pH plays a role in the mode of action of trimethoprim on Escherichia coli
(2018)
Journal Article
AlRabiah, H., Allwood, J., Correa, E., Xu, Y., & Goodacre, R. (2018). pH plays a role in the mode of action of trimethoprim on Escherichia coli. PLoS ONE, 13(7), e0200272. https://doi.org/10.1371/journal.pone.0200272
Metabolomics-based approaches were applied to understand interactions of trimethoprim with Escherichia coli K-12 at sub-minimum inhibitory concentrations (MIC≈0.2, 0.03 and 0.003 mg L-1). Trimethoprim inhibits dihydrofolate reductase and thereby is a... Read More about pH plays a role in the mode of action of trimethoprim on Escherichia coli.