Modulation of vascular reactivity by perivascular adipose tissue (PVAT) (2018)
Journal Article
Agabiti Rosei, C., Paini, A., De Ciuceis, C., Withers, S., Greenstein, A., Heagerty, A., & Rizzoni, D. (2018). Modulation of vascular reactivity by perivascular adipose tissue (PVAT). Current Hypertension Reports, 20(44), https://doi.org/10.1007/s11906-018-0835-5

Purpose of Review: In this review we discuss the role of perivascular adipose tissue (PVAT) in the modulation of vascular contractility and arterial pressure, focusing on the role of the renin-angiotensin-aldosterone system and oxidative stress/infla... Read More about Modulation of vascular reactivity by perivascular adipose tissue (PVAT).

Echinococcus granulosus cyst fluid enhances epithelial - mesenchymal transition (2018)
Journal Article
Mohammed, A., Allen, J., & Rogan, M. (2018). Echinococcus granulosus cyst fluid enhances epithelial - mesenchymal transition. Parasite Immunology, 40(6), e12533. https://doi.org/10.1111/pim.12533

Aims Cystic Echinococcosis is characterised by fluid filled hydatid cysts in the liver and lungs. The cysts are surrounded by a host fibrous layer (the pericyst) which acts to isolate the parasite from surrounding tissues. Previous studies in liver... Read More about Echinococcus granulosus cyst fluid enhances epithelial - mesenchymal transition.

Personalizing hypertension treatment? (2018)
Journal Article
Withers, S., Saxton, S., & Heagerty, A. (2018). Personalizing hypertension treatment?. Hypertension, 71(6), 1028-1029. https://doi.org/10.1161/HYPERTENSIONAHA.118.11107

Editorial.

Bergamot natural products eradicate cancer stem cells (CSCs) by targeting mevalonate, Rho-GDI-signalling and mitochondrial metabolism (2018)
Journal Article
Fiorillo, M., Peiris-Pagès, M., Sanchez-Alvarez, R., Bartella, L., Di Donna, L., Dolce, V., …Lisanti, M. (2018). Bergamot natural products eradicate cancer stem cells (CSCs) by targeting mevalonate, Rho-GDI-signalling and mitochondrial metabolism. BBA - Bioenergetics, 1859(9), 984-996. https://doi.org/10.1016/j.bbabio.2018.03.018

Here, we show that a 2:1 mixture of Brutieridin and Melitidin, termed “BMF”, has a statin-like properties, which blocks the action of the rate-limiting enzyme for mevalonate biosynthesis, namely HMGR (3-hydroxy-3-methylglutaryl- CoA-reductase). Mor... Read More about Bergamot natural products eradicate cancer stem cells (CSCs) by targeting mevalonate, Rho-GDI-signalling and mitochondrial metabolism.

Circulating microRNAs predict survival of patients with tumors of glial origin (2018)
Journal Article
Drusco, A., Fadda, P., Nigita, G., Fassan, M., Bottoni, A., Gardiman, M., …Croce, C. (2018). Circulating microRNAs predict survival of patients with tumors of glial origin. EBioMedicine, 30, 105-112. https://doi.org/10.1016/j.ebiom.2018.03.022

The World Health Organization has recently introduced molecular prognostic-diagnostic biomarkers in the classification of Central Nervous System (CNS) tumors. In order to characterize subclasses of tumors that cannot find a precise location in the cu... Read More about Circulating microRNAs predict survival of patients with tumors of glial origin.

Loss of miR-204 expression is a key event in melanoma (2018)
Journal Article
Galasso, M., Morrison, C., Minotti, L., Corra, F., Zerbinati, C., Agnoletto, C., …Volinia, S. (2018). Loss of miR-204 expression is a key event in melanoma. Molecular Cancer, 17(71), https://doi.org/10.1186/s12943-018-0819-8

Cutaneous melanoma (CM) is a malignancy with increasing occurrence. Its microRNA repertoire has been defined in a number studies, leading to candidates for biological and clinical relevance: miR-200a/b/c, miR-203, miR-205, miR-204, miR-211, miR-23b a... Read More about Loss of miR-204 expression is a key event in melanoma.

