Outputs (22)

Inhibition of lipopolysaccharide-stimulated chronic obstructive pulmonary disease macrophage inflammatory gene expression by dexamethasone and the p38 mitogen-activated protein kinase inhibitor N-cyano-N'-(2-{[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7-oxo-7,8-dihydropyrido[2,3-d] pyrimidin-2-yl]amino}ethyl)guanidine (SB706504) (2009)
Journal Article
Kent, L., Smyth, L., Plumb, J., Clayton, C., Fox, S., Ray, D., …Singh, D. (2009). Inhibition of lipopolysaccharide-stimulated chronic obstructive pulmonary disease macrophage inflammatory gene expression by dexamethasone and the p38 mitogen-activated protein kinase inhibitor N-cyano-N'-(2-{[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7-oxo-7,8-dihydropyrido[2,3-d] pyrimidin-2-yl]amino}ethyl)guanidine (SB706504). Journal of Pharmacology and Experimental Therapeutics, 328(2), 458-468. https://doi.org/10.1124/jpet.108.142950

p38 mitogen-activated protein kinase (MAPK) signaling is known to be increased in chronic obstructive pulmonary disease (COPD) macrophages. We have studied the effects of the p38 MAPK inhibitor N-cyano-N'-(2-{[8-(2,6-difluorophenyl)-4-(4-fluoro-2-met... Read More about Inhibition of lipopolysaccharide-stimulated chronic obstructive pulmonary disease macrophage inflammatory gene expression by dexamethasone and the p38 mitogen-activated protein kinase inhibitor N-cyano-N'-(2-{[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7-oxo-7,8-dihydropyrido[2,3-d] pyrimidin-2-yl]amino}ethyl)guanidine (SB706504).

Increased T-regulatory cells within lymphocyte follicles in moderate COPD (2009)
Journal Article
Plumb, J., Smyth, L., Adams, H., Vestbo, J., Bentley, A., & Singh, S. (2009). Increased T-regulatory cells within lymphocyte follicles in moderate COPD. European Respiratory Journal, 34(1), 89-94. https://doi.org/10.1183/%E2%80%8B09031936.00100708

Lymphoid follicles in the lung parenchyma are a characteristic feature of chronic obstructive pulmonary disease (COPD). There are reports of altered CD4 T-regulatory cell numbers in COPD lungs, but the location of these cells within COPD lung tissue... Read More about Increased T-regulatory cells within lymphocyte follicles in moderate COPD.

CD8 chemokine receptors in chronic obstructive pulmonary disease (2008)
Journal Article
Smyth, L., Starkey, C., Gordon, F., Vestbo, J., & Singh, D. (2008). CD8 chemokine receptors in chronic obstructive pulmonary disease. https://doi.org/10.1111/j.1365-2249.2008.03729.x

Increased lung CD8 cells and their expression of chemokine receptors CXCR3 and CCR5 have been previously reported in chronic obstructive pulmonary disease (COPD). Alterations of CD8-CCR3 and -CCR4 expression and their ligands in COPD patients have no... Read More about CD8 chemokine receptors in chronic obstructive pulmonary disease.

Cigarette smoke extract induced cytokine and chemokine gene expression changes in COPD macrophages (2008)
Journal Article
Kent, L., Smyth, L., Clayton, C., Scott, L., Cook, T., Stephens, R., …Singh, D. (2008). Cigarette smoke extract induced cytokine and chemokine gene expression changes in COPD macrophages. Cytokine, 42(2), 205-216. https://doi.org/10.1016/j.cyto.2008.02.001

Macrophages are key inflammatory cells in chronic obstructive pulmonary disease (COPD). The transcriptional regulation of inflammatory signalling pathways by cigarette smoke (CS) in COPD macrophages is not well understood. We have studied the effects... Read More about Cigarette smoke extract induced cytokine and chemokine gene expression changes in COPD macrophages.

Role of the mucosal integrin αE(CD103)β7 in tissue-restricted cytotoxicity (2007)
Journal Article
Smyth, L., Kirby, J., & Cunningham, A. (2007). Role of the mucosal integrin αE(CD103)β7 in tissue-restricted cytotoxicity. https://doi.org/10.1111/j.1365-2249.2007.03385.x

The effectiveness of lung transplantation is marred by the relatively high incidence of rejection. The lung normally contains a large population of lymphocytes in contact with the airway epithelium, a proportion of which expresses the mucosal integri... Read More about Role of the mucosal integrin αE(CD103)β7 in tissue-restricted cytotoxicity.

