Targeting cancer stem cell propagation with palbociclib, a CDK4/6 inhibitor: Telomerase drives tumor cell heterogeneity (2016)
Journal Article
Bonuccelli, G., Peires-Pages, M., Ozsvari, B., Martinez- Outschoorn, U., Sotgia, F., & Lisanti, M. (2017). Targeting cancer stem cell propagation with palbociclib, a CDK4/6 inhibitor: Telomerase drives tumor cell heterogeneity. Oncotarget, 8(6), 9868-9884. https://doi.org/10.18632/oncotarget.14196

In this report, we systematically examined the role of telomerase activity in lung and ovarian cancer stem cell (CSC) propagation. For this purpose, we indirectly gauged telomerase activity, by linking the hTERT-promoter to eGFP. Using lung (A549)... Read More about Targeting cancer stem cell propagation with palbociclib, a CDK4/6 inhibitor: Telomerase drives tumor cell heterogeneity.

Toxicological and analytical assessment of e-cigarette refill components on airway epithelia (2016)
Journal Article
Singh, J., Luquet, E., Smith, D., Potgieter, H., & Ragazzon, P. (2016). Toxicological and analytical assessment of e-cigarette refill components on airway epithelia. Science Progress, 99(4), 351-398. https://doi.org/10.3184/003685016X14773090197706

There are over 2.6 million users of e-cigarettes in the United Kingdom alone as they have been promoted as safer alternative to traditional cigarettes. The addition of flavours and aromas has also proven to be popular with younger generations. In thi... Read More about Toxicological and analytical assessment of e-cigarette refill components on airway epithelia.

Dibenzoyl-methane derivatives as potential and exciting new therapy for the treatment of childhood bone cancer (2016)
Journal Article
Almelah, E., Smith, D., McGown, A., Aziz, A., Potgieter, H., & Ragazzon, P. (2016). Dibenzoyl-methane derivatives as potential and exciting new therapy for the treatment of childhood bone cancer. Anticancer Research, 36(11), 6043-6050. https://doi.org/10.21873/anticanres.11193

Abstract. Childhood bone cancer though rare, has very limited treatment choices, with poor survival rates and often involving amputation. We have developed a novel molecule, 2', 4'-dihydroxy-dithion-dibenzoyl-methane and tested it on hepatic, colon,... Read More about Dibenzoyl-methane derivatives as potential and exciting new therapy for the treatment of childhood bone cancer.

Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank–Starling response (2016)
Journal Article
Scotcher, J., Prysyazhna, O., Boguslavskyi, A., Kistamas, K., Hadgraft, N., Martin, E., …Eaton, P. (2016). Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank–Starling response. Nature communications, 7, 13187. https://doi.org/10.1038/ncomms13187

The Frank–Starling mechanism allows the amount of blood entering the heart from the veins to be precisely matched with the amount pumped out to the arterial circulation. As the heart fills with blood during diastole, the myocardium is stretched and o... Read More about Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank–Starling response.

High frequency detection of Toxoplasma gondii DNA in human neonatal tissue from Libya (2016)
Journal Article
Haq, S., Abushahma, M., Gerwash, O., Hughes, J., Wright, E., Elmahaishi, M., …Hide, G. (2016). High frequency detection of Toxoplasma gondii DNA in human neonatal tissue from Libya. Transactions of The Royal Society of Tropical Medicine and Hygiene, 110(9), 551-557. https://doi.org/10.1093/trstmh/trw064

Background: Toxoplasma gondii is a parasite that causes significant disease in humans. Toxoplasmosis is normally asymptomatic, unless associated with congenital transmission, or in immunocompromised people. Congenital transmission generally occurs... Read More about High frequency detection of Toxoplasma gondii DNA in human neonatal tissue from Libya.

Does hydatid cyst fluid from Echinococcus granulosus cysts have any effect on cells involved in fibrosis in cystic echinococcosis? (2016)
Journal Article
Mohammed, A., Allen, J., & Rogan, M. (2016). Does hydatid cyst fluid from Echinococcus granulosus cysts have any effect on cells involved in fibrosis in cystic echinococcosis?. Journal of Parasitology and Bacteriology, 7(5), https://doi.org/10.4172/2155-9597.C1.023

Cystic echinococcosis is characterized by the presence of slow growing hydatid cysts, usually in the liver or lungs. Survival of the parasite is based on an interaction of the host immune system and a range of parasite immune-evasive strategies. Fibr... Read More about Does hydatid cyst fluid from Echinococcus granulosus cysts have any effect on cells involved in fibrosis in cystic echinococcosis?.

