All Outputs (2)

A myristoyl amide derivative of doxycycline potently targets cancer stem cells (CSCs) and prevents metastasis, without retaining antibiotic activity (2020)
Journal Article
Ozsvari, B., Magalhaes, L., Latimer, J., Kangasmetsa, J., Sotgia, F., & Lisanti, M. (2020). A myristoyl amide derivative of doxycycline potently targets cancer stem cells (CSCs) and prevents metastasis, without retaining antibiotic activity. Frontiers in Oncology, 10, 1528. https://doi.org/10.3389/fonc.2020.01528

Here, we describe the chemical synthesis and biological activity of a new Doxycycline derivative, designed specifically to more effectively target cancer stem cells (CSCs). In this analogue, a myristic acid (14 carbon) moiety is covalently attached t... Read More about A myristoyl amide derivative of doxycycline potently targets cancer stem cells (CSCs) and prevents metastasis, without retaining antibiotic activity.

The efficacy and adverse events of delafloxacin for treating acute bacterial skin and skin structure infections : a systematic review and meta-analysis (2020)
Journal Article
Qasim, S., Tanvir, S., Latimer, J., Qamar, Z., & Niazi, F. (2020). The efficacy and adverse events of delafloxacin for treating acute bacterial skin and skin structure infections : a systematic review and meta-analysis. Journal of Pharmacy and Bioallied Sciences, 12(5), 538-545. https://doi.org/10.4103/jpbs.JPBS_154_20

Background: Acute bacterial skin and skin structure infections (ABSSSI) cause significant morbidity and mortality in hospitalized patients and outpatients as well. Newer fluoroquinolones such as delafloxacin might be a useful medication for treating... Read More about The efficacy and adverse events of delafloxacin for treating acute bacterial skin and skin structure infections : a systematic review and meta-analysis.