Promising investigational drug candidates in phase I and phase II clinical trials for mesothelioma (2017)
Journal Article
Guazzelli, A., Bakker, E., Tian, K., Demonacos, C., Krstic- Demonacos, M., & Mutti, L. (2017). Promising investigational drug candidates in phase I and phase II clinical trials for mesothelioma. Expert Opinion on Investigational Drugs, 26(8), 933-944. https://doi.org/10.1080/13543784.2017.1351545

Introduction: Malignant mesothelioma is a rare and lethal malignancy primarily affecting the pleura and peritoneum. Mesothelioma incidence is expected to increase worldwide and current treatments remain ineffective, leading to poor prognosis. Within... Read More about Promising investigational drug candidates in phase I and phase II clinical trials for mesothelioma.

Mitoriboscins : mitochondrial-based therapeutics targeting cancer stem cells (CSCs), bacteria and pathogenic yeast (2017)
Journal Article
Ozsvari, B., Fiorillo, M., Bonuccelli, G., Cappello, A., Frattaruolo, L., Sotgia, F., …Lisanti, M. (2017). Mitoriboscins : mitochondrial-based therapeutics targeting cancer stem cells (CSCs), bacteria and pathogenic yeast. Oncotarget, 2017(8), 67457-67472. https://doi.org/10.18632/oncotarget.19084

The “endo-symbiotic theory of mitochondrial evolution” states that mitochondrial organelles evolved from engulfed aerobic bacteria, after millions of years of symbiosis and adaptation. Here, we have exploited this premise to design new antibiotics an... Read More about Mitoriboscins : mitochondrial-based therapeutics targeting cancer stem cells (CSCs), bacteria and pathogenic yeast.

Novel therapies for cancer treatment : designing high affinity selective ligands against SIRT1 enzyme (2017)
Thesis
Al-Sudani, B. Novel therapies for cancer treatment : designing high affinity selective ligands against SIRT1 enzyme. (Thesis). University of Salford

The word ‘Sirtuin’ or Sir2 proteins are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase. SIRT1 is the most studied mammalian Sirtuins and predominantly localised in the nucleus and cyt... Read More about Novel therapies for cancer treatment : designing high affinity selective ligands against SIRT1 enzyme.

ESPEN expert group recommendations for action against cancer-related malnutrition (2017)
Journal Article
Arends, J., Baracos, V., Bertz, H., Bozzetti, F., Calder, P., Deutz, N., …Weimann, A. (2017). ESPEN expert group recommendations for action against cancer-related malnutrition. Clinical Nutrition, 36(5), 1187-1196. https://doi.org/10.1016/j.clnu.2017.06.017

Patients with cancer are at particularly high risk for malnutrition because both the disease and its treatments threaten their nutritional status. Yet cancer-related nutritional risk is sometimes overlooked or under-treated by clinicians, patients, a... Read More about ESPEN expert group recommendations for action against cancer-related malnutrition.

Systolic [Ca2+ ]i regulates diastolic levels in rat ventricular myocytes (2017)
Journal Article
Sankaranarayanan, R., Kistamas, K., Greensmith, D., Venetucci, L., & Eisner, D. (2017). Systolic [Ca2+ ]i regulates diastolic levels in rat ventricular myocytes. Journal of Physiology, 595(16), 5545-5555. https://doi.org/10.1113/JP274366

[Ca2+]i must be low enough in diastole so that the ventricle is relaxed and can refill with blood. Interference with this will impair relaxation. The factors responsible for regulation of diastolic [Ca2+]i, in particular the relative roles of the sar... Read More about Systolic [Ca2+ ]i regulates diastolic levels in rat ventricular myocytes.

