Circular and linear : a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells (2020)
Journal Article
Al-Sudani, B., Ragazzon-Smith, A., Aziz, A., Alansari, R., Ferry, N., Krstic- Demonacos, M., & Ragazzon, P. (2020). Circular and linear : a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells. RSC Advances, 10(73), 45008-45018. https://doi.org/10.1039/D0RA07857C

It is a challenge to select the right target to treat conditions without affecting non-diseased cells. Cancer belongs to the top 10 causes of death in the world and it remains difficult to treat. Amongst cancer emerging targets, silent information re... Read More about Circular and linear : a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells.

Investigation into the genetic variation of Toll-Like Receptor 9 in cattle using both Sanger and next-generation sequencing from FTA-Cards (2020)
Thesis
Alqurashi, A. Investigation into the genetic variation of Toll-Like Receptor 9 in cattle using both Sanger and next-generation sequencing from FTA-Cards. (Thesis). University of Salford

The susceptibility or resistance to infectious diseases depends on the host immune response. The genetic variation of immune-relevant genes such as Toll-Like Receptor (TLR) genes is associated with susceptibility or resistance to the pathogen. In thi... Read More about Investigation into the genetic variation of Toll-Like Receptor 9 in cattle using both Sanger and next-generation sequencing from FTA-Cards.

Long-term trends in helminth infections of wood mice (Apodemus sylvaticus) from the vicinity of Malham Tarn in North Yorkshire, England (2020)
Journal Article
Behnke, J., Rogan, M., Craig, P., Jackson, J., & Hide, G. (2021). Long-term trends in helminth infections of wood mice (Apodemus sylvaticus) from the vicinity of Malham Tarn in North Yorkshire, England. Parasitology, 184(4), 451-463. https://doi.org/10.1017/S0031182020002243

Helminth infections in wood mice (n=483), trapped over a period of 26 years in the woods surrounding Malham Tarn in N. Yorkshire, were analysed. Although ten species of helminths were identified, the overall mean species richness was 1.01 species/m... Read More about Long-term trends in helminth infections of wood mice (Apodemus sylvaticus) from the vicinity of Malham Tarn in North Yorkshire, England.

Synthesis and evaluation of benzoyl containing compounds as potential anti-cancer agents (2020)
Thesis
Ahmed, S. Synthesis and evaluation of benzoyl containing compounds as potential anti-cancer agents. (Dissertation). University of Salford

Seen as one of the major causes of death worldwide, Cancer requires the development of effective treatments in order to combat the disease. However, pharmaceutical companies are faced by the challenge of finding and developing a suitable compound tha... Read More about Synthesis and evaluation of benzoyl containing compounds as potential anti-cancer agents.

RNA-seq analysis of colorectal tumor-infiltrating myeloid-derived suppressor cell subsets revealed gene signatures of poor prognosis (2020)
Journal Article
Saleh, R., Sasidharan Nair, V., Al-Dhaheri, M., Khawar, M., Abu Nada, M., Alajez, N., & Elkord, E. (2020). RNA-seq analysis of colorectal tumor-infiltrating myeloid-derived suppressor cell subsets revealed gene signatures of poor prognosis. Frontiers in Oncology, 10, 604906. https://doi.org/10.3389/fonc.2020.604906

Elevated levels of myeloid-derived suppressor cells (MDSCs), including polymorphonuclear MDSCs (PMN-MDSCs) and immature MDSCs (I-MDSCs), are usually associated with disease progression in cancer patients, including colorectal cancer (CRC). However, b... Read More about RNA-seq analysis of colorectal tumor-infiltrating myeloid-derived suppressor cell subsets revealed gene signatures of poor prognosis.

Targeting TIM-3 in solid tumors : innovations in the preclinical and translational realm and therapeutic potential (2020)
Journal Article
Saleh, R., Toor, S., & Elkord, E. (2020). Targeting TIM-3 in solid tumors : innovations in the preclinical and translational realm and therapeutic potential. Expert Opinion on Therapeutic Targets, 24(12), 1251-1262. https://doi.org/10.1080/14728222.2020.1841750

Introduction Immune checkpoint inhibitors (ICIs) have shown a great therapeutic efficacy in cancer patients. However, a significant proportion of cancer patients remain unresponsive or show limited response. T cell immunoglobulin and mucin-domain... Read More about Targeting TIM-3 in solid tumors : innovations in the preclinical and translational realm and therapeutic potential.

