Outputs (21)

Trogocytosis: revealing new insights into parasite–host interactions (2025)
Journal Article

Trogocytosis – a process whereby cells physically nibble and ingest membrane fragments and other components from neighboring cells – plays a critical role in host–parasite interactions by modulating parasite survival and host immune responses. This r... Read More about Trogocytosis: revealing new insights into parasite–host interactions.

Characterization of a trypanosome from large yellow croaker (Larimichthys crocea), cage-cultured in seawater, in China (2025)
Journal Article

A significant outbreak of trypanosomosis occurred in farmed large yellow croaker (Larimichthys crocea) in Southeast China resulting in daily mortality rates, over 70 days, of up to 1 % with cumulative losses nearing 60 %. Despite the severity of the... Read More about Characterization of a trypanosome from large yellow croaker (Larimichthys crocea), cage-cultured in seawater, in China.

Revealing the progression and pathologic features of intraperitoneal infection of Trichomonas vaginalis in mice via parasite α-actinin-based immunological detection (2024)
Journal Article

Background: Trichomoniasis caused by Trichomonas vaginalis is the most prevalent nonviral sexually transmitted disease in women and has frequently damaged public health. To better use the animal model and take a step forward fully elucidating this pa... Read More about Revealing the progression and pathologic features of intraperitoneal infection of Trichomonas vaginalis in mice via parasite α-actinin-based immunological detection.

Toxoplasma gondii (2024)
Other

Multiomics of parkinsonism cynomolgus monkeys highlights significance of metabolites in interaction between host and microbiota (2024)
Journal Article

The gut microbiota has been demonstrated to play a significant role in the pathogenesis of Parkinson’s disease (PD). However, conflicting findings regarding specific microbial species have been reported, possibly due to confounding factors within hum... Read More about Multiomics of parkinsonism cynomolgus monkeys highlights significance of metabolites in interaction between host and microbiota.

First outbreak of trypanosomiasis in farmed blood parrot cichlids (Vieja melanura♀ × Amphilophus citrinellus♂) from southern China (2024)
Journal Article

Outbreaks of fish trypanosomiasis are regularly reported in cultured groupers (Epinephelus spp.), largemouth bass (Micropterus salmoides), and many other species of Cyprinidae, but only rarely reported in ornamental fish. This study reports a trypano... Read More about First outbreak of trypanosomiasis in farmed blood parrot cichlids (Vieja melanura♀ × Amphilophus citrinellus♂) from southern China.

The Toxoplasma monocarboxylate transporters are involved in the metabolism within the apicoplast and are linked to parasite survival (2024)
Journal Article

The apicoplast is a four-membrane plastid found in the apicomplexans, which harbors biosynthesis and organelle housekeeping activities in the matrix. However, the mechanism driving the flux of metabolites, in and out, remains unknown. Here, we used T... Read More about The Toxoplasma monocarboxylate transporters are involved in the metabolism within the apicoplast and are linked to parasite survival.

PAG3 promotes the differentiation of bloodstream forms in Trypanosoma brucei and reveals the evolutionary relationship among the Trypanozoon trypanosomes (2022)
Journal Article

Introduction: Trypanosoma brucei, T. evansi and T. equiperdum are members of the subgenus Trypanozoon and are highly similar morphologically and genetically. The main differences between these three species are their differentiation patterns in the h... Read More about PAG3 promotes the differentiation of bloodstream forms in Trypanosoma brucei and reveals the evolutionary relationship among the Trypanozoon trypanosomes.

Novel insertions in the mitochondrial maxicircle of Trypanosoma musculi, a mouse trypanosome (2022)
Journal Article

Trypanosoma musculi is a, globally distributed, mouse-specific haemoflagellate, of the family Trypanosomatidae, which shares similar characteristics in morphology with Trypanosoma lewisi. The kinetoplast (mitochondrial) DNA of Trypanosomatidae flagel... Read More about Novel insertions in the mitochondrial maxicircle of Trypanosoma musculi, a mouse trypanosome.