Targeting hypoxic cancer stem cells (CSCs) with Doxycycline : implications for optimizing anti-angiogenic therapy (2017)
Journal Article
implications for optimizing anti-angiogenic therapy. Oncotarget, 2017(8), 56126-56142. https://doi.org/10.18632/oncotarget.18445

Here, we report new mechanistic insight into how chronic hypoxia increases ‘stemness’ in cancer cells. Using chemical inhibitors, we provide direct experimental evidence that ROS production and mitochondrial biogenesis are both required for the hypox... Read More about Targeting hypoxic cancer stem cells (CSCs) with Doxycycline : implications for optimizing anti-angiogenic therapy.

Deregulation of miRNAs in malignant pleural mesothelioma is associated with prognosis and suggests an alteration of cell metabolism (2017)
Journal Article
De Santi, C., Melaiu, O., Bonotti, A., Cascione, L., Di Leva, G., Foddis, R., …Landi, S. (2017). Deregulation of miRNAs in malignant pleural mesothelioma is associated with prognosis and suggests an alteration of cell metabolism. Scientific reports, 7(2017), #3140. https://doi.org/10.1038/s41598-017-02694-0

Malignant pleural mesothelioma (MPM) is an aggressive human cancer and miRNAs can play a key-role for this disease. In order to broaden the knowledge in this field, the miRNA expression was investigated in a large series of MPM to discover new pathwa... Read More about Deregulation of miRNAs in malignant pleural mesothelioma is associated with prognosis and suggests an alteration of cell metabolism.

Vitamin C and Doxycycline : a synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs) (2017)
Journal Article
De Francesco, E., Bonuccelli, G., Maggiolini, M., Sotgia, F., & Lisanti, M. (2017). Vitamin C and Doxycycline : a synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs). Oncotarget, 2017(8), 67269-67286. https://doi.org/10.18632/oncotarget.18428

Here, we developed a new synthetic lethal strategy for further optimizing the eradication of cancer stem cells (CSCs). Briefly, we show that chronic treatment with the FDA-approved antibiotic Doxycycline effectively reduces cellular respiration, by... Read More about Vitamin C and Doxycycline : a synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs).

Differential regulation of cell death pathways by the microenvironment correlates with chemoresistance and survival in leukaemia (2017)
Journal Article
Qattan, M., Bakker, E., Rajendran, R., Wei-Chen Chen, D., Saha, V., Liu, J., …Krstic- Demonacos, M. (2017). Differential regulation of cell death pathways by the microenvironment correlates with chemoresistance and survival in leukaemia. PLoS ONE, 12(6), e0178606. https://doi.org/10.1371/journal.pone.0178606

Glucocorticoids (GCs) and topoisomerase II inhibitors are used to treat acute lymphoblastic leukaemia (ALL) as they induce death in lymphoid cells through the glucocorticoid receptor (GR) and p53 respectively. Mechanisms underlying ALL cell death and... Read More about Differential regulation of cell death pathways by the microenvironment correlates with chemoresistance and survival in leukaemia.

Probing the action of a novel anti-leukaemic drug therapy at the single cell level using modern vibrational spectroscopy techniques (2017)
Journal Article
Denbigh, J., Perez-Guaita, D., Vernooij, R., Tobin, M., Bambery, K., Xu, Y., …Wood, B. (2017). Probing the action of a novel anti-leukaemic drug therapy at the single cell level using modern vibrational spectroscopy techniques. Scientific reports, 7(1), 2649. https://doi.org/10.1038/s41598-017-02069-5

Acute myeloid leukaemia (AML) is a life threatening cancer for which there is an urgent clinical need for novel therapeutic approaches. A redeployed drug combination of bezafibrate and medroxyprogesterone acetate (BaP) has shown anti-leukaemic activi... Read More about Probing the action of a novel anti-leukaemic drug therapy at the single cell level using modern vibrational spectroscopy techniques.

