Outputs (13)

MafB/c-Maf deficiency enables self-renewal of differentiated functional macrophages (2009)
Journal Article
Aziz, A., Soucie, E., Sarrazin, S., & Sieweke, M. (2009). MafB/c-Maf deficiency enables self-renewal of differentiated functional macrophages. Science, 326(5954), 867-871. https://doi.org/10.1126/science.1176056

In metazoan organisms, terminal differentiation is generally tightly linked to cell cycle exit, whereas the undifferentiated state of pluripotent stem cells is associated with unlimited self-renewal. Here, we report that combined deficiency for the t... Read More about MafB/c-Maf deficiency enables self-renewal of differentiated functional macrophages.

MafB restricts M-CSF-Dependent myeloid commitment divisions of hematopoietic stem cells (2009)
Journal Article

While hematopoietic stem cell (HSC) self-renewal is well studied, it remains unknown whether distinct control mechanisms enable HSC divisions that generate progeny cells with specific lineage bias. Here, we report that the monocytic transcription fac... Read More about MafB restricts M-CSF-Dependent myeloid commitment divisions of hematopoietic stem cells.

New molecular and cellular aspects of mutant calreticulin in Myeloproliferative Neoplasms
Thesis
Morlan-mairal, M. (in press). New molecular and cellular aspects of mutant calreticulin in Myeloproliferative Neoplasms. (Thesis). University of Salford

Calreticulin (CALR) is an endoplasmic reticulum (ER) protein that plays an important role as a calcium (Ca2+) buffering chaperone. Mutations in CALR exon 9 have been identified in essential thrombocythemia and primary myelofibrosis, two myeloprolifer... Read More about New molecular and cellular aspects of mutant calreticulin in Myeloproliferative Neoplasms.