect on the amplitude of systolic calcium release in sheep or dog ventricular myocytes (2012)
Presentation / Conference Contribution

Caffeine is frequently used as an agent to increase the open probability of the Ryanodine receptor (RyR). However, our group has previously demonstrated that in rat, application of 500 µM caffeine has no sustained effect on systolic Ca. Rather, follo... Read More about Modulation of ryanodine receptor open probability has no maintained effect on the amplitude of systolic calcium release in sheep or dog ventricular myocytes.

Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer (2012)
Journal Article

p63 inhibits metastasis. Here, we show that p63 (both TAp63 and ΔNp63 isoforms) regulates expression of miR-205 in prostate cancer (PCa) cells, and miR-205 is essential for the inhibitory effects of p63 on markers of epithelial–mesenchymal transition... Read More about Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer.

A Medical e-Learning Development Training Program for Healthcare Professionals and e-Learning Resource (2012)
Presentation / Conference
Huang, K. H. (2012, September). A Medical e-Learning Development Training Program for Healthcare Professionals and e-Learning Resource. Presented at A Medical e-Learning Development Training Program for Healthcare Professionals, College of Health and Social Care, University of Salford

Presentation by Kuo Hung (Daniel) Huang, Department of e-Learning Design and Management, Chiayi National University, Taiwan to the College of Health and Social Care, University of Salford, 3rd September 2012.

Includes an example of an e-learning... Read More about A Medical e-Learning Development Training Program for Healthcare Professionals and e-Learning Resource.

Investment appraisal tools and sustainability evaluation in social housing (2012)
Presentation / Conference
Higham, A., & Fortune, C. (2012, September). Investment appraisal tools and sustainability evaluation in social housing. Presented at Association of Researchers in Construction Management (ARCOM) 28th Annual Conference, Edinburgh

Conventional decision making in all aspects of the asset management sector has largely been based around the key concepts of risk reduction and maximization of returns. Yet the RICS (2009) has called for surveying professionals to significantly modif... Read More about Investment appraisal tools and sustainability evaluation in social housing.

Attaining zero defects within Building Schools for the Future : A realistic target or a Sisyphean task? (2012)
Presentation / Conference
Higham, A., Boothman, J., & Horsfall, B. (2012, September). Attaining zero defects within Building Schools for the Future : A realistic target or a Sisyphean task?. Presented at 27th Annual Association of Researchers in Construction Management (ARCOM) Conference, Edinburgh, UK

Until its demise in July 2010 The Building Schools for the Future (BSF) programme represented the biggest single UK government investment in school buildings for more than 50 years. One of the key goals of the investment programme was the desire to e... Read More about Attaining zero defects within Building Schools for the Future : A realistic target or a Sisyphean task?.

Engaging life in two Irish nursing home units for people with dementia : quantitative comparisons before and after implementing household environments (2012)
Journal Article
Morgan_Brown, M., Ormerod, M., & Newton, R. (2012). Engaging life in two Irish nursing home units for people with dementia : quantitative comparisons before and after implementing household environments. Aging & mental health, 17(1), 57-65. https://doi.org/10.1080/13607863.2012.717250

This study compares the Social Engagement and Interactive Occupation of residents with dementia in two Irish nursing homes, before and after conversion to a household model environment. The changes were an open plan design and a functioning unit kitc... Read More about Engaging life in two Irish nursing home units for people with dementia : quantitative comparisons before and after implementing household environments.

The role of the anaesthetised guinea-pig in the preclinical cardiac safety evaluation of drug candidate compounds (2012)
Journal Article

Despite rigorous preclinical and clinical safety evaluation, adverse cardiac effects remain a leading cause of drug attrition and post-approval drug withdrawal. A number of cardiovascular screens exist within preclinical development. These screens do... Read More about The role of the anaesthetised guinea-pig in the preclinical cardiac safety evaluation of drug candidate compounds.

Impacts of flooding on SMEs and their relevance to chartered surveyors : final report of the developing flood expert knowledge in chartered surveyors - DEFENCES project (2012)
Report
Wedawatta, H., Ingirige, B., & Proverbs, D. (2012). Impacts of flooding on SMEs and their relevance to chartered surveyors : final report of the developing flood expert knowledge in chartered surveyors - DEFENCES project

The UK has endured a number of major flood events in
recent years, and the UK Environment Agency (2009a)
identified that about 5.2million properties in England,
amounting to one in six, are at risk of flooding. The impacts of flooding include d... Read More about Impacts of flooding on SMEs and their relevance to chartered surveyors : final report of the developing flood expert knowledge in chartered surveyors - DEFENCES project.

A transatlantic comparative study of acute dysphagia services (2012)
Journal Article
Newman, R., & Long, T. (2012). A transatlantic comparative study of acute dysphagia services. American journal of medicine and medical sciences (Print), 2(5), 96-102. https://doi.org/10.5923/j.ajmms.20120205.02

This was the first study to compare acute dysphagia service provision directly between the UK and the US. It examined variations in acute dysphagia services between the UK and the US, determined clinicians’ perceptions of their own service and that o... Read More about A transatlantic comparative study of acute dysphagia services.

Perceptions of psychotherapy trainees of psychotherapy research (2012)
Journal Article
Widdowson, M. (2012). Perceptions of psychotherapy trainees of psychotherapy research. Counselling and Psychotherapy Research, 12(3), 178-186. https://doi.org/10.1080/14733145.2012.697473

The research-practice gap and lack of engagement with research by trainees and qualified therapists is a widely discussed issue amongst psychotherapy researchers. The present study investigates the perceptions of psychotherapy trainees of psychothera... Read More about Perceptions of psychotherapy trainees of psychotherapy research.

Time domain analysis of Helmholtz soliton propagation using the TLM method (2012)
Journal Article
Chamorro-Posada, P., & McDonald, G. (2012). Time domain analysis of Helmholtz soliton propagation using the TLM method. Journal of Nonlinear Optical Physics and Materials, 21(03), https://doi.org/10.1142/S0218863512500312

The transmission line matrix method is used to study Helmholtz solitons as solutions of the two-dimensional time-domain Maxwell equations in nonlinear media. This approach permits to address, in particular, the propagation and intrinsic stability pr... Read More about Time domain analysis of Helmholtz soliton propagation using the TLM method.