Synthesis and evaluation of benzoyl containing compounds as potential anti-cancer agents

Ahmed, S

Abstract

Seen as one of the major causes of death worldwide, Cancer requires the development of effective treatments in order to combat the disease. However, pharmaceutical companies are faced by the challenge of finding and developing a suitable compound that can override the barriers of the human body and operate effectively in its pharmacological properties.
The research conducted in this investigation looks at a naturally occurring compound, Dibenzoyl methane (DBM), its derivatives, and a few additional synthesised compounds with similar chemical properties and their unique activities demonstrated. DBM and its derivatives are classified as β-diketones and were synthesised using two different chemical schemes; the Baker-Venkataraman rearrangement and the Claisen acylation.
In comparison to this, a recently discovered synthetic class of compounds, N-benzoyl-N’-phenylurea and derivatives were also studied during the period of this investigation. The cytotoxicity of the drug candidates was determined on live mammalian cell lines including HepG2, HeLa and HCT 116 amongst a few supplementary cell lines using the MTT assay. In addition since the final stage of a potential drug compound is associated with the mechanisms of a human body, pharmacological factors such as stability within plasma and metabolic stability were measured. These are responsible for measuring the degradation of the compound over time and looking at the ability of the liver to remove the administered drug respectively. The data was collected and appropriately converted to be plotted and analysed to assess the efficacy of the drug candidates as potential anti-cancer agents

Citation

Ahmed, S. Synthesis and evaluation of benzoyl containing compounds as potential anti-cancer agents. (Dissertation). University of Salford

• Thesis Type: Dissertation
• Deposit Date: Dec 17, 2020
• Publicly Available Date: Dec 17, 2020
• Award Date: Nov 23, 2020