Exploiting mitochondrial targeting signal(s), TPP and bis-TPP, for eradicating cancer stem cells (CSCs) (2018)
Journal Article
Ozsvari, B., Sotgia, F., & Lisanti, M. (2018). Exploiting mitochondrial targeting signal(s), TPP and bis-TPP, for eradicating cancer stem cells (CSCs). Aging, 10(2), 229-240. https://doi.org/10.18632/aging.101384

Tri-phenyl-phosphonium (TPP) is a non-toxic chemical moiety that functionally behaves as a mitochondrial targeting signal (MTS) in living cells. Here, we explored the hypothesis that TPP-related compounds could be utilized to inhibit mitochondria in... Read More about Exploiting mitochondrial targeting signal(s), TPP and bis-TPP, for eradicating cancer stem cells (CSCs).

Antiproliferative activity of glycosaminoglycan-like polysaccharides derived from marine molluscs (2018)
Journal Article
polysaccharides derived from marine molluscs. Marine Drugs, 16(2), 63. https://doi.org/10.3390/md16020063

Despite the increasing availability of new classes of cancer treatment, such as immuneand targeted therapies, there remains a need for the development of new antiproliferative/cytotoxic drugs with improved pharmacological profiles that can also ove... Read More about Antiproliferative activity of glycosaminoglycan-like polysaccharides derived from marine molluscs.

Silver nanoparticles impair retinoic acid-inducible gene I mediated mitochondrial anti-viral immunity by blocking the autophagic flux in lung epithelial cells (2018)
Journal Article
Villeret, B., Dieu, A., Straube, M., Solhonne, B., Miklavc, P., Hamadi, S., …Garcia-Verdugo, I. (2018). Silver nanoparticles impair retinoic acid-inducible gene I mediated mitochondrial anti-viral immunity by blocking the autophagic flux in lung epithelial cells. ACS nano, 12(2), 1188-1202. https://doi.org/10.1021/acsnano.7b06934

Silver nanoparticles (AgNPs) are microbicidal agents which could be potentially used as alternative to antivirals to treat human infectious diseases, especially Influenza virus infection where antivirals have generally proven unsuccessful. However, c... Read More about Silver nanoparticles impair retinoic acid-inducible gene I mediated mitochondrial anti-viral immunity by blocking the autophagic flux in lung epithelial cells.

Mitochondrial fission as a driver of stemness in tumor cells : mDIVI1 inhibits mitochondrial function, cell migration and cancer stem cell (CSC) signalling (2018)
Journal Article
Peiris-Pagès, M., Bonuccelli, G., Sotgia, F., & Lisanti, M. (2018). Mitochondrial fission as a driver of stemness in tumor cells : mDIVI1 inhibits mitochondrial function, cell migration and cancer stem cell (CSC) signalling. Oncotarget, 9(17), 13254-13275. https://doi.org/10.18632/oncotarget.24285

Mitochondria are dynamic organelles frequently undergoing fission and fusion events to maintain their integrity, bioenergetics and spatial distribution, which is fundamental to the processes of cell survival. Disruption in mitochondrial dynamics play... Read More about Mitochondrial fission as a driver of stemness in tumor cells : mDIVI1 inhibits mitochondrial function, cell migration and cancer stem cell (CSC) signalling.

Ram locus is a key regulator to trigger multidrug resistance in Enterobacter aerogenes (2018)
Journal Article
Molitor, A., James, C., Fanning, S., Pages, J., & Davin-Regli, A. (2018). Ram locus is a key regulator to trigger multidrug resistance in Enterobacter aerogenes. Journal of Medical Microbiology, 67(2), 148-159. https://doi.org/10.1099/jmm.0.000667

Purpose: Several genetic regulators belonging to AraC family are involved in the emergence of MDR isolates of E. aerogenes due to alterations in membrane permeability. Compared with the genetic regulator Mar, RamA may be more relevant towards the eme... Read More about Ram locus is a key regulator to trigger multidrug resistance in Enterobacter aerogenes.