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Facile synthesis and biological evaluation of chrysin derivatives

Omonga, NF; Zia, Z; Ghanbour, HA; Ragazzon-Smith, AH; Foster, HA; Hadfield, JA; Ragazzon, PA

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Authors

NF Omonga

Z Zia

HA Ghanbour

AH Ragazzon-Smith

HA Foster

JA Hadfield

PA Ragazzon



Abstract

In this paper, novel synthetic methods, including microwave O-alkylation, were used to produce several chrysin derivatives. These compounds were purified, characterised and tested on different cell lines and bacterial strains. From this family, 7-(2,4-dinitrophenoxy)-5-hydroxy-3-phenyl-4H-chromen-4-one (C3) was shown to be extremely active on bacterial strains methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae as well as having anticancer activity on a range of cancer cell lines with IC50 values less than 30 µM. Chrysin has been known for their anticancer and antimicrobial properties, and this study not only corroborates this but also shows that it is possible to synthesise new improved derivatives with therapeutic possibilities.

Citation

Omonga, N., Zia, Z., Ghanbour, H., Ragazzon-Smith, A., Foster, H., Hadfield, J., & Ragazzon, P. (2021). Facile synthesis and biological evaluation of chrysin derivatives. Journal of Chemical Research, 45(11-12), 1083-1092. https://doi.org/10.1177/17475198211057467

Journal Article Type Article
Online Publication Date Nov 29, 2021
Publication Date Nov 29, 2021
Deposit Date Dec 6, 2021
Publicly Available Date Dec 6, 2021
Journal Journal of Chemical Research
Print ISSN 1747-5198
Electronic ISSN 2047-6507
Publisher SAGE Publications
Volume 45
Issue 11-12
Pages 1083-1092
DOI https://doi.org/10.1177/17475198211057467
Publisher URL https://doi.org/10.1177/17475198211057467
Related Public URLs https://journals.sagepub.com/home/chl
Additional Information Funders : Nigerian Government;University of Salford
Projects : The synthesis, isolation and evaluation of novel anticancer and antibacterial therapeutics derived from natural products

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