CD4-regulatory cells in COPD patients (2007)
Journal Article
Smyth, L., Starkey, C., Vestbo, J., & Singh, D. (2007). CD4-regulatory cells in COPD patients. Chest, 132(1), 156-163. https://doi.org/10.1378/chest.07-0083

Background: The numbers of airway CD8 and B lymphocytes are increased in COPD patients, suggesting an autoimmune process. CD4-regulatory T cells control autoimmunity but have not been studied in patients with COPD. Objective: To compare T-regulato... Read More about CD4-regulatory cells in COPD patients.

Cd8 T-cell recognition of human 5T4 oncofetal antigen (2006)
Journal Article
Smyth, L., Elkord, E., Taher, T., Jiang, H., Burt, D., Clayton, A., …Stern, P. (2006). Cd8 T-cell recognition of human 5T4 oncofetal antigen. International Journal of Cancer, 119(7), 1638-1647. https://doi.org/10.1002/ijc.22018

The 5T4 oncofetal antigen is expressed by a wide variety of human carcinomas, including colorectal, ovarian and gastric carcinomas. The restricted expression of 5T4 on tumor tissues as well as its implication in tumor progression and bad prognosis ma... Read More about Cd8 T-cell recognition of human 5T4 oncofetal antigen.

Effect of TA-CIN (HPV 16 L2E6E7) booster immunisation in vulval intraepithelial neoplasia patients previously vaccinated with TA-HPV (vaccinia virus encoding HPV 16/18 E6E7) (2004)
Journal Article
Davidson, E., Faulkner, R., Sehr, P., Pawlita, M., Smyth, L., Burt, D., …Stern, P. (2004). Effect of TA-CIN (HPV 16 L2E6E7) booster immunisation in vulval intraepithelial neoplasia patients previously vaccinated with TA-HPV (vaccinia virus encoding HPV 16/18 E6E7). Vaccine, 22(21-22), 2722-2729. https://doi.org/10.1016/j.vaccine.2004.01.049

Heterologous prime-boost vaccination schedules employing TA-HPV, a vaccinia virus encoding HPV 16/18 E6 and E7, in combination with TA-CIN, an HPV 16 L2E6E7 fusion protein, may offer advantages over the use of either agent alone for the immunotherapy... Read More about Effect of TA-CIN (HPV 16 L2E6E7) booster immunisation in vulval intraepithelial neoplasia patients previously vaccinated with TA-HPV (vaccinia virus encoding HPV 16/18 E6E7).

Immunological responses in women with human Papillomavirus Type 16 (HPV-16)-associated anogenital intraepithelial neoplasia induced by heterologous prime-boost HPV-16 oncogene vaccination (2004)
Journal Article
Smyth, L., Van Poelgeest, M., Davidson, E., Kwappenberg, K., Burt, D., Sehr, P., …Van Der Burg, S. (2004). Immunological responses in women with human Papillomavirus Type 16 (HPV-16)-associated anogenital intraepithelial neoplasia induced by heterologous prime-boost HPV-16 oncogene vaccination. Clinical Cancer Research, 10(9), 2954. https://doi.org/10.1158/1078-0432.CCR-03-0703

Purpose: The purpose is to study the immunogenicity of heterologous prime-boost human papillomavirus (HPV) oncogene vaccination in patients with anogenital intraepithelial neoplasia (AGIN). Experimental Design: Twenty-nine women with high-grade AG... Read More about Immunological responses in women with human Papillomavirus Type 16 (HPV-16)-associated anogenital intraepithelial neoplasia induced by heterologous prime-boost HPV-16 oncogene vaccination.

Assessment of the molecular basis of the proallergenic effects of cigarette smoke (2000)
Journal Article
Smyth, L., Machado, D., Upton, A., Good, S., Aufderheide, M., & Helm, B. (2000). Assessment of the molecular basis of the proallergenic effects of cigarette smoke. Environmental Science and Technology, 34(7), 1370-1374. https://doi.org/10.1021/es9909576

Epidemiological studies indicate a link between smoking and increased risk of immunoglobulin E-mediated allergies and asthma. The molecular basis underlying cigarette smoke related respiratory disorders are ill defined, but it is known that mast cell... Read More about Assessment of the molecular basis of the proallergenic effects of cigarette smoke.