Human brain harbors single nucleotide somatic variations in functionally relevant genes possibly mediated by oxidative stress (2016)
Journal Article
Sharma, A., Ansan, A., Kumari, R., Pandey, R., Rehman, R., Mehani, B., …Mukhopadhyay, A. (2017). Human brain harbors single nucleotide somatic variations in functionally relevant genes possibly mediated by oxidative stress. F1000Research, 5, 2520. https://doi.org/10.12688/f1000research.9495.3

Somatic variation in DNA can cause cells to deviate from the preordained genomic path in both disease and healthy conditions. Here, using exome sequencing of paired tissue samples, we show that the normal human brain harbors somatic single base va... Read More about Human brain harbors single nucleotide somatic variations in functionally relevant genes possibly mediated by oxidative stress.

Trehalose, an easy, safe and efficient cryoprotectant for the parasitic protozoan Trypanosoma brucei (2016)
Journal Article
Wen, Y., Su, B., Lyu, S., Hide, G., Lun, Z., & Lai, D. (2016). Trehalose, an easy, safe and efficient cryoprotectant for the parasitic protozoan Trypanosoma brucei. Acta tropica, 164, 297-302. https://doi.org/10.1016/j.actatropica.2016.09.024

Trehalose, a non-permeating cryoprotective agent (CPA), has been documented as less toxic and highly efficient at cryopreserving different kinds of cells or organisms. In the present study, trehalose was evaluated for its application in cryopreservat... Read More about Trehalose, an easy, safe and efficient cryoprotectant for the parasitic protozoan Trypanosoma brucei.

“Omics”-Informed drug and biomarker discovery : opportunities, challenges and future perspectives (2016)
Journal Article
Matthews, H., Hanison, J., & Nirmalan, N. (2016). “Omics”-Informed drug and biomarker discovery : opportunities, challenges and future perspectives. Proteomes, 4(3), 28. https://doi.org/10.3390/proteomes4030028

The pharmaceutical industry faces unsustainable program failure despite significant increases in investment. Dwindling discovery pipelines, rapidly expanding R&D budgets and increasing regulatory control, predict significant gaps in the future drug m... Read More about “Omics”-Informed drug and biomarker discovery : opportunities, challenges and future perspectives.

The differential hormonal milieu of morning versus evening, may have an impact on muscle hypertrophic potential (2016)
Journal Article
Burley, S., Whittingham-Dowd, J., Allen, J., Grosset, J., & Onambele-Pearson, G. (2016). The differential hormonal milieu of morning versus evening, may have an impact on muscle hypertrophic potential. PLoS ONE, 11(9), e0161500. https://doi.org/10.1371/journal.pone.0161500

Substantial gains in muscle strength and hypertrophy are clearly associated with the routine performance of resistance training. What is less evident is the optimal timing of the resistance training stimulus to elicit these significant functional and... Read More about The differential hormonal milieu of morning versus evening, may have an impact on muscle hypertrophic potential.

Inhibition of Bcl-xL sensitizes cells to mitotic blockers, but not mitotic drivers (2016)
Journal Article
Bennett, A., Sloss, O., Topham, C., Nelson, L., Tighe, A., & Taylor, S. (2016). Inhibition of Bcl-xL sensitizes cells to mitotic blockers, but not mitotic drivers. Open Biology, 6(8), https://doi.org/10.1098/rsob.160134

Cell fate in response to an aberrant mitosis is governed by two competing networks: the spindle assembly checkpoint (SAC) and the intrinsic apoptosis pathway. The mechanistic interplay between these two networks is obscured by functional redundancy a... Read More about Inhibition of Bcl-xL sensitizes cells to mitotic blockers, but not mitotic drivers.

Oxidative stress and breast cancer biomarkers : the case of the cytochrome P450 2E1 (2016)
Journal Article
Singh, S., Rajendran, R., Kuroda, K., Isogai, E., Krstic-Demonacos, M., & Demonacos, C. (2016). Oxidative stress and breast cancer biomarkers : the case of the cytochrome P450 2E1. Journal of Cancer Metastasis and Treatment, 2, 268-276. https://doi.org/10.20517/2394-4722.2016.42

Aim: The aim of the study is to investigate the impact of the cytochrome P450 2E1, which is the most efficient CYP450 family member in generating reactive oxygen species (ROS), on cellular energy metabolism of breast cancer cells and therefore the... Read More about Oxidative stress and breast cancer biomarkers : the case of the cytochrome P450 2E1.

Mobile, wearable and ingestible health technologies : towards a critical research agenda (2016)
Journal Article
Rich, E., & Miah, A. (2017). Mobile, wearable and ingestible health technologies : towards a critical research agenda. Health Sociology Review, 26(1), 84-97. https://doi.org/10.1080/14461242.2016.1211486

In this article, we review critical research on mobile and wearable health technologies focused on the promotion of ‘healthy lifestyles’. We begin by discussing key governmental and policy interests which indicate a shift towards greater digital inte... Read More about Mobile, wearable and ingestible health technologies : towards a critical research agenda.