Hodgkin lymphoma : a complex metabolic ecosystem with glycolytic reprogramming of the tumor microenvironment (2017)
Journal Article
Mikkilineni, L., Whitaker-Menezes, D., Domingo-Vidal, M., Sprandio, J., Avena, P., Cotzia, P., …Martinez-Outschoorn, U. (2017). Hodgkin lymphoma : a complex metabolic ecosystem with glycolytic reprogramming of the tumor microenvironment. Seminars in Oncology, 44(3), 218-225. https://doi.org/10.1053/j.seminoncol.2017.10.003

Background Twenty percent of patients with classical Hodgkin Lymphoma (cHL) have aggressive disease defined as relapsed or refractory disease to initial therapy. At present we cannot identify these patients pre-treatment. The microenvironment is v... Read More about Hodgkin lymphoma : a complex metabolic ecosystem with glycolytic reprogramming of the tumor microenvironment.

Influence of size and shape on the anatomical distribution of endotoxin-free gold nanoparticles (2017)
Journal Article
Talamini, L., Violato, M. B., Cai, Q., Monopoli, M., Kantner, K., Krpetic, Z., …Bigini, P. (2017). Influence of size and shape on the anatomical distribution of endotoxin-free gold nanoparticles. ACS nano, 11(6), 5519-5529. https://doi.org/10.1021/acsnano.7b00497

The transport and the delivery of drugs through nanocarriers is a great challenge of pharmacology. Since the production of liposomes to reduce the toxicity of doxorubicin in patients, a plethora of nanomaterials have been produced and characterized.... Read More about Influence of size and shape on the anatomical distribution of endotoxin-free gold nanoparticles.

Dual functionality anti-reflection and biocidal coatings (2017)
Journal Article
Yates, H., Sheel, P., Hodgkinson, J., Warwick, M., Elfakhri, S., & Foster, H. (2017). Dual functionality anti-reflection and biocidal coatings. Surface and Coatings Technology, 324, 201-207. https://doi.org/10.1016/j.surfcoat.2017.05.077

A thin film combination of anti-reflection (AR) and biocidal properties would be of particular interest to reduce the transfer of infection and improve readability of public high use touch screens. In this paper we describe the development of a dual... Read More about Dual functionality anti-reflection and biocidal coatings.

A-to-I editing in human miRNAs is enriched in seed sequence, influenced by sequence contexts and significantly hypoedited in glioblastoma multiforme (2017)
Journal Article
Paul, D., Sinha, A., Ray, A., Lal, M., Nayak, S., Sharma, A., …Mukhopadhyay, A. (2017). A-to-I editing in human miRNAs is enriched in seed sequence, influenced by sequence contexts and significantly hypoedited in glioblastoma multiforme. Scientific reports, 7(2466), https://doi.org/10.1038/s41598-017-02397-6

Editing in microRNAs, particularly in seed can significantly alter the choice of their target genes. We show that out of 13 different human tissues, different regions of brain showed higher adenosine to inosine (A-to-I) editing in mature miRNAs. Thes... Read More about A-to-I editing in human miRNAs is enriched in seed sequence, influenced by sequence contexts and significantly hypoedited in glioblastoma multiforme.

The inhibition of FGF receptor 1 activity mediates sorafenib-induced antiproliferative effects in human mesothelioma tumor-initiating cells (2017)
Journal Article
Pattarozzi, A., Carra, E., Favoni, R., Würth, R., Marubbi, D., Filiberti, R., …Daga, A. (2017). The inhibition of FGF receptor 1 activity mediates sorafenib-induced antiproliferative effects in human mesothelioma tumor-initiating cells. Stem Cell Research and Therapy, 8(119), https://doi.org/10.1186/s13287-017-0573-7

Tumor-initiating cells (TICs), the subset of cells within tumors endowed with stem-like features, being highly resistant to conventional cytotoxic drugs, are the major cause of tumor relapse. The identification of molecules able to target TICs remain... Read More about The inhibition of FGF receptor 1 activity mediates sorafenib-induced antiproliferative effects in human mesothelioma tumor-initiating cells.