Detection and identification of ethanal-derived spin-trapped free radicals using headspace thermal desorption gas chromatography-mass spectrometry (TD-GC-MS) (2020)
Journal Article
Manzoor, K., Mishra, S., & Podmore, I. (2020). Detection and identification of ethanal-derived spin-trapped free radicals using headspace thermal desorption gas chromatography-mass spectrometry (TD-GC-MS). Free Radical Research, 54(10), 745-755. https://doi.org/10.1080/10715762.2020.1841183

In this study, we demonstrate a novel approach to the detection and identification of the products of spin-trapped free radicals. Hydroxyl free radicals were generated by Fenton-based chemistry in the presence of ethanal and the spin-trapping agent... Read More about Detection and identification of ethanal-derived spin-trapped free radicals using headspace thermal desorption gas chromatography-mass spectrometry (TD-GC-MS).

Protein disulfide isomerase A1 regulates breast cancer cell immunorecognition in a manner dependent on redox state (2020)
Journal Article
Alhammad, R., Khunchai, S., Tongmuang, N., Limjindaporn, T., Yenchitsomanus, P., Mutti, L., …Demonacos, C. (2020). Protein disulfide isomerase A1 regulates breast cancer cell immunorecognition in a manner dependent on redox state. Oncology Reports, 44(6), 2406-2418. https://doi.org/10.3892/or.2020.7816

Oxidoreductase protein disulphide isomerases (PDI) are involved in the regulation of a variety of biological processes including the modulation of endoplasmic reticulum (ER) stress, unfolded protein response (UPR), ER‑mitochondria communication and t... Read More about Protein disulfide isomerase A1 regulates breast cancer cell immunorecognition in a manner dependent on redox state.

An evaluation of sorter induced cell stress (SICS) on peripheral blood mononuclear cells (PBMCs) after different sort conditions - are your sorted cells getting SICS? (2020)
Journal Article
Pfister, G., Toor, S., Sasidharan Nair, V., & Elkord, E. (2020). An evaluation of sorter induced cell stress (SICS) on peripheral blood mononuclear cells (PBMCs) after different sort conditions - are your sorted cells getting SICS?. Journal of Immunological Methods, 487, 112902. https://doi.org/10.1016/j.jim.2020.112902

Flow cytometry and fluorescence-activated cell sorting have become invaluable tools to analyze and isolate specific cell populations in a wide range of biomedical research and clinical applications. In countless approaches worldwide, scientists are u... Read More about An evaluation of sorter induced cell stress (SICS) on peripheral blood mononuclear cells (PBMCs) after different sort conditions - are your sorted cells getting SICS?.

Interleukin-33 rescues perivascular adipose tissue anticontractile function in obesity (2020)
Journal Article
Saxton, S., Whitley, A., Potter, R., Withers, S., Grencis, R., & Heagerty, A. (2020). Interleukin-33 rescues perivascular adipose tissue anticontractile function in obesity. American journal of physiology. Heart and circulatory physiology, 319(6), H1387-H1397. https://doi.org/10.1152/ajpheart.00491.2020

Perivascular adipose tissue (PVAT) depots are metabolically active and play a major vasodilator role in healthy lean individuals. In obesity, they become inflamed and eosinophil-depleted and the anticontractile function is lost with the development o... Read More about Interleukin-33 rescues perivascular adipose tissue anticontractile function in obesity.

3D DESI-MS lipid imaging in a xenograft model of glioblastoma : a proof of principle (2020)
Journal Article
Henderson, F., Jones, E., Denbigh, J., Christie, L., Chapman, R., Hoyes, E., …McMahon, A. (2020). 3D DESI-MS lipid imaging in a xenograft model of glioblastoma : a proof of principle. Scientific reports, 10, 16512. https://doi.org/10.1038/s41598-020-73518-x

Desorption electrospray ionisation mass spectrometry (DESI-MS) can image hundreds of molecules in a 2D tissue section, making it an ideal tool for mapping tumour heterogeneity. Tumour lipid metabolism has gained increasing attention over the past dec... Read More about 3D DESI-MS lipid imaging in a xenograft model of glioblastoma : a proof of principle.

Living with Coronavirus (COVID-19) : a brief report (2020)
Journal Article
Khurshid, A., Ahmed, M., Aziz, A., & Amin, R. (2020). Living with Coronavirus (COVID-19) : a brief report. European review for medical and pharmacological sciences (Online), 24(20), 10902-10912. https://doi.org/10.26355/eurrev_202010_23455

The world will never be same after the current COVID-19 pandemic. We may have to live with the coronavirus for a long time. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has resulted in a major burden on the global health... Read More about Living with Coronavirus (COVID-19) : a brief report.

Investigating the relationship between lung cancer and the infection with the parasite Toxoplasma gondii (2020)
Thesis
Tarabulsi, M. Investigating the relationship between lung cancer and the infection with the parasite Toxoplasma gondii. (Thesis). University of Salford

Toxoplasma gondii is an obligate intracellular organism that has a worldwide distribution and is highly prevalent among animals and humans. Although usually asymptomatic, it can cause serious diseases in immunocompromised individuals such as pneumoni... Read More about Investigating the relationship between lung cancer and the infection with the parasite Toxoplasma gondii.