A new standard for assessing asbestos exposure and its consequences? (2016)
Journal Article
Mutti, L. (2016). A new standard for assessing asbestos exposure and its consequences?. Occupational and Environmental Medicine, 73(10), 709-710. https://doi.org/10.1136/oemed-2016-103693

Comment on the original article: Gilham C, Rake C, Burdett G, et al. Pleural mesothelioma and lung cancer risks in relation to occupational history and asbestos lung burden. Occup Environ Med 2015; doi: 10.1136/oemed-2015-103074.

Different types of small RNAs in protozoa (2016)
Book Chapter
Zheng, L., Liao, J., Wen, Y., Hide, G., Qu, L., & Lun, Z. (2016). Different types of small RNAs in protozoa. In A. Leitao, & F. Enguita (Eds.), Non-coding RNAs and inter-kingdom communication (177-196). Springer International Publishing. https://doi.org/10.1007/978-3-319-39496-1_11

The origin and evolution of small RNA molecules is a long-standing mystery. The protozoa represent the earliest eukaryotes and encompass rich diverse genetic resources. However, there are many contradictions and disputes prevalent in studies on proto... Read More about Different types of small RNAs in protozoa.

Expanding the scope of the Babler-Daubin oxidation : 1,3-oxidative transposition of secondary allylic alcohols (2016)
Journal Article
Killoran, P., Rossington, S., Wilkinson, J., & Hadfield, J. (2016). Expanding the scope of the Babler-Daubin oxidation : 1,3-oxidative transposition of secondary allylic alcohols. Tetrahedron Letters, 57(35), 3954-3957. https://doi.org/10.1016/j.tetlet.2016.07.076

We report the catalytic chromium-mediated oxidation of secondary allylic alcohols to give α,β-unsaturated aldehydes with exclusive (E)-stereoselectivity. This facile procedure employs catalytic PCC (5 mol%) and periodic acid (H5IO6) as a co-oxidant.... Read More about Expanding the scope of the Babler-Daubin oxidation : 1,3-oxidative transposition of secondary allylic alcohols.

MiR-9 and miR-200 regulate PDGFRβ-mediated endothelial differentiation of tumor cells in triple negative breast cancer (2016)
Journal Article
D'Ippolito, E., Plantamura, I., Bongiovanni, L., Casalini, P., Baroni, S., Piovan, C., …Iorio, M. (2016). MiR-9 and miR-200 regulate PDGFRβ-mediated endothelial differentiation of tumor cells in triple negative breast cancer. Cancer Research, 76(14), https://doi.org/10.1158/0008-5472.CAN-16-0140

Organization of cancer cells into endothelial-like cell lined structures to support neovascularization and fuel solid tumors is a hallmark of progression and poor outcome. In triple negative breast cancer (TNBC), PDGFRβ has been identified as a key p... Read More about MiR-9 and miR-200 regulate PDGFRβ-mediated endothelial differentiation of tumor cells in triple negative breast cancer.

Detection and analysis of spin trapped radical adducts by using alpha-phenyl-tert-butyl nitrone (PBN) derivatives and GC/MS (2016)
Thesis
Mishra, S. Detection and analysis of spin trapped radical adducts by using alpha-phenyl-tert-butyl nitrone (PBN) derivatives and GC/MS. (Thesis). University of Salford

Bedaquiline, an FDA-approved antibiotic, inhibits mitochondrial function and potently blocks the proliferative expansion of stem-like cancer cells (CSCs) (2016)
Journal Article
Fiorillo, M., Lamb, R., Tanowitz, H., Cappello, A., Martinez‐Outschoorn, U., Sotgia, F., & Lisanti, M. (2016). Bedaquiline, an FDA-approved antibiotic, inhibits mitochondrial function and potently blocks the proliferative expansion of stem-like cancer cells (CSCs). Aging, 8(8), 1593-1607. https://doi.org/10.18632/aging.100983

Bedaquiline (a.k.a., Sirturo) is an anti‐microbial agent, which is approved by the FDA for the treatment of multi‐drug resistant pulmonary tuberculosis (TB). Bedaquiline is a first‐in‐class diaryl‐quinoline compound, that mechanistically inhibits the... Read More about Bedaquiline, an FDA-approved antibiotic, inhibits mitochondrial function and potently blocks the proliferative expansion of stem-like cancer cells (CSCs).

Effect of monoglycerides and fatty acids on a ceramide bilayer (2016)
Journal Article
ceramide bilayer. Physical Chemistry Chemical Physics, 18, 17446 -17460. https://doi.org/10.1039/c6cp01238h

Monoglycerides and unsaturated fatty acids, naturally present in trace amounts in the stratum corneum (top layer of skin) lipid matrix, are commonly used in pharmaceutical, cosmetic and health care formulations. However, a detailed molecular understa... Read More about Effect of monoglycerides and fatty acids on a ceramide bilayer.