Nile tilapia (Oreochromis niloticus) can be experimentally infected with both marine and freshwater fish trypanosomes. (2022)
Journal Article

Trypanosomes are haemoflagellates found in vertebrate species and many of them can cause death in infected hosts including fish and humans. With the development of high-density farming in marine and freshwater fish aquaculture systems, severe disease... Read More about Nile tilapia (Oreochromis niloticus) can be experimentally infected with both marine and freshwater fish trypanosomes..

iNOS is essential to maintain a protective Th1/Th2 response and the production of cytokines/chemokines against Schistosoma japonicum infection in rats (2022)
Journal Article

Humans and a wide range of mammals are generally susceptible to Schistosoma infection, while some rodents such as Rattus rats and Microtus spp are not. We previously demonstrated that inherent high expression levels of nitric oxide (NO), produced by... Read More about iNOS is essential to maintain a protective Th1/Th2 response and the production of cytokines/chemokines against Schistosoma japonicum infection in rats.

The occurrence of malignancy in Trypanosoma brucei brucei by rapid passage in mice (2022)
Journal Article

Pleomorphic Trypanosoma brucei are best known for their tightly controlled cell growth and developmental program, which ensures their transmissibility and host fitness between the mammalian host and insect vector. However, after long-term adaptation... Read More about The occurrence of malignancy in Trypanosoma brucei brucei by rapid passage in mice.

Species identification and phylogenetic analysis of Leishmania isolated from patients, vectors and hares in the Xinjiang Autonomous Region, The People's Republic of China (2021)
Journal Article

Visceral leishmaniasis (VL) has been declared as one of the six major tropical diseases by the World Health Organization. This disease has been successfully controlled in China, except for some areas in the western region, such as the Xinjiang Autono... Read More about Species identification and phylogenetic analysis of Leishmania isolated from patients, vectors and hares in the Xinjiang Autonomous Region, The People's Republic of China.

A new species of mammalian trypanosome, Trypanosoma (Megatrypanum) bubalisi sp. nov., found in the freshwater leech Hirudinaria manillensis (2021)
Journal Article

Leeches have long been considered potential vectors for the aquatic lineage of trypanosomes, while bloodsucking insects are generally considered as the vectors for the terrestrial lineage of trypanosomes. The freshwater leech, Hirudinaria manillensis... Read More about A new species of mammalian trypanosome, Trypanosoma (Megatrypanum) bubalisi sp. nov., found in the freshwater leech Hirudinaria manillensis.

Innate resistance to Leishmania amazonensis Infection in rat is dependent on NOS2 (2021)
Journal Article

Leishmania infection causes diverse clinical manifestations in humans. The disease outcome is complicated by the combination of many host and parasite factors. Inbred mouse strains vary in resistance to Leishmania major but are highly susceptible to... Read More about Innate resistance to Leishmania amazonensis Infection in rat is dependent on NOS2.

High resistance to Toxoplasma gondii infection in inducible nitric oxide synthase (iNOS) knockout rats (2021)
Journal Article

Nitric oxide (NO) is an important immune molecule which acts against extra- and intracellular pathogens in most hosts. However, after knockout of inducible nitric oxide synthase (iNOS-/-) in Sprague Dawley (SD) rats, these iNOS-/- rats were found to... Read More about High resistance to Toxoplasma gondii infection in inducible nitric oxide synthase (iNOS) knockout rats.

The relationship between the infection of Toxoplasma gondii and Alzheimer’s disease (2021)
Thesis

Toxoplasma gondii is a zoonotic parasite that commonly causes infections in a variety of warm-blooded animals including humans. This parasite causes a disease referred to as toxoplasmosis. T. gondii infections are known to have a significant impact o... Read More about The relationship between the infection of Toxoplasma gondii and Alzheimer’s disease.

Identification of an orally active carbazole aminoalcohol derivative with broad-spectrum anti-animal trypanosomiasis activity (2021)
Journal Article

Animal trypanosomiasis, caused by the members of subgenus Trypanozoon (Trypanosoma brucei brucei, T. evansi and T. equiperdum), has reduced animal productivity leading to significant negative economic impacts in endemic regions. Due to limited drug d... Read More about Identification of an orally active carbazole aminoalcohol derivative with broad-spectrum anti-animal trypanosomiasis activity.

Parasites as disruptors : from ecology and evolution, through cell and molecular biology to clinical and veterinary medicine (2021)
Journal Article

Editorial.

An investigation into Toxoplasma gondii infection and the expression of Arginase-1 and iNOS in human lung tissue (2021)
Thesis

This study aimed to investigate the relationship between Toxoplasma gondii infection and the expression of the immune modulating proteins Arginase-1 and iNOS in human lung biopsy samples. Previously, a 100% toxoplasmosis infection rate was found in 7... Read More about An investigation into Toxoplasma gondii infection and the expression of Arginase-1 and iNOS in human lung tissue.