A global catalog of whole-genome diversity from 233 primate species.

Kuderna, Lukas F K; Gao, Hong; Janiak, Mareike C; Kuhlwilm, Martin; Orkin, Joseph D; Bataillon, Thomas; Manu, Shivakumara; Valenzuela, Alejandro; Bergman, Juraj; Rousselle, Marjolaine; Silva, Felipe Ennes; Agueda, Lidia; Blanc, Julie; Gut, Marta; de Vries, Dorien; Goodhead, Ian; Harris, R Alan; Raveendran, Muthuswamy; Jensen, Axel; Chuma, Idrissa S; Horvath, Julie E; Hvilsom, Christina; Juan, David; Frandsen, Peter; Schraiber, Joshua G.; de Melo, Fabiano R; Bertuol, Fabrício; Byrne, Hazel; Sampaio, Iracilda; Farias, Izeni; Valsecchi, João; Messias, Malu; da Silva, Maria N F; Trivedi, Mihir; Rossi, Rogerio; Hrbek, Tomas; Andriaholinirina, Nicole; Rabarivola, Clément J.; Zaramody, Alphonse; Jolly, Clifford J.; Phillips-Conroy, Jane; Wilkerson, Gregory; Abee, Christian; Simmons, Joe H; Fernandez-Duque, Eduardo; Kanthaswamy, Sree; Shiferaw, Fekadu; Wu, Dongdong; Zhou, Long; Shao, Yong; Zhang, Guojie; Keyyu, Julius D; Knauf, Sascha; Le, Minh D; Lizano, Esther; Merker, Stefan; Navarro, Arcadi; Nadler, Tilo; Khor, Chiea Chuen; Lee, Jessica; Tan, Patrick; Lim, Weng Khong; Kitchener, Andrew C; Zinner, Dietmar; Gut, Ivo; Melin, Amanda D; Guschanski, Katerina; Schierup, Mikkel Heide; Beck, Robin M D; Umapathy, Govindhaswamy; Roos, Christian; Boubli, Jean P; Rogers, Jeffrey; Farh, Kyle Kai-How; Marques Bonet, Tomas; Schraiber, Joshua G; Rabarivola, Clément J; Jolly, Clifford J

doi:10.1126/science.abn7829

All Outputs (4)

Identification of constrained sequence elements across 239 primate genomes. (2023)
Journal Article
Kuderna, L. F., Ulirsch, J. C., Rashid, S., Ameen, M., Sundaram, L., Hickey, G., …Farh, K. K. (2023). Identification of constrained sequence elements across 239 primate genomes. Nature, 36, https://doi.org/10.1038/s41586-023-06798-8

Noncoding DNA is central to our understanding of human gene regulation and complex diseases , and measuring the evolutionary sequence constraint can establish the functional relevance of putative regulatory elements in the human genome . Identifying... Read More about Identification of constrained sequence elements across 239 primate genomes..

Determining management strategies to control ash dieback disease through molecular and environmental interactions (2023)
Thesis
Raykova, A. (2023). Determining management strategies to control ash dieback disease through molecular and environmental interactions. (Thesis). University of Salford

Forest trees have been increasingly threatened by invasive pathogens, endangering associated biodiversity, and reducing ecosystems. Such an alien pathogen, Hymenoscyphus fraxineus, has had considerable impacts on the common ash tree (Fraxinus exce... Read More about Determining management strategies to control ash dieback disease through molecular and environmental interactions.

The landscape of tolerated genetic variation in humans and primates. (2023)
Journal Article
Gao, H., Hamp, T., Ede, J., Schraiber, J. G., McRae, J., Singer-Berk, M., …Jolly, C. J. (2023). The landscape of tolerated genetic variation in humans and primates. Science, 380(6648), https://doi.org/10.1126/science.abn8197

Personalized genome sequencing has revealed millions of genetic differences between individuals, but our understanding of their clinical relevance remains largely incomplete. To systematically decipher the effects of human genetic variants, we obtain... Read More about The landscape of tolerated genetic variation in humans and primates..

A global catalog of whole-genome diversity from 233 primate species. (2023)
Journal Article
Kuderna, L. F. K., Gao, H., Janiak, M. C., Kuhlwilm, M., Orkin, J. D., Bataillon, T., …Jolly, C. J. (2023). A global catalog of whole-genome diversity from 233 primate species. Science, 380(6648), 906-913. https://doi.org/10.1126/science.abn7829

The rich diversity of morphology and behavior displayed across primate species provides an informative context in which to study the impact of genomic diversity on fundamental biological processes. Analysis of that diversity provides insight into lon... Read More about A global catalog of whole-genome diversity from 233 primate species..