Current and prospective pharmacotherapies for the treatment of pleural mesothelioma (2017)
Journal Article
Bakker, E., Guazzelli, A., Krstic-Demonacos, M., Lisanti, M., Sotgia, F., & Mutti, L. (2017). Current and prospective pharmacotherapies for the treatment of pleural mesothelioma. Expert Opinion on Orphan Drugs, 5(6), 455-465. https://doi.org/10.1080/21678707.2017.1325358

Introduction: Mesothelioma is a rare asbestos-linked cancer with an expected incidence peak between 2015–2030. Therapies remain ineffective, thus developing and testing novel treatments is important for both oncologists and researchers. Areas co... Read More about Current and prospective pharmacotherapies for the treatment of pleural mesothelioma.

Mesothelin promoter variants are associated with increased soluble mesothelin-related peptide levels in asbestos-exposed individuals (2017)
Journal Article
De Santi, C., Pucci, P., Bonotti, A., Melaiu, O., Cipollini, M., Silvestri, R., …Landi, S. (2017). Mesothelin promoter variants are associated with increased soluble mesothelin-related peptide levels in asbestos-exposed individuals. Occupational and Environmental Medicine, 74(6), 457-464. https://doi.org/10.1136/oemed-2016-104024

BACKGROUND: Soluble mesothelin-related peptide (SMRP) is a promising diagnostic biomarker for malignant pleural mesothelioma (MPM), but various confounders hinder its usefulness in surveillance programmes. We previously showed that a single nucleoti... Read More about Mesothelin promoter variants are associated with increased soluble mesothelin-related peptide levels in asbestos-exposed individuals.

Genetic analyses of Chinese isolates of Toxoplasma gondii reveal a new genotype with high virulence to murine hosts (2017)
Journal Article
Gao, J., Xie, Y., Xu, Z., Chen, H., Hide, G., Yang, T., …Lun, Z. (2017). Genetic analyses of Chinese isolates of Toxoplasma gondii reveal a new genotype with high virulence to murine hosts. Veterinary Parasitology, 241, 52-60. https://doi.org/10.1016/j.vetpar.2017.05.007

A great deal of evidence demonstrates that a strongly clonal population structure of Toxoplasma gondii strains exists in humans and animals in North America and Europe, while the strains from South America are genetically separate and more diverse. P... Read More about Genetic analyses of Chinese isolates of Toxoplasma gondii reveal a new genotype with high virulence to murine hosts.

Mapping the ionic fingerprints of molecular monolayers (2017)
Journal Article
Lehr, J., Weeks, J., Santos, A., Feliciano, G., Nicholson, M., Davis, J., & Bueno, P. (2017). Mapping the ionic fingerprints of molecular monolayers. Physical Chemistry Chemical Physics, 19(23), 15098-15109. https://doi.org/10.1039/c7cp01500c

We have previously proposed, and experimentally resolved, an ionic charge relaxation model for redox inactive self-assembled monolayers (SAMs) on metallic electrodes in contact with a liquid electrolyte. Here we analyse, by capacitance spectroscopy,... Read More about Mapping the ionic fingerprints of molecular monolayers.

Modulation of antimalarial activity at a putative bisquinoline receptor in vivo using fluorinated bisquinolines (2017)
Journal Article
Fielding, A., Lukinović, V., Evans, P., Alizadeh-Shekalgourabi, S., Bisby, R., Drew, M., …Ismail, F. (2017). Modulation of antimalarial activity at a putative bisquinoline receptor in vivo using fluorinated bisquinolines. Chemistry - A European Journal, 23(28), 6811-6828. https://doi.org/10.1002/chem.201605099

Antimalarials can interact with heme covalently, by π⋅⋅⋅π interactions or by hydrogen bonding. Consequently, the prototropy of 4‐aminoquinolines and quinoline methanols was investigated by using quantum mechanics. Calculations showed mefloquine proto... Read More about Modulation of antimalarial activity at a putative bisquinoline receptor in vivo using fluorinated bisquinolines.