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Synthesis and Characterisation of Metal Organic Frameworks for Use as Drug Delivery Systems in Neuroblastoma Therapy (2024)
Thesis
Nduka, I. O. (2024). Synthesis and Characterisation of Metal Organic Frameworks for Use as Drug Delivery Systems in Neuroblastoma Therapy. (Thesis). University of Salford

Gliotoxin, a secondary metabolite isolated from the fungi, Aspergillus fumigatus has shown cytotoxic activity against neuroblastoma, a type of cancer accounting for 15% of all childhood cancer-related deaths. But as with all other chemotherapeutic... Read More about Synthesis and Characterisation of Metal Organic Frameworks for Use as Drug Delivery Systems in Neuroblastoma Therapy.

Investigating small extracellular vesicle miRNA as biomarkers for Alzheimer’s disease (2023)
Thesis
Aarons, T. (2023). Investigating small extracellular vesicle miRNA as biomarkers for Alzheimer’s disease. (Thesis). University of Salford

Alzheimer’s disease (AD) is the leading cause of dementia, a syndrome impacting over 900,000 people in the UK alone. There are currently no disease modifying treatments for AD, which is largely attributable to the heterogenous basis of the disease wh... Read More about Investigating small extracellular vesicle miRNA as biomarkers for Alzheimer’s disease.

Characterisation of inflammatory mediators in ischaemic heart disease (2022)
Thesis
Borun, A. Characterisation of inflammatory mediators in ischaemic heart disease. (Dissertation). University of Salford

Coronary artery disease (CAD) is one of the most common causes of death in general population. In the UK it accounts for 64000 deaths annually and there are currently 2.3 million people living with CAD. Persistent inflammation of myocardium is believ... Read More about Characterisation of inflammatory mediators in ischaemic heart disease.

Investigating senescence and senescence-escape in cancer cells (2022)
Thesis
Toth, F. (2022). Investigating senescence and senescence-escape in cancer cells. (Thesis). University of Salford

Despite the general concept that therapy-induced senescence (TIS) has a tumour-suppressive role, the presence of senescent tumour cells and the ability of cancer cells to escape from senescence could potentially lead to therapy resistance and tumour... Read More about Investigating senescence and senescence-escape in cancer cells.

Identification and characterisation of lignin degrading bacteria and enzymes from larval guts of the African Palm Weevil (Rhynchophorus phoenicis) (2022)
Thesis
larval guts of the African Palm Weevil (Rhynchophorus phoenicis). (Thesis). University of Salford

As developing economies continue to grow, the world’s demand for energy which currently stands at 84MB (million barrels oil) per day is projected to rise to 116 MB per day by the year 2030. The need to meet this continuous rise in demand for energy w... Read More about Identification and characterisation of lignin degrading bacteria and enzymes from larval guts of the African Palm Weevil (Rhynchophorus phoenicis).

Evaluation of small extracellular vesicular microRNAs as biomarkers for exposure of nicotine and E-liquids on human lung cells (2022)
Thesis
for exposure of nicotine and E-liquids on human lung cells. (Thesis). University of Salford

Nicotine intake and E-Cigarette or vaping product use-associated lung injury (EVALI) can cause pulmonary disease with damaging health effects. In this study, we explored miRNAs from small extracellular vesicles (sEVs) for nicotine and E-liquid-associ... Read More about Evaluation of small extracellular vesicular microRNAs as biomarkers for exposure of nicotine and E-liquids on human lung cells.

Investigation of de-novo copy number variants in patients with Autism Spectrum Disorder in Vietnam (2021)
Thesis
Bui, H. Investigation of de-novo copy number variants in patients with Autism Spectrum Disorder in Vietnam. (Thesis). University of Salford

Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a prevalence of approximately 1% children worldwide. ASD is characterized by deficits in social communication and interaction and the presence of restricted interests and repetitive... Read More about Investigation of de-novo copy number variants in patients with Autism Spectrum Disorder in Vietnam.

The chemotherapeutic potential of Boswellia carterii oleoresins (2021)
Thesis
Jones, M. The chemotherapeutic potential of Boswellia carterii oleoresins. (Thesis). University of Salford

Cancer is a leading cause of death worldwide. Though effective treatments are available and reduce mortality, issues such as debilitating side-effects and drug resistance necessitate a need to develop alternatives. Natural products are a key and dive... Read More about The chemotherapeutic potential of Boswellia carterii oleoresins.

The relationship between the infection of Toxoplasma gondii and Alzheimer’s disease (2021)
Thesis
Alawfi, B. (2021). The relationship between the infection of Toxoplasma gondii and Alzheimer’s disease. (Thesis). University of Salford

Toxoplasma gondii is a zoonotic parasite that commonly causes infections in a variety of warm-blooded animals including humans. This parasite causes a disease referred to as toxoplasmosis. T. gondii infections are known to have a significant impact o... Read More about The relationship between the infection of Toxoplasma gondii and Alzheimer’s disease.

