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Human cystic echinococcosis in two Mongolian communities in Hobukesar (China) and Bulgan (Mongolia). (2005)
Journal Article
Craig, P., Wang, Y., Zhang, W., Zhou, H., He, T., Rogan, M., …Mukhar, T. (2005). Human cystic echinococcosis in two Mongolian communities in Hobukesar (China) and Bulgan (Mongolia). Transactions of The Royal Society of Tropical Medicine and Hygiene, 99(9), 692-698. https://doi.org/10.1016/j.trstmh.2005.01.004

In order to investigate the prevalence of human cystic echinococcosis (CE) in traditional Mongolian communities in western Mongolia and Xinjiang (northwest China), studies were carried out between 1995 and 2000, on two ethnically identical population... Read More about Human cystic echinococcosis in two Mongolian communities in Hobukesar (China) and Bulgan (Mongolia)..

Use of a compound having two gold (1) atoms each covalently bonded to a carbon atom in a covalent link connecting the two gold (1) atoms for the treatment of cancer (2005)
Patent
McGown, A., & Flower, K. (2005). Use of a compound having two gold (1) atoms each covalently bonded to a carbon atom in a covalent link connecting the two gold (1) atoms for the treatment of cancer

The invention relates to the treatment of cancers, in particular, cancers that are resistant to platinum based chemotherapeutic agents. A pharmaceutical composition for the treatment of cancer comprising an effective amount of a compound having two g... Read More about Use of a compound having two gold (1) atoms each covalently bonded to a carbon atom in a covalent link connecting the two gold (1) atoms for the treatment of cancer.

Synthesis and evaluation of double bond substituted combretastatins (2005)
Journal Article
Hadfield, J., Gaukroger, K., Hirst, N., Weston, A., Lawrence, N., & McGown, A. (2005). Synthesis and evaluation of double bond substituted combretastatins. European Journal of Medicinal Chemistry, 40(6), 529-541. https://doi.org/10.1016/j.ejmech.2004.12.008

A series of combretastatins substituted with epoxides, amides and small alkyl groups has been synthesised and evaluated for cytotoxicity and their ability to inhibit the assembly of tubulin. The methyl and ethyl substituted phenols 36, 44 have shown... Read More about Synthesis and evaluation of double bond substituted combretastatins.

Preclinical evaluation of the pharmacodynamic properties of 2,5-diaziridinyl-3-hydroxymethyl-6-methyl-1,4-benzoquinone (2005)
Journal Article
Ward, T., Danson, S., McGown, A., Ranson, M., Coe, N., Jayson, G., …Butler, J. (2005). Preclinical evaluation of the pharmacodynamic properties of 2,5-diaziridinyl-3-hydroxymethyl-6-methyl-1,4-benzoquinone. Clinical Cancer Research, 11(7), 2695-2701. https://doi.org/10.1158/1078-0432.CCR-04-1751

Purpose: The purpose of our study was to investigate the cellular accumulation, DNA cross-linking ability, and cellular toxicity of RH1 (2,5-diaziridinyl-3-[hydroxymethyl[-6-methyl-1,4-benzoquinone), a novel DNA alkylating agent currently in clinical... Read More about Preclinical evaluation of the pharmacodynamic properties of 2,5-diaziridinyl-3-hydroxymethyl-6-methyl-1,4-benzoquinone.

Identification and reactivity of the triplet excited state of 5-hydroxytryptophan (2005)
Journal Article
Dad, S., Bisby, R., Clark, I., & Parker, A. (2005). Identification and reactivity of the triplet excited state of 5-hydroxytryptophan. Journal of Photochemistry and Photobiology B: Biology, 78(3), 245-251. https://doi.org/10.1016/j.jphotobiol.2004.11.013

Both the neurotransmitter serotonin and the unnatural amino acid 5-hydroxytryptophan (5HT), contain the 5-hydroxyindole chromophore. The photochemistry of 5HT is being investigated in relation to the multiphoton excitation of this chromophore to prod... Read More about Identification and reactivity of the triplet excited state of 5-hydroxytryptophan.

Potential role for 8-oxoguanine DNA glycosylase in regulating inflammation (2005)
Journal Article
Mabley, J., Pacher, P., Deb, A., Wallace, R., Elder, R., & Szabó, C. (2005). Potential role for 8-oxoguanine DNA glycosylase in regulating inflammation. FASEB Journal, 19(2), 290-2. https://doi.org/10.1096/fj.04-2278fje

OGG-1 DNA glycosylase (OGG-1) is an enzyme involved in DNA repair. It excises 7,8-dihydro-8-oxoguanine, which is formed by oxidative damage of guanine. We have investigated the role of OGG-1 in inflammation using three models of inflammation: endotox... Read More about Potential role for 8-oxoguanine DNA glycosylase in regulating inflammation.

Differential CTLs specific for prostate-specific antigen in healthy donors and patients with prostate cancer (2005)
Journal Article
Elkord, E., Williams, P., Kynaston, H., & Rowbottom, A. (2005). Differential CTLs specific for prostate-specific antigen in healthy donors and patients with prostate cancer. International Immunology, 17(10), 1315-1325. https://doi.org/10.1093/intimm/dxh309

Induction of CTL responses specific for prostate-specific antigen (PSA)-derived peptides in healthy individuals and patients with prostate cancer (PC) was investigated. Eight PSA-derived peptides that have the potential to bind HLA-A2 molecules were... Read More about Differential CTLs specific for prostate-specific antigen in healthy donors and patients with prostate cancer.

Human monocyte isolation methods influence cytokine production from in vitro generated dendritic cells (2005)
Journal Article
Elkord, E., Williams, P., Kynaston, H., & Rowbottom, A. (2005). Human monocyte isolation methods influence cytokine production from in vitro generated dendritic cells. Immunology, 114(2), 204-212. https://doi.org/10.1111/j.1365-2567.2004.02076.x

There is growing interest in the in vitro generation of dendritic cells (DC) from peripheral blood monocytes, but the effect of the method chosen to isolate CD14+ monocytes for subsequent DC generation is poorly documented. The method used to isolate... Read More about Human monocyte isolation methods influence cytokine production from in vitro generated dendritic cells.