T‐cell responses and therapies against SARS‐CoV‐2 infection (2020)
Journal Article
Toor, S., Saleh, R., Sasidharan Nair, V., Taha, R., & Elkord, E. (2021). T‐cell responses and therapies against SARS‐CoV‐2 infection. Immunology, 162(1), 30-43. https://doi.org/10.1111/imm.13262

Coronavirus disease 2019 (COVID‐19) is caused by SARS‐CoV‐2, a novel coronavirus strain. Some studies suggest that COVID‐19 could be an immune‐related disease, and failure of effective immune responses in initial stages of viral infection could contr... Read More about T‐cell responses and therapies against SARS‐CoV‐2 infection.

In vitro screening of Trametes versicolor and Acacia nilotica derivatives for antimalarial efficacy (2020)
Thesis
Dillon, M. In vitro screening of Trametes versicolor and Acacia nilotica derivatives for antimalarial efficacy. (Dissertation). University of Salford

Of the plethora of parasitic diseases that afflict mankind, malaria remains the most prevalent. The disease has caused severe global health problems, putting 3.2 billion people at risk of developing the Plasmodium infection. With current front-line t... Read More about In vitro screening of Trametes versicolor and Acacia nilotica derivatives for antimalarial efficacy.

Novel organization of mitochondrial minicircles and guide RNAs in the zoonotic pathogen Trypanosoma lewisi (2020)
Journal Article
Li, S., Zhang, X., Lukeš, J., Li, B., Wang, J., Qu, L., …Lun, Z. (2020). Novel organization of mitochondrial minicircles and guide RNAs in the zoonotic pathogen Trypanosoma lewisi. Nucleic Acids Research, 48(17), 9747-9761. https://doi.org/10.1093/nar/gkaa700

Abstract Kinetoplastid flagellates are known for several unusual features, one of which is their complex mitochondrial genome, known as kinetoplast (k) DNA, composed of mutually catenated maxi- and minicircles. Trypanosoma lewisi is a member of the S... Read More about Novel organization of mitochondrial minicircles and guide RNAs in the zoonotic pathogen Trypanosoma lewisi.

Cancer research, treatment, and COVID-19 (2020)
Journal Article
Curley, S., Currell, F., Kirshnan, S., & Krpetic, Z. (2020). Cancer research, treatment, and COVID-19. Cancer Nanotechnology, 11, 7. https://doi.org/10.1101/2020.05.27.20115303

This is an editorial article.

SARS-CoV-2 infection and lung cancer : potential therapeutic modalities (2020)
Journal Article
Gupta, I., Rizeq, B., Elkord, E., Vranic, S., & Al Moustafa, A. (2020). SARS-CoV-2 infection and lung cancer : potential therapeutic modalities. Cancers, 12(8), e2186. https://doi.org/10.3390/cancers12082186

Human coronaviruses, especially SARS-CoV-2, are emerging pandemic infectious diseases with high morbidity and mortality in certain group of patients. In general, SARS-CoV-2 causes symptoms ranging from the common cold to severe conditions accompanied... Read More about SARS-CoV-2 infection and lung cancer : potential therapeutic modalities.

A 2-step synthesis of Combretastatin A-4 and derivatives as potent tubulin assembly inhibitors (2020)
Journal Article
Barnes, N., Parker, A., Mal Ullah, A., Ragazzon, P., & Hadfield, J. (2020). A 2-step synthesis of Combretastatin A-4 and derivatives as potent tubulin assembly inhibitors. Bioorganic and Medicinal Chemistry, 28(19), 115684. https://doi.org/10.1016/j.bmc.2020.115684

A series of combretastatin derivatives were designed and synthesised by a two-step stereoselective synthesis by use of Wittig olefination followed by Suzuki cross-coupling. Interestingly, all new compounds (2a-2i) showed potent cell-based antiprolife... Read More about A 2-step synthesis of Combretastatin A-4 and derivatives as potent tubulin assembly inhibitors.

Omega 3 versus Omega 6 polyunsaturated fatty acids in cardio-metabolic health (2020)
Journal Article
Halim, M., & Halim, A. (2020). Omega 3 versus Omega 6 polyunsaturated fatty acids in cardio-metabolic health. https://doi.org/10.36502/2020/hcr.6166

Background: Cardiometabolic diseases like type 2 diabetes, metabolic syndrome, heart failure, and other cardiovascular complications are the leading cause of mortality and morbidity across the globe. These conditions are directly attributed to modifi... Read More about Omega 3 versus Omega 6 polyunsaturated fatty acids in cardio-metabolic health.