Exploring potential inhibitors of the HGF-Met signalling pathway as a prospective treatment for paediatric medulloblastoma (2021)
Thesis
Hoyles, N. Exploring potential inhibitors of the HGF-Met signalling pathway as a prospective treatment for paediatric medulloblastoma. (Dissertation). University of Salford

Understanding the function of the HGF-Met signalling axis could present opportunities for new therapeutic treatments for cancer patients. The brain tumour Medulloblastoma is the leading cause of cancer-related death in children and infants meaning re... Read More about Exploring potential inhibitors of the HGF-Met signalling pathway as a prospective treatment for paediatric medulloblastoma.

Synthesis and Evaluation of Benzoyl containing compounds as potential anti-cancer agents (2021)
Thesis
Ahmed, S. M. Synthesis and Evaluation of Benzoyl containing compounds as potential anti-cancer agents. (Thesis). University of Salford

Seen as one of the major causes of death worldwide, Cancer requires the development of effective treatments to combat the disease. However, pharmaceutical companies are faced by the challenge of finding and developing a suitable compound that can ove... Read More about Synthesis and Evaluation of Benzoyl containing compounds as potential anti-cancer agents.

Exploring the influence of adipokines on neuronal function in Alzheimer’s disease (2021)
Thesis
Tomar, N. Exploring the influence of adipokines on neuronal function in Alzheimer’s disease. (Thesis). University of Salford

Alzheimer’s disease (AD) is one of the major causes of dementia. Alzheimer’s disease is an irreversible, slow neurodegenerative disease leading to memory and language impairment and amyloid-β plaques and intraneuronal neurofibrillary tangles are the... Read More about Exploring the influence of adipokines on neuronal function in Alzheimer’s disease.

An investigation into Toxoplasma gondii infection and the expression of Arginase-1 and iNOS in human lung tissue (2021)
Thesis
Soothill, H. An investigation into Toxoplasma gondii infection and the expression of Arginase-1 and iNOS in human lung tissue. (Dissertation). University of Salford

This study aimed to investigate the relationship between Toxoplasma gondii infection and the expression of the immune modulating proteins Arginase-1 and iNOS in human lung biopsy samples. Previously, a 100% toxoplasmosis infection rate was found in 7... Read More about An investigation into Toxoplasma gondii infection and the expression of Arginase-1 and iNOS in human lung tissue.

Investigating Interleukin – 8 and TGF Beta as early biomarkers predicting poor clinical outcome in major trauma (2021)
Thesis
Abbood, L. Investigating Interleukin – 8 and TGF Beta as early biomarkers predicting poor clinical outcome in major trauma. (Dissertation). University of Salford

Trauma is a leading cause of death and disability. Globally, traumatic injury is the main cause of death under the age of 45. Recent studies from the UK report a demographic change in major trauma. The most common mechanism of traumatic injury is fal... Read More about Investigating Interleukin – 8 and TGF Beta as early biomarkers predicting poor clinical outcome in major trauma.

Investigation into the genetic variation of Toll-Like Receptor 9 in cattle using both Sanger and next-generation sequencing from FTA-Cards (2020)
Thesis
Alqurashi, A. Investigation into the genetic variation of Toll-Like Receptor 9 in cattle using both Sanger and next-generation sequencing from FTA-Cards. (Thesis). University of Salford

The susceptibility or resistance to infectious diseases depends on the host immune response. The genetic variation of immune-relevant genes such as Toll-Like Receptor (TLR) genes is associated with susceptibility or resistance to the pathogen. In thi... Read More about Investigation into the genetic variation of Toll-Like Receptor 9 in cattle using both Sanger and next-generation sequencing from FTA-Cards.

Synthesis and evaluation of benzoyl containing compounds as potential anti-cancer agents (2020)
Thesis
Ahmed, S. Synthesis and evaluation of benzoyl containing compounds as potential anti-cancer agents. (Dissertation). University of Salford

Seen as one of the major causes of death worldwide, Cancer requires the development of effective treatments in order to combat the disease. However, pharmaceutical companies are faced by the challenge of finding and developing a suitable compound tha... Read More about Synthesis and evaluation of benzoyl containing compounds as potential anti-cancer agents.

Investigating the relationship between lung cancer and the infection with the parasite Toxoplasma gondii (2020)
Thesis
Tarabulsi, M. Investigating the relationship between lung cancer and the infection with the parasite Toxoplasma gondii. (Thesis). University of Salford

Toxoplasma gondii is an obligate intracellular organism that has a worldwide distribution and is highly prevalent among animals and humans. Although usually asymptomatic, it can cause serious diseases in immunocompromised individuals such as pneumoni... Read More about Investigating the relationship between lung cancer and the infection with the parasite Toxoplasma gondii.

In vitro screening of Trametes versicolor and Acacia nilotica derivatives for antimalarial efficacy (2020)
Thesis
Dillon, M. In vitro screening of Trametes versicolor and Acacia nilotica derivatives for antimalarial efficacy. (Dissertation). University of Salford

Of the plethora of parasitic diseases that afflict mankind, malaria remains the most prevalent. The disease has caused severe global health problems, putting 3.2 billion people at risk of developing the Plasmodium infection. With current front-line t... Read More about In vitro screening of Trametes versicolor and Acacia nilotica derivatives for antimalarial efficacy.