Pathogenicity and protective immunogenicity of cysteine proteinase-deficient mutants of Leishmania mexicana in non-murine models
(2006)
Journal Article
Saravia, N., Escoria, B., Osorio, Y., Valderramaa, L., Brooks, D., Arteaga, L., …Travi, B. (2006). Pathogenicity and protective immunogenicity of cysteine proteinase-deficient mutants of Leishmania mexicana in non-murine models. Vaccine, 24(19), 4247-4259. https://doi.org/10.1016/j.vaccine.2005.05.045
This study demonstrates that deletion of cysteine proteinase (CP) genes diminishes pathogenicity of Leishmania mexicana in non-murine experimental host models while preserving immunogenicity. Both cpb and cpa/cpb-deficient lines induced delayed disea... Read More about Pathogenicity and protective immunogenicity of cysteine proteinase-deficient mutants of Leishmania mexicana